Aberration Dmel\Df(2R)w73-1

General Information
Symbol	Dmel\Df(2R)w73-1	Species	D. melanogaster
Name		FlyBase ID	FBab0024014
Feature type	chromosomal_deletion

Computed Breakpoints include	45A9-45A10;45D5-45D8
Deleted segment	45A9--45D8
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Aberration
Cytological Order
Progenitor	In(2R)w45-73n
Mutagen
Class of aberration (relative to progenitor)	chromosomal_deletion (Konev et al., 1994, Zhang et al., 1996)
Breakpoints	45A9-45A10;45D5-45D8 (Konev et al., 1994, Zhang et al., 1996)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	l(2)45Ab << bk1 << l(2)45Ac << wun << bk2 << wun
Genetic mapping information
Comments
Comments on Cytology
	Ref: FBrf0054224. (Zhang et al., 1996) All limits from polytene analysis (FBrf0073600)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	alc (Konev et al., 1994) l(2)45ABa (Konev et al., 1994) l(2)45ABb (Konev et al., 1994) l(2)45Ac (Konev et al., 1994) l(2)45Bb (Konev et al., 1994) l(2)45Bc (BDGP Project Members, 1994-1999, Konev et al., 1994) l(2)45Cb (Konev et al., 1994) l(2)03659 (BDGP Project Members, 1994-1999, Zhang et al., 1996) l(2)k10201 (BDGP Project Members, 1994-1999) l(2)k11201 (BDGP Project Members, 1994-1999) Pkn (Lu and Settleman, 1999, BDGP Project Members, 1994-1999, Konev et al., 1994, Zhang et al., 1996) rad201 (Konev et al., 1994) Rme-8 (Konev et al., 1994) srg (Konev et al., 1994) wun (Zhang et al., 1996) wun2 (Hanyu-Nakamura et al., 2004)
Molecular Data
Completely deleted	wun (Georgiev et al., 2012)
Genes NOT Deleted / Disrupted
Complementation Data
	babo (Konev et al., 1994) dap (BDGP Project Members, 1994-1999) l(2)44Fa (Konev et al., 1994) l(2)44Fb (Konev et al., 1994) l(2)44Fc (Konev et al., 1994) l(2)44Fe (Konev et al., 1994) l(2)45Aa (Konev et al., 1994) l(2)45Ab (Konev et al., 1994) l(2)03497 (BDGP Project Members, 1994-1999) l(2)06424 (BDGP Project Members, 1994-1999) l(2)k00313 (BDGP Project Members, 1994-1999) Np (Konev et al., 1994) su(rdgA)40 (Georgiev et al., 2012) Su(var)2-10 (BDGP Project Members, 1994-1999) wun (BDGP Project Members, 1994-1999, Zhang et al., 1996)
Molecular Data
	Camta (Han et al., 2006, Georgiev et al., 2012) ced-6 (Georgiev et al., 2012) Pdk (Georgiev et al., 2012) Wnt2 (Georgiev et al., 2012) wun2 (Georgiev et al., 2012)
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	The Df(2R)w73-1 chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion). (Mason et al., 2004)
Stocks ( 2 )
Bloomington	6246 w¹; Df(2R)w73-1, cn¹/CyO
Kyoto	108701 w¹; Df(2R)w73-1, cn¹/CyO
Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	Df(2R)73-1 (Starz-Gaiano et al., 2001) Df(2R)w73-1 (Doherty et al., 2009, McPhee et al., 2010, Georgiev et al., 2012) Df(45C) (Lu and Settleman, 1999) Df(dCed-6) (Doherty et al., 2009) w73-1 (Han et al., 2006)
Name Synonym
Secondary FlyBase IDs

References ( 14 )
Research paper	Georgiev et al., 2012, J. Neurogenet. 26(3-4): 338--347 Identification of a suppressor of retinal degeneration in Drosophila photoreceptors. [FBrf0220084] McPhee et al., 2010, Nature 465(7301): 1093--1096 Activation of autophagy during cell death requires the engulfment receptor Draper. [FBrf0211145] Doherty et al., 2009, J. Neurosci. 29(15): 4768--4781 Ensheathing glia function as phagocytes in the adult Drosophila brain. [FBrf0207750] Han et al., 2006, Cell 127(4): 847--858 The fly CAMTA transcription factor potentiates deactivation of rhodopsin, a G protein-coupled light receptor. [FBrf0192912] Hanyu-Nakamura et al., 2004, Development 131(18): 4545--4553 Germ cell-autonomous Wunen2 is required for germline development in Drosophila embryos. [FBrf0180147] Mason et al., 2004, Genetics 168(3): 1353--1370 A deficiency screen for dominant suppressors of telomeric silencing in Drosophila. [FBrf0180277] Shulman and Feany, 2003, Genetics 165(3): 1233--1242 Genetic modifiers of tauopathy in Drosophila. [FBrf0167629] Starz-Gaiano et al., 2001, Development 128(6): 983--991 Spatially restricted activity of a Drosophila lipid phosphatase guides migrating germ cells. [FBrf0134584] Dockendorff et al., 2000, Mol. Gen. Genet. 263(1): 137--143 Genetic characterization of the 44D-45B region of the Drosophila melanogaster genome based on an F₂ lethal screen. [FBrf0126727] Lu and Settleman, 1999, Genes Dev. 13(9): 1168--1180 The Drosophila pkn protein kinase is a Rho/Rac effector target required for dorsal closure during embryogenesis. [FBrf0108231] Zhang et al., 1996, Genetics 143(3): 1231--1241 Identification and genetic analysis of wunen, a gene guiding Drosophila melanogaster germ cell migration. [FBrf0089219] Konev et al., 1994, Genetika, Moscow 30(2): 201--211 [Cytogenetic analysis of the chromosome region containing radiosensitivity gene in Drosophila.] [FBrf0073600]
Personal communication to FlyBase	BDGP Project Members, 1994-1999, BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) [FBrf0067338]
FlyBase analysis	FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]