Aberration Dmel\Df(3R)3450

General Information
Symbol	Dmel\Df(3R)3450	Species	D. melanogaster
Name		FlyBase ID	FBab0022382
Feature type	chromosomal_deletion
Also Known As	Df3450

Computed Breakpoints include	98E3;99A6
Deleted segment	98E3--99A6
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Aberration
Cytological Order
Progenitor
Mutagen	gamma ray
Class of aberration (relative to progenitor)	chromosomal_deletion (Salzberg et al., 1997, Ahmed et al., 1998)
Breakpoints	98E3;99A4-99A6 (Hayashi et al., 1997) 98E3;99A6 (Ahmed et al., 1998) 98E3;99A6-99A8 (Salzberg et al., 1997)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	bk1 << spg << bk2 << l(3)02521
Genetic mapping information
Comments
Comments on Cytology
	Limits of break 1 from polytene analysis (FBrf0091073) Left limit of break 2 from polytene analysis (FBrf0099763) Right limit of break 2 from polytene analysis (FBrf0091073)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	Apc (Hayashi et al., 1997) bek (Kankel et al., 2004) Cnx99A (Rosenbaum et al., 2006) Cul-5 (Ayyub et al., 2005) Doa (Spradling et al., 1999, BDGP Project Members, 1994-1999, Szeged Stock Center, 1998-, Yun et al., 2000, Morris et al., 2003, Hayashi et al., 1997) l(3)3450-A (Ahmed, 2002.7.16) l(3)3450-B (Ahmed, 2002.7.16) l(3)3450-C (Ahmed, 2002.7.16) l(3)3450-D (Ahmed, 2002.7.16) l(3)3450-E (Ahmed, 2002.7.16) l(3)3450-F (Ahmed, 2002.7.16) l(3)3450-G (Ahmed, 2002.7.16) l(3)3450-H (Ahmed, 2002.7.16) l(3)3450-I (Ahmed, 2002.7.16) l(3)3450-J (Ahmed, 2002.7.16) l(3)3450-K (Ahmed, 2002.7.16) l(3)3450-L (Ahmed, 2002.7.16) l(3)3450-M (Ahmed, 2002.7.16) l(3)3450-N (Ahmed, 2002.7.16) l(3)3450-O (Ahmed, 2002.7.16) l(3)3450-P (Ahmed, 2002.7.16) l(3)04708 (Spradling et al., 1999, BDGP Project Members, 1994-1999) l(3)S007902 (Szeged Stock Center, 1998-) l(3)S044422 (Szeged Stock Center, 1998-) l(3)S085009 (Szeged Stock Center, 1998-) l(3)S085301 (Szeged Stock Center, 1998-) l(3)S101310 (Szeged Stock Center, 1998-) l(3)S147506 (Szeged Stock Center, 1998-) mir-279 (Szeged Stock Center, 1998-) sd-2 (Babcock et al., 2003) Slbp (Sullivan et al., 2001) spg (Hayashi et al., 1997) stg (Szeged Stock Center, 1998-, Verheyen et al., 1996, Hayashi et al., 1997) stoc (Luschnig et al., 2004) Tsc1 (Ghabrial et al., 2011) Vha100-1 (Hiesinger et al., 2005) WASp (Ben-Yaacov et al., 2001, Tal et al., 2002, Schafer et al., 2007)
Molecular Data
Completely deleted	Cul-5 (Ayyub, 2011)
Genes NOT Deleted / Disrupted
Complementation Data
	fang (Myat et al., 2005) gim (Myat et al., 2005) gloin (Myat et al., 2005) l(3)02521 (BDGP Project Members, 1994-1999) l(3)s2976 (Spradling et al., 1999, BDGP Project Members, 1994-1999) scrib (Brumby et al., 2004) stg (Spradling et al., 1999, BDGP Project Members, 1994-1999, Salzberg et al., 1997)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Embryos homozygous for Df(3R)3450, which uncovers Cul-5, have no detectable defects in tracheal morphology. (Ayyub, 2011) Df(3R)3450/+ adults show a reduction in notal bristles. (Ayyub et al., 2005) The size of the tracheal lumen is different to wild type in Df(3R)3450 embryos. (Myat et al., 2005) The Df(3R)3450 chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion). (Mason et al., 2004) Heterozygosity for Df(3R)3450 results in 0.0% X chromosome nondisjunction and 0.0% fourth chromosome nondisjunction in In(1)FM7/X ; sv^spa-pol females. (Harris et al., 2003) No second site non-complementing phenotype with zip^Ebr and zip^mhc-c6.1. (Halsell and Kiehart, 1998) Shows no maternal enhancement of dpp^hr4. (Nicholls and Gelbart, 1998) Midgut development of mutant embryos is wild type. (Bilder and Scott, 1995)
Stocks ( 2 )
Bloomington	430 w¹¹¹⁸; Df(3R)3450/TM6B, Tb¹
Kyoto	108901 w¹¹¹⁸; Df(3R)3450/TM6B, Tb¹
Notes on Origin
Discoverer	S. Hayashi.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	Df3450 (Meyer et al., 2010, Ayyub, 2011) Df(3)3450 (Galy et al., 2011) DF(3R)3450 (Harris et al., 2003) Df(3R)3450 (Hiesinger et al., 2005, Bogdan et al., 2005, Rosenbaum et al., 2006, Bejarano et al., 2008, Li et al., 2012, Fan et al., 2010, Johnson et al., 2008, Ayyub et al., 2005, Schafer et al., 2007, Nahm et al., 2010, Li et al., 2012, Khuong et al., 2010, Henthorn et al., 2011, Ayyub, 2011, Rotkopf et al., 2011, Biersmith et al., 2011, Nahm et al., 2010, Ghabrial et al., 2011, Kpebe and Rabinow, 2008) Df(3R) 3450 (Fiehler and Wolff, 2008) v100 def (Coen et al., 2012)
Name Synonym
Secondary FlyBase IDs

References ( 72 )

Generate a list of	All references relating to this aberration ( 72 )

List References by type	Research paper ( 65 ) Supplementary material ( 2 ) Personal communication to FlyBase ( 3 ) FlyBase analysis ( 1 ) Stock list ( 1 )
Recent research papers ( 8 )
	Coen et al., 2012, J. Cell Biol. 198(1): 23--35 Lysosomal calcium homeostasis defects, not proton pump defects, cause endo-lysosomal dysfunction in PSEN-deficient cells. [FBrf0218810] Li et al., 2012, Curr. Biol. 22(22): 2104--2113 Lipid droplets control the maternal histone supply of Drosophila embryos. [FBrf0220040] Ayyub, 2011, J. Genet. 90(2): 239--249 Cullin-5 and cullin-2 play a role in the development of neuromuscular junction and the female germ line of Drosophila. [FBrf0214802] Biersmith et al., 2011, PLoS ONE 6(1): e16120 The DOCK Protein Sponge Binds to ELMO and Functions in Drosophila Embryonic CNS Development. [FBrf0212890] Galy et al., 2011, Dev. Biol. 359(1): 37--46 CYFIP dependent Actin Remodeling controls specific aspects of Drosophila eye morphogenesis. [FBrf0216378] Ghabrial et al., 2011, PLoS Genet. 7(7): e1002087 A systematic screen for tube morphogenesis and branching genes in the Drosophila tracheal system. [FBrf0214368] Henthorn et al., 2011, Mol. Biol. Cell 22(21): 4038--4046 A role for kinesin heavy chain in controlling vesicle transport into dendrites in Drosophila. [FBrf0216511] Rotkopf et al., 2011, Development 138(13): 2729--2739 The WASp-based actin polymerization machinery is required in somatic support cells for spermatid maturation and release. [FBrf0213892] Show all research papers ...