Aberration Dmel\Df(3L)66C-G28

General Information
Symbol	Dmel\Df(3L)66C-G28	Species	D. melanogaster
Name		FlyBase ID	FBab0022326
Feature type	chromosomal_deletion

Computed Breakpoints include	66B8-66B9;66C9-66C10
Deleted segment	66B8--66C10
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Aberration
Cytological Order
Progenitor	P{white-un2}30 (Harris et al., 2003)
Mutagen	Delta2-3 (Harris et al., 2003)
Class of aberration (relative to progenitor)	chromosomal_deletion (Coyne, 1996, Deak et al., 1997, Harris et al., 2003)
Breakpoints	66B8-66B9;66C9-66C10 (Coyne, 1996, Deak et al., 1997)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	bk1 << E(dpp)66C << bk2 << RpL14
Genetic mapping information
Comments
Comments on Cytology
	All limits from polytene analysis (FBrf0086978)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	Arp3 (Rajan et al., 2009) carbuncle (Ghabrial et al., 2011) E(dpp)66C (Nicholls and Gelbart, 1998) ivy (Ghabrial et al., 2011) l(3)S002309 (Szeged Stock Center, 1998-) l(3)S103012b (Szeged Stock Center, 1998-) MED24 (Wang et al., 2008) msk (Baker et al., 2002) Nmt (Spradling et al., 1999, Ntwasa et al., 2001, BDGP Project Members, 1994-1999)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	eIF4E-3 (Spradling et al., 1999, BDGP Project Members, 1994-1999) fang (Myat et al., 2005) gim (Myat et al., 2005) gloin (Myat et al., 2005) l(3)L4111 (Spradling et al., 1999, BDGP Project Members, 1994-1999) l(3)psg2 (Wang et al., 2008) rhea (Levi et al., 2006) RpL14 (Saeboe-Larssen et al., 1997)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	Fails to complement Df(3L)ZP1. (Maroy, 1997.10.17) Df(3L)66C-G28/Df(3L)pbl-X1 lethal (Jeanette Natzle)
NOT in combination with other aberrations	Df(3L)66C-G28 embryos show defects in tracheal cell migration. (Myat et al., 2005) The Df(3L)66C-G28 chromosome acts as a dominant moderate suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion). (Mason et al., 2004) Little if any macrophage migration occurs in homozygous embryos, with most macrophages remaining in the anterior region, clustered around the foregut, at stage 13-15. (Paladi and Tepass, 2004) Heterozygosity for Df(3L)66C-G28 results in a high but variable degree of X chromosome nondisjunction (23.3% and 25.8% in two separate experiments) and fourth chromosome nondisjunction (12.7% and 25.0% in two separate experiments) in In(1)FM7/X ; sv^spa-pol females. Recombination frequency along the length of the third chromosome does not show significant deviation from normal in females carrying a multiply marked third chromosome and Df(3L)66C-G28. (Harris et al., 2003) Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome. (Coyne et al., 1998) No second site non-complementing phenotype with zip^Ebr and zip^mhc-c6.1. (Halsell and Kiehart, 1998) Shows maternal enhancement of dpp^hr4, dpp^hr56 and dpp^hr27, measured as reduction in recovery of doubly heterozygous progeny. (Nicholls and Gelbart, 1998) Midgut development of mutant embryos is wild type. (Bilder and Scott, 1995)
Stocks ( 2 )
Bloomington	1541 y¹ w¹ N^spl-1; Df(3L)66C-G28/TM3, Sb¹
Kyoto	106713 y¹ w¹ N^spl-1; Df(3L)66C-G28/TM3, Sb¹
Notes on Origin
Discoverer	J. Natzle.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	Used in D.melanogaster/D.simulans hybrids to map at least four non-overlapping regions on the D.simulans 3R that have effects on the species difference of cuticular hydrocarbon profile. (Coyne, 1996)
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	Df(3L)66C^G28 (Brumby et al., 2004) Df(3L)66C-G28 (McCaffrey et al., 2006, Levi et al., 2006, Levi et al., 2006, Crest et al., 2007, Berry and Baehrecke, 2007, Rajan et al., 2009, Rao et al., 2007, Paladi and Tepass, 2004, Wang et al., 2008, Slack et al., 2006, Ghabrial et al., 2011)
Name Synonym
Secondary FlyBase IDs

References ( 44 )

Generate a list of	All references relating to this aberration ( 44 )

List References by type	Research paper ( 38 ) Erratum ( 1 ) Personal communication to FlyBase ( 2 ) Abstract ( 1 ) FlyBase analysis ( 1 ) Stock list ( 1 )
Recent research papers ( 1 )
	Ghabrial et al., 2011, PLoS Genet. 7(7): e1002087 A systematic screen for tube morphogenesis and branching genes in the Drosophila tracheal system. [FBrf0214368] Show all research papers ...