FB2025_01 , released February 20, 2025
Aberration: Dmel\Df(3R)3450
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General Information
Symbol
Df(3R)3450
Species
D. melanogaster
Name
FlyBase ID
FBab0022382
Feature type
chromosomal_deletion
Also Known As
Df3450
Computed Breakpoints include

98E3;99A6

Features within 98E3--99A6
Sequence coordinates
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
Mutagen
gamma ray
Class of aberration (relative to wild type)
chromosomal_deletion
(FlyBase, 2007)
Class of aberration (relative to progenitor)
chromosomal_deletion
(Ahmed et al., 1998, Salzberg et al., 1997)
Breakpoints

98E3;99A4-99A6

(Hayashi et al., 1997)

98E3;99A6-99A8

(Salzberg et al., 1997)

98E3;99A6

(Ahmed et al., 1998)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data

bk1 << spg << bk2 << l(3)02521

Genetic mapping information
Comments
Comments on Cytology

Limits of break 1 from polytene analysis (FBrf0091073) Left limit of break 2 from polytene analysis (FBrf0099763) Right limit of break 2 from polytene analysis (FBrf0091073)

Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
Apc
(Hayashi et al., 1997)
bek
(Kankel et al., 2004)
Cnx99A
(Rosenbaum et al., 2006)
Cul5
(Ayyub et al., 2005)
Doa
(Morris et al., 2003, Yun et al., 2000, Spradling et al., 1999, Szeged Stock Center, 1998-, Hayashi et al., 1997, BDGP Project Members, 1994-1999)
l(3)3450-A
(Ahmed, 2002.7.16)
l(3)3450-B
(Ahmed, 2002.7.16)
l(3)3450-C
(Ahmed, 2002.7.16)
l(3)3450-D
(Ahmed, 2002.7.16)
l(3)3450-E
(Ahmed, 2002.7.16)
l(3)3450-F
(Ahmed, 2002.7.16)
l(3)3450-G
(Ahmed, 2002.7.16)
l(3)3450-H
(Ahmed, 2002.7.16)
l(3)3450-I
(Ahmed, 2002.7.16)
l(3)3450-J
(Ahmed, 2002.7.16)
l(3)3450-K
(Ahmed, 2002.7.16)
l(3)3450-L
(Ahmed, 2002.7.16)
l(3)3450-M
(Ahmed, 2002.7.16)
l(3)3450-N
(Ahmed, 2002.7.16)
l(3)3450-O
(Ahmed, 2002.7.16)
l(3)3450-P
(Ahmed, 2002.7.16)
l(3)04708
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
l(3)S007902
(Szeged Stock Center, 1998-)
l(3)S044422
(Szeged Stock Center, 1998-)
l(3)S085009
(Szeged Stock Center, 1998-)
l(3)S085301
(Szeged Stock Center, 1998-)
l(3)S101310
(Szeged Stock Center, 1998-)
l(3)S147506
(Szeged Stock Center, 1998-)
mir-279
(Szeged Stock Center, 1998-)
sd-2
(Babcock et al., 2003)
Slbp
(Sullivan et al., 2001)
spg
(Hayashi et al., 1997)
stg
(Szeged Stock Center, 1998-, Hayashi et al., 1997, Verheyen et al., 1996)
stoc
(Luschnig et al., 2004)
Tsc1
(Ghabrial et al., 2011)
Vha100-1
(Hiesinger et al., 2005)
WASp
(Schafer et al., 2007, Tal et al., 2002, Ben-Yaacov et al., 2001)
Partially deleted / disrupted
Molecular Data
Completely deleted
Cul5
(Ayyub, 2011)
eEF1γ
(Marygold et al., 2007)
eIF2D
(Marygold et al., 2007)
eIF4E6
(Marygold et al., 2007)
Partially deleted
Genes NOT Deleted / Disrupted
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location (0)
    If no genes are listed here, it may be because the affected region is very large. The JBrowse insert above may show an error for the same reason, and other FlyBase tools such as CytoSearch may also fail for large regions. You can contact FlyBase for more help.
    In these cases, there will be no "Export to Hitlist" button to the left.
    Phenotypic Data
    In combination with other aberrations
    NOT in combination with other aberrations

    Df(3R)3450 mutant clones in sensory neurons in adult wing do not display any defects in injury-induced axon degeneration (following an axotomy, the severed axons are cleared away normally).

    (Neukomm et al., 2017)

    Embryos homozygous for Df(3R)3450, which uncovers Cul5, have no detectable defects in tracheal morphology.

    (Ayyub, 2011)

    Df(3R)3450/+ adults show a reduction in notal bristles.

    (Ayyub et al., 2005)

    The size of the tracheal lumen is different to wild type in Df(3R)3450 embryos.

    (Myat et al., 2005)

    The Df(3R)3450 chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{wvar}KR3-2", a stable "brown-red" variant of the P{3'WP-2,wvar}2Lt insertion).

    (Mason et al., 2004)

    Heterozygosity for Df(3R)3450 results in 0.0% X chromosome nondisjunction and 0.0% fourth chromosome nondisjunction in In(1)FM7/X ; svspa-pol females.

    (Harris et al., 2003)

    No second site non-complementing phenotype with zipEbr and zipmhc-c6.1.

    (Halsell and Kiehart, 1998)

    Shows no maternal enhancement of dpphr4.

    (Nicholls and Gelbart, 1998)

    Midgut development of mutant embryos is wild type.

    (Bilder and Scott, 1995)
    Stocks (2)
    Notes on Origin
    Discoverer

    S. Hayashi.

     
    Balancer / Genotype Variants of the Aberration
     
    Separable Components
     
    Other Comments
     
    Synonyms and Secondary IDs (9)
    References (84)