Aberration Dmel\Ts(1Lt;2Lt)sc^S2

General Information
Symbol	Dmel\Ts(1Lt;2Lt)sc^S2	Species	D. melanogaster
Name		FlyBase ID	FBab0022972
Feature type	chromosomal_deletion

Computed Breakpoints include
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Aberration
Cytological Order
Progenitor	T(1;2)sc^S2
Mutagen	segregation
Class of aberration (relative to progenitor)
Breakpoints
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data
Genetic mapping information
Comments
Comments on Cytology

Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	Peb (Ludwig et al., 1991)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	When males with Dp(1;1)Co are crossed with T(1;2)sc^S2 females, and somatic clones are induced (in the wing disc) with a FRT site at 18A, clones with cells containing 4 copies of dm (2 endogenous and 2 from the tandem duplication in Dp(1;1)Co) and heterozygous for RpL19 (due to missing one copy of RpL19 on Ts(1Lt;2Lt)sc^S2). These clones are unable to out-compete surrounding cells and are eliminated. (Moreno and Basler, 2004)
NOT in combination with other aberrations	Ts(1Lt;2Lt)sc^S2/+ animals survive to adulthood. Ts(1Lt;2Lt)sc^S2/+ clones in a wild-type background in the wing disc are readily observed by 24 hours after clone induction, but after 24 hours the Ts(1Lt;2Lt)sc^S2/+ clones are smaller than their Ts(1Rt;2Rt)sc^S2 twin clones and their frequency decreases. At 48 hours after clone induction Ts(1Lt;2Lt)sc^S2/+ clones are not observed. There is evidence for apoptosis associated with the Ts(1Lt;2Lt)sc^S2/+ clones. (Moreno et al., 2002)
Stocks ( 0 )

Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	Df(2)M60E (Moreno et al., 2002) Df(2R)sc^S2 Ts(1Lt;2Lt)sc^S2
Name Synonym
Secondary FlyBase IDs

References ( 4 )
Research paper	Moreno and Basler, 2004, Cell 117(1): 117--129 dMyc transforms cells into super-competitors. [FBrf0174445] Moreno et al., 2002, Nature 416(6882): 755--759 Cells compete for decapentaplegic survival factor to prevent apoptosis in Drosophila wing development. [FBrf0147169] Ludwig et al., 1991, Biochem. Genet. 29: 215--239 Genetic control and expression of the major ejaculatory bulb protein (PEB-me) in Drosophila melanogaster. [FBrf0053201]
FlyBase analysis	FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]

Aberration Dmel\Ts(1Lt;2Lt)scS2

Aberration Dmel\Ts(1Lt;2Lt)sc^S2