FB2025_01 , released February 20, 2025
Aberration: Dmel\Df(2R)Np5
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General Information
Symbol
Df(2R)Np5
Species
D. melanogaster
Name
FlyBase ID
FBab0024011
Feature type
chromosomal_deletion
Also Known As
Df3591
Computed Breakpoints include

44F11;45D9-45E1

Features within 44F12--45E3 (Estimated cytology)
Genomic Maps
Sequence coordinates
2R:8,961,340..8,965,461 (Df(2R)Np5:bk1)
2R:8,962,499..8,963,330 [+] (Df(2R)Np5:bk1)
2R:9,433,164..9,524,270 (Df(2R)Np5:bk2)
(Cook et al., 2010.2.12)
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
In(2LR)w45-32n
(Konev et al., 1994)
Mutagen
Class of aberration (relative to wild type)
chromosomal_deletion
(Cook et al., 2010.2.12, FlyBase, 2007)
Class of aberration (relative to progenitor)
chromosomal_deletion
(Zhang et al., 1996, Konev et al., 1994)
Breakpoints

44F10-44F11;45D9-45E1

(Konev et al., 1994)

44F9-44F10;45D9-45E1

(Zhang et al., 1996)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data

babo << bk1 << l(2)44Fe << wun << bk2

Genetic mapping information
Comments

Breakpoint 1 was mapped to an EcoRI-XbaI restriction fragment. The position of the restriction fragment on the reference sequence was inferred by a FlyBase curator.

(Brummel et al., 1999)
Comments on Cytology

The left Df(2R)Np5 breakpoint lies within babo or CG8216 or in the region between them, and lies in the range 2R:4848845..4852966 (R5) (predicted cytology: 44F12-44F12).

(Cook et al., 2010.2.12)

The right Df(2R)Np5 breakpoint lies within Pdk or brp or in the region between them, and lies in the range 2R:5320669..5411775 (R5) (predicted cytology: 45D6-45E3).

(Cook et al., 2010.2.12)

Ref: FBrf0054224.

(Zhang et al., 1996)

Left limit of break 1 from non-inclusion of babo (FBrf0073600) Right limit of break 1 from polytene analysis (FBrf0073600) Limits of break 2 from polytene analysis (FBrf0073600)

Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
alc
(Konev et al., 1994)
Camta
(Sato et al., 2019)
cri
(Mohr and Boswell, 2002)
l(2)44Fe
(Konev et al., 1994)
l(2)45Aa
(Konev et al., 1994)
l(2)45Ab
(Mohr and Boswell, 2002, Konev et al., 1994)
l(2)45ABa
(Konev et al., 1994)
l(2)45ABb
(Konev et al., 1994)
l(2)45Ac
(Konev et al., 1994)
l(2)45Ah
(Mohr and Boswell, 2002)
l(2)45Aj
(Mohr and Boswell, 2002)
l(2)45An
(Mohr and Boswell, 2002)
l(2)45Ao
(Mohr and Boswell, 2002)
l(2)45Ap
(Mohr and Boswell, 2002)
l(2)45Aq
(Mohr and Boswell, 2002)
l(2)45Ar
(Mohr and Boswell, 2002)
l(2)45As
(Mohr and Boswell, 2002)
l(2)45Bb
(Konev et al., 1994)
l(2)45Bc
(Spradling et al., 1999, BDGP Project Members, 1994-1999, Konev et al., 1994)
l(2)45Cb
(Konev et al., 1994)
l(2)45CDa
(Kozopas, 2003.3)
l(2)03659
(Kozopas, 2003.3, Spradling et al., 1999, Zhang et al., 1996, BDGP Project Members, 1994-1999)
l(2)k10201
(BDGP Project Members, 1994-1999)
l(2)k11201
(BDGP Project Members, 1994-1999)
l(2)k13412
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
Myd88
(Kambris et al., 2003, Tauszig-Delamasure et al., 2002)
Np
(Mohr and Boswell, 2002, Konev et al., 1994)
Pkn
(Spradling et al., 1999, Zhang et al., 1996, BDGP Project Members, 1994-1999, Konev et al., 1994)
rad201
(Konev et al., 1994)
Rme-8
(Konev et al., 1994)
shrb
(Sweeney et al., 2006)
sip
(Mohr and Boswell, 2002)
srg
(Konev et al., 1994)
su(rdgA)40
(Georgiev et al., 2012)
Su(var)2-10
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
tsu
(Mohr and Boswell, 2002, Hachet and Ephrussi, 2001, Mohr et al., 2001)
wun
(Kozopas, 2003.3, Spradling et al., 1999, Zhang et al., 1996, BDGP Project Members, 1994-1999)
wun2
(Hanyu-Nakamura et al., 2004)
Partially deleted / disrupted
Molecular Data
Completely deleted
ced-6
(Georgiev et al., 2012)
CG13739
(Georgiev et al., 2012)
CG13954
(Georgiev et al., 2012)
Myd88
(Tauszig-Delamasure et al., 2002)
Non1
(Georgiev et al., 2012)
Pdk
(Georgiev et al., 2012)
wun
(Georgiev et al., 2012)
wun2
(Georgiev et al., 2012)
Partially deleted
Genes NOT Deleted / Disrupted
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location (0)
    If no genes are listed here, it may be because the affected region is very large. The JBrowse insert above may show an error for the same reason, and other FlyBase tools such as CytoSearch may also fail for large regions. You can contact FlyBase for more help.
    In these cases, there will be no "Export to Hitlist" button to the left.
    Phenotypic Data
    In combination with other aberrations
    NOT in combination with other aberrations

    Heterozygosity for Df(2R)Np5 results in 0.6% X chromosome nondisjunction and 0.2% fourth chromosome nondisjunction in In(1)FM7/X ; svspa-pol females.

    (Harris et al., 2003)
    Stocks (3)
    Notes on Origin
    Discoverer
     
    Balancer / Genotype Variants of the Aberration
     
    Separable Components
     
    Other Comments
     

    The Df(2R)Np5 chromosome may act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{wvar}KR3-2", a stable "brown-red" variant of the P{3'WP-2,wvar}2Lt insertion), but the eye colour phenotype in the presence of Df(2R)Np5 overlaps the eye colour phenotype in a wild-type background so it cannot be unequivocally demonstrated that the deficiency chromosome uncovers a suppressor of telomeric silencing. In addition, any suppression is a false positive result (the suppressor is not within the bounds of the deficient region) because the region of the deficiency is covered by one or more nonsuppressing deficiencies.

    (Mason et al., 2004)
    Synonyms and Secondary IDs (4)
    References (38)