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General Information
Symbol
Df(3L)X25
Species
D. melanogaster
Name
FlyBase ID
FBab0022374
Feature type
Computed Breakpoints include
Sequence coordinates
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
Mutagen
Class of aberration (relative to wild type)
Class of aberration (relative to progenitor)
Breakpoints
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data
Genetic mapping information
Comments
Comments on Cytology
Sequence Crossreferences
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Partially deleted / disrupted
Molecular Data
Completely deleted
Partially deleted
Genes NOT Deleted / Disrupted
Complementation Data
Molecular Data
 
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Phenotypic Data
In combination with other aberrations

Df(3L)MM3/Df(3L)X25 animals have a defect in the programmed cell death of vCrz neurons: 10.8 +/- 1.9 neurons are present at 7 hours after puparium formation (APF) (these neurons are no longer present in wild-type animals at this stage) and 1.7 +/- 1.5 neurons are present at 16 hours APF.

Df(3L)XR38/Df(3L)X25 animals have a defect in the programmed cell death of vCrz neurons: 15.2 +/- 1.0 neurons are present at 7 hours after puparium formation (APF) (these neurons are no longer present in wild-type animals at this stage) and 10.7 +/- 1.2 neurons are present at 16 hours APF.

Df(3L)grim-A6C/Df(3L)X25 animals have a defect in the programmed cell death of vCrz neurons: 16 +/- 0 neurons are present at 7 hours after puparium formation (APF) (these neurons are no longer present in wild-type animals at this stage) and 7.3 +/- 1.2 neurons are present at 16 hours APF. 9.8 +/- 1.4 surviving EW3-sib cells are seen in these animals (these cells die during embryogenesis in wild type).

The normal programmed cell death of vCrz neurons is completely blocked in Df(3L)MM2/Df(3L)X25 animals (assayed at 7 hours and 16 hours after puparium formation). 10 +/- 1.3 surviving EW3-sib cells are seen in these animals (these cells die during embryogenesis in wild type).

Inferred to overlap with: Df(3L)XR38.

Larvae of the genotype Df(3L)XR38/Df(3L)X25 do not contain ectopic abdominal postembryonic neuroblasts.

66% of anterior dMP2 neurons survive in late stage Df(3L)H99/Df(3L)X25 embryos (in contrast to wild-type embryos, where these neurons are lost by the late embryonic stage). Anterior MP1 neurons survive in late stage Df(3L)H99/Df(3L)X25 embryos (in contrast to wild-type embryos, where these neurons are lost by the late embryonic stage). Few anterior dMP2 and MP1 neurons survive in Df(3L)X25/Df(3L)X14 late stage embryos (similar to wild-type embryos, where these neurons are lost by the late embryonic stage).

NOT in combination with other aberrations

The wing discs of Df(3L)X25/+ mutant third instar larvae exhibit reduced levels of apoptosis in response to X-ray induced irradiation with 4000 rads compared to controls.

The level of photoreceptor apoptosis at the periphery of developing eyes at 42 hours after puparium formation is reduced, but not eliminated, in Df(3L)X25 homozygous clones.

Anterior dMP2 neurons do not survive in heterozygous late embryos (as occurs in wild-type embryos, where these neurons are lost by the late embryonic stage). Anterior dMP2 neurons do not survive in homozygous Df(3L)X25 late embryos (as occurs in wild-type embryos, where these neurons are lost by the late embryonic stage). Most anterior MP1 neurons survive in late stage Df(3L)X25 embryos (in contrast to wild-type embryos, where these neurons are lost by the late embryonic stage).

The death of the ventral crustacean cardioactive peptide immunoreactive (vCCAP-IR) neurons of the ventral nervous system is delayed by approximately 12 hours in heterozygous flies.

Some apoptotic cell death occurs in homozygous embryos, and a variable fraction of hemocytes contain cellular debris. The cephalopharyngeal skeleton is largely normal, although the Lateralgraten are shorter and closer to the surface than normal.

Apoptosis is essentially normal in homozygotes but reduced in Df(3L)X25/Df(3L)H99 embryos.

Stocks (0)
Notes on Origin
Discoverer
 
Balancer / Genotype Variants of the Aberration
 
Separable Components
 
Other Comments
 
Synonyms and Secondary IDs (5)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (16)