Aberration Dmel\Df(3L)66C-G28

General Information
Symbol	Dmel\Df(3L)66C-G28	Species	D. melanogaster
Name		FlyBase ID	FBab0022326
Feature type	chromosomal_deletion	Created / Updated	2006-08-22/2006-08-22

Formalized genetic data	bk1 << E(dpp)66C << bk2 << RpL14
Sequence coordinates
Deleted segment	66B8--66C10
Duplicated segment
Computed Breakpoints include	66B8-66B9;66C9-66C10
Breakpoints Inherited
Nature of the Aberration
Cytological Order
Progenitor	P{white-un2}30 (Harris et al., 2003)
Mutagen	Δ2-3 (Harris et al., 2003)
Class of aberration (relative to progenitor)	chromosomal_deletion (Coyne, 1996, Deak et al., 1997, Harris et al., 2003)
Breakpoints	66B8-66B9;66C9-66C10 (Coyne, 1996, Deak et al., 1997)
Causes alleles
Carries alleles
Transposon Insertions
Genetic mapping information
Comments
Comments on Cytology
	All limits from polytene analysis (FBrf0086978)
Molecularly Mapped Breakpoints

Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	msk (Baker et al., 2002) Nmt (BDGP Project Members, 1994-1999, Spradling et al., 1999, Ntwasa et al., 2001) l(3)S103012b (Szeged Stock Center, 1998-) l(3)S002309 (Szeged Stock Center, 1998-) E(dpp)66C (Nicholls and Gelbart, 1998)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	rhea (Levi et al., 2006) RpL14 (Saeboe-Larssen et al., 1997) l(3)L0139 (BDGP Project Members, 1994-1999, Spradling et al., 1999) l(3)L4111 (BDGP Project Members, 1994-1999, Spradling et al., 1999) gim (Myat et al., 2005) fang (Myat et al., 2005) gloin (Myat et al., 2005)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Df(3L)66C-G28 embryos show defects in tracheal cell migration. (Myat et al., 2005) Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome. (Coyne et al., 1998) Heterozygosity for Df(3L)66C-G28 results in a high but variable degree of X chromosome nondisjunction (23.3% and 25.8% in two separate experiments) and fourth chromosome nondisjunction (12.7% and 25.0% in two separate experiments) in In(1)FM7/X ; sv^spa-pol females. Recombination frequency along the length of the third chromosome does not show significant deviation from normal in females carrying a multiply marked third chromosome and Df(3L)66C-G28. (Harris et al., 2003) Midgut development of mutant embryos is wild type. (Bilder and Scott, 1995) No second site non-complementing phenotype with zip^Ebr and zip^mhc-c6.1. (Halsell and Kiehart, 1998) Shows maternal enhancement of dpp^hr4, dpp^hr56 and dpp^hr27, measured as reduction in recovery of doubly heterozygous progeny. (Nicholls and Gelbart, 1998) The Df(3L)66C-G28 chromosome acts as a dominant moderate suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3\'WP-2,w^var}2Lt insertion). (Mason et al., 2004)
Position Effect Variegation Data

Stocks ( 2 )
Bloomington	1541 y¹ w¹ N^spl-1; Df(3L)66C-G28/TM3, Sb¹
Kyoto	106713 y¹ w¹ N^spl-1; Df(3L)66C-G28/TM3, Sb¹
Notes on Origin
Discoverer	J. Natzle.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	Used in D.melanogaster/D.simulans hybrids to map at least four non-overlapping regions on the D.simulans 3R that have effects on the species difference of cuticular hydrocarbon profile. (Coyne, 1996)
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	Df(3L)66C^G28 (Brumby et al., 2004) Df(3L)66C-G28 (McCaffrey et al., 2006, Levi et al., 2006, Levi et al., 2006, Crest et al., 2007, Berry and Baehrecke, 2007)
Name Synonym
Secondary FlyBase IDs

References ( 38 )

Generate a list of	All references relating to this aberration ( 38 )

List References by type	Research paper ( 32 ) Erratum ( 1 ) Personal communication to FlyBase ( 1 ) Abstract ( 1 ) FlyBase analysis ( 1 ) Computer file ( 2 )
Recent research papers ( 4 )
	Berry and Baehrecke, 2007, Cell 131(6): 1137--1148 Growth arrest and autophagy are required for salivary gland cell degradation in Drosophila. [FBrf0200408] Crest et al., 2007, Genetics 175(2): 567--584 Onset of the DNA replication checkpoint in the early Drosophila embryo. [FBrf0194644] Levi et al., 2006, Development 133(12): 2383--2393 Drosophila talin and integrin genes are required for maintenance of tracheal terminal branches and luminal organization. [FBrf0193035] McCaffrey et al., 2006, Genetics 174(3): 1273--1285 Drosophila mus301/spindle-C encodes a helicase with an essential role in double-strand DNA break repair and meiotic progression. [FBrf0192058] Show all research papers ...