Aberration Dmel\Df(3L)Ar12-1

General Information
Symbol	Dmel\Df(3L)Ar12-1	Species	D. melanogaster
Name		FlyBase ID	FBab0022343
Feature type	chromosomal_deletion

Computed Breakpoints include	61C1-61C4;61F3
Deleted segment	61C1--61F3
Sequence coordinates
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	References Ball et al., 2010, Neuron 66(4): 536--549
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Aberration
Cytological Order
Progenitor
Mutagen
Class of aberration (relative to progenitor)	chromosomal_deletion (Ellis, 1995.5.7, Isaac and Andrew, 1996, Pauli et al., 1995, Wilson et al., 1997)
Breakpoints	61C1-61C4;61E (Wilson et al., 1997) 61C;61F (Ellis, 1995.5.7) 61C;61F3 (Pauli et al., 1995, Isaac and Andrew, 1996)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	trh << bk1 << bk2 << Klp61F
Genetic mapping information
Comments
Comments on Cytology
	Limits of break 1 from polytene analysis (FBrf0093250) Limits of break 2 from polytene analysis (FBrf0080317)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	bab1 (Llopart et al., 2002) trio (Bateman et al., 2000, Newsome et al., 2000)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	Klp61F (Wilson et al., 1997) trh (Isaac and Andrew, 1996)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Dominantly suppresses the Kr^If-1/+ eye phenotype. (Carrera et al., 1998) Heterozygosity for this deletion enhances the mutant ovarian phenotype of ovo^D2. (Pauli et al., 1995)
Stocks ( 3 )
Bloomington	1478 Df(3L)Ar12-1, red¹/TM2, p^p
Kyoto	106335 Df(3L)Ar12-1, red¹/TM2, p^p 101589 Df(3L)Ar12-1, red¹ / TM2, emc² p^p Ubx¹³⁰ e^s
Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	The Df(3L)Ar12-1 chromosome may act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion), but the eye colour phenotype in the presence of Df(3L)Ar12-1 overlaps the eye colour phenotype in a wild-type background so it cannot be unequivocally demonstrated that the deficiency chromosome uncovers a suppressor of telomeric silencing. (Mason et al., 2004)
Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	AR12-1 (Yamaguchi et al., 2001) Df(3L)AR12-1 (Isaac and Andrew, 1996) Df(3L)Ar12-1 (Ball et al., 2010) Df(3L)emc18 Df(3L)H18 (Isaac and Andrew, 1996)
Name Synonym
Secondary FlyBase IDs
	FBab0024870
References ( 15 )
Research paper	Ball et al., 2010, Neuron 66(4): 536--549 Retrograde BMP Signaling Controls Synaptic Growth at the NMJ by Regulating Trio Expression in Motor Neurons. [FBrf0210920] Mason et al., 2004, Genetics 168(3): 1353--1370 A deficiency screen for dominant suppressors of telomeric silencing in Drosophila. [FBrf0180277] Ashton et al., 2001, Genetics 157(1): 283--294 Quantitative trait loci for the monoamine-related traits heart rate and headless behavior in Drosophila melanogaster. [FBrf0132335] Yamaguchi et al., 2001, Chromosoma 110(5): 313--321 Ectopic expression of BEAF32A in the Drosophila eye imaginal disc inhibits differentiation of photoreceptor cells and induces apoptosis. [FBrf0139613] Bateman et al., 2000, Neuron 26(1): 93--106 The guanine nucleotide exchange factor trio mediates axonal development in the Drosophila embryo. [FBrf0127003] Kopp et al., 2000, Nature 408(6812): 553--559 Genetic control and evolution of sexually dimorphic characters in Drosophila. [FBrf0132416] Newsome et al., 2000, Cell 101(3): 283--294 Trio combines with Dock to regulate Pak activity during photoreceptor axon pathfinding in Drosophila. [FBrf0128589] Carrera et al., 1998, Proc. Natl. Acad. Sci. USA 95(18): 10779--10784 A modifier screen in the eye reveals control genes for Kruppel activity in the Drosophila embryo. [FBrf0104417] Wilson et al., 1997, J. Cell Sci. 110(4): 451--464 Monastral bipolar spindles: implications for dynamic centrosome organization. [FBrf0093250] Isaac and Andrew, 1996, Genes Dev. 10(1): 103--117 Tubulogenesis in Drosophila: A requirement for the trachealess gene product. [FBrf0085269] Pauli et al., 1995, Genetics 139(2): 713--732 Identification of regions interacting with ovo^D mutations: Potential new genes involved in germline sex determination or differentiation in Drosophila melanogaster. [FBrf0080317] Pauli et al., 1995, D. I. S. 76: 107--124 Dose dependent enhancers and suppressors of ovoD2. [FBrf0082455]
Personal communication to FlyBase	Ellis, 1995.5.7, Query about some emc aberrations. Query about some emc aberrations. [FBrf0079813]
FlyBase analysis	FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]
Letter	Llopart et al., 2002, Nature 419(6905): 360 Pigmentation and mate choice in Drosophila. [FBrf0151709]