Aberration Dmel\In(2R)vg^W

General Information
Symbol	Dmel\In(2R)vg^W	Species	D. melanogaster
Name		FlyBase ID	FBab0022791
Feature type	chromosomal_inversion

Computed Breakpoints include	48A2;49D1-49D6
Sequence coordinates	2R:8,772,611..8,773,456 [+] (In(2R)vg[W]:bk2) (Williams et al., 1990)
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Aberration
Cytological Order
Progenitor
Mutagen	X ray (Shukla, 1980)
Class of aberration (relative to progenitor)	chromosomal_deletion (Duffy et al., 1996) chromosomal_inversion (Rabinow et al., 1991, Williams et al., 1990, Bownes and Roberts, 1981)
Breakpoints	47F15-48A2;49E4-49E5 (Bownes and Roberts, 1981) 47F;49C (Duffy et al., 1996) 48A;49D (Williams et al., 1990, Rabinow et al., 1991)
Causes alleles	inv^W (Simmonds and Bell, 1998, Williams et al., 1990, Williams et al., 1991, Simmonds and Bell, 1995, Simmonds et al., 1995, Tabata et al., 1995, Simmonds et al., 1997) vg^W (Simmonds and Bell, 1998, Shukla, 1980, Bownes and Roberts, 1981, Williams et al., 1990, Williams et al., 1991, Simmonds et al., 1997)
Carries alleles
Transposon Insertions
Formalized genetic data	bk1 hits inv << bk2 hits vg
Genetic mapping information
Comments
Comments on Cytology
	Ref: FBrf0034416. 2kb of DNA is lost at the 48A inversion breakpoint. (Williams et al., 1990) Limits of break 1 from complementation mapping against inv (FBrf0051982) Limits of break 2 from complementation mapping against vg (FBrf0034416)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	Cct5 (Spradling et al., 1999, BDGP Project Members, 1994-1999) inv (Williams et al., 1990, Simmonds et al., 1997) vg (Williams et al., 1990, Simmonds et al., 1997)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	Ef1α48D (BDGP Project Members, 1994-1999) Egm (Spradling et al., 1999, BDGP Project Members, 1994-1999) en (Williams et al., 1990) l(2)k11404 (Spradling et al., 1999, BDGP Project Members, 1994-1999) l(2)k13403 (BDGP Project Members, 1994-1999) l(2)k17019a (BDGP Project Members, 1994-1999) Sin3A (BDGP Project Members, 1994-1999) Tapδ (BDGP Project Members, 1994-1999)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Homozygous lethal. (Simmonds and Bell, 1998) Dominantly causes tergite defects in less than 50% of run³ heterozygotes. (Duffy et al., 1996)
Stocks ( 2 )
Bloomington	1573 In(2R)vg^W, vg^W inv^W/In(2L)Cy, In(2R)Cy, amos^Roi-1 cn² bw¹ or¹ sp²
Kyoto	106394 In(2R)vg^W, vg^W inv^W/In(2L)Cy, In(2R)Cy, amos^Roi-1 cn² bw¹ or¹ sp²
Notes on Origin
Discoverer	Shukla.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	Df(2R)vg^W (Duffy et al., 1996) In(2R)inv^D In(2R)vg^W unnamed (Bownes and Roberts, 1981)
Name Synonym
Secondary FlyBase IDs
	FBab0022787 FBab0024858
References ( 18 )
Research paper	Srivastava et al., 2002, Genome 45(6): 1077--1082 The relationship between the dominant Additional vein mutant in Drosophila melanogaster and engrailed. [FBrf0155819] Spradling et al., 1999, Genetics 153(1): 135--177 The Berkeley Drosophila genome project gene disruption project. Single P-element insertions mutating 25% of vital Drosophila genes. [FBrf0111489] Simmonds and Bell, 1998, Genome 41(3): 381--390 A genetic and molecular analysis of an invected-Dominant mutation in Drosophila melanogaster. [FBrf0104514] Simmonds et al., 1997, Mech. Dev. 67(1): 17--33 The effect of dominant vestigial alleles upon vestigial-mediated wing patterning during development of Drosophila melanogaster. [FBrf0098887] Duffy et al., 1996, Genetics 142(3): 839--852 Dosage-sensitive maternal modifiers of the Drosophila segmentation gene runt. [FBrf0086390] Simmonds et al., 1995, Nature 376(6539): 424--427 Distinguishable functions for engrailed and invected in anterior-posterior patterning in the Drosophila wing. [FBrf0082604] Tabata et al., 1995, Development 121(10): 3359--3369 Creating a Drosophila wing de novo, the role of engrailed, and the compartment border hypothesis. [FBrf0084427] Rabinow et al., 1991, Genetics 129: 463--480 A trans-acting regulatory gene that inversely affects the expression of the white, brown and scarlet loci in Drosophila. [FBrf0054158] Williams et al., 1991, Genes Dev. 5: 2481--2495 Control of Drosophila wing and haltere development by the nuclear vestigial gene product. [FBrf0054054] Williams et al., 1990, Genetics 125: 833--844 Genetic and molecular analysis of vg^U and vg^W: two dominant vg alleles associated with gene fusions in Drosophila. [FBrf0051982] Williams and Bell, 1988, EMBO J. 7: 1355--1363 Molecular organization of the vestigial region in Drosophila melanogaster. [FBrf0047923] Bownes and Roberts, 1981, J. Embryol. exp. Morphol. 65(Suppl.): 49--76 Analysis of vestigial^W (vg^W) a mutation causing homoeosis of haltere to wing and posterior wing duplications in Drosophila melanogaster. [FBrf0036848] Shukla, 1980, D. I. S. 55: 210 Report of New Mutants -- Drosophila melanogaster. [FBrf0034416]
Personal communication to FlyBase	Simmonds, 1995.5.30, vg<up>WRK2</up>. vg^WRK2. [FBrf0080575] BDGP Project Members, 1994-1999, BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) [FBrf0067338]
Abstract	Simmonds and Bell, 1995, A. Dros. Res. Conf. 36: 250B Ectopic invected expression causes an anterior to posterior transformation within the adult wing of D. melanogaster. [FBrf0079405]
FlyBase analysis	FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905]

Aberration Dmel\In(2R)vgW

Aberration Dmel\In(2R)vg^W