Aberration Dmel\Df(3R)mbc-R1

General Information
Symbol	Dmel\Df(3R)mbc-R1	Species	D. melanogaster
Name		FlyBase ID	FBab0024033
Feature type	chromosomal_deletion

Computed Breakpoints include	95A5-95A7;95D6-95D11
Deleted segment	95A5--95D11
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Aberration
Cytological Order
Progenitor	P{lArB}A189.2F3 (Rushton et al., 1995)
Mutagen	X ray (Rushton et al., 1995)
Class of aberration (relative to progenitor)	chromosomal_deletion (Rushton et al., 1995)
Breakpoints	95A5-95A7;95D6-95D11 (Rushton et al., 1995)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	bk1 << mbc << bk2
Genetic mapping information
Comments
Comments on Cytology
	All limits from polytene analysis (FBrf0080363)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	E(rst)C463 (Tanenbaum et al., 2000) E(rst)F84 (Tanenbaum et al., 2000) l(3)S064301 (Szeged Stock Center, 1998-) l(3)S064316b (Szeged Stock Center, 1998-) l(3)S092416 (Szeged Stock Center, 1998-) l(3)S100201 (Szeged Stock Center, 1998-) l(3)S103505b (Szeged Stock Center, 1998-) mbc (Rushton et al., 1995, Drysdale, 1996.6.25) Miro (Guo et al., 2005) Nup98-96 (Presgraves et al., 2003, Parrott et al., 2011) Rpn9 (Szeged Stock Center, 1998-) sd-3 (Babcock et al., 2003) sgo (Giansanti et al., 2004) small-potatoes (Ghabrial et al., 2011)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	fang (Myat et al., 2005) gim (Myat et al., 2005) gloin (Myat et al., 2005)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Df(3R)mbc-R1 embryos show defects in tracheal cell migration. (Myat et al., 2005) The Df(3R)mbc-R1 chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion). (Mason et al., 2004) Little if any macrophage migration occurs in homozygous embryos, with most macrophages remaining in the anterior region, clustered around the foregut, at stage 13-15. (Paladi and Tepass, 2004) Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome. (Coyne et al., 1998) No eye pigment phenotype in heterozygotes. (Rong and Golic, 1998) Homozygous embryos show a 'dorsal open' phenotype, at least partly accounted for by deletion of the mbc locus. (Drysdale, 1996.6.25)
Stocks ( 2 )
Bloomington	2585 cn¹; Df(3R)mbc-R1, ry⁵⁰⁶/TM3, ry^* Sb¹ Ser¹
Kyoto	107410 cn¹; Df(3R)mbc-R1, ry⁵⁰⁶/TM3, ry^* Sb¹ Ser¹
Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	Df(3R)mbc-p1 (El Chamy et al., 2008) Df(3R)mbc-R (Guo et al., 2005) Df(3R)mbc-R1 (Fullaondo et al., 2011, Parrott et al., 2011, Franklin-Dumont et al., 2007, Paladi and Tepass, 2004, El Chamy et al., 2008, Ghabrial et al., 2011) Df(3R) mbc-R1 (Fiehler and Wolff, 2008) Df(3R)mcb-R1 (Tanenbaum et al., 2000)
Name Synonym
Secondary FlyBase IDs

References ( 28 )

Generate a list of	All references relating to this aberration ( 28 )

List References by type	Research paper ( 25 ) Personal communication to FlyBase ( 1 ) FlyBase analysis ( 1 ) Stock list ( 1 )
Recent research papers ( 3 )
	Fullaondo et al., 2011, Mol. Cell. Biol. 31(14): 2960--2972 Spn1 Regulates the GNBP3-Dependent Toll Signaling Pathway in Drosophila melanogaster. [FBrf0214037] Ghabrial et al., 2011, PLoS Genet. 7(7): e1002087 A systematic screen for tube morphogenesis and branching genes in the Drosophila tracheal system. [FBrf0214368] Parrott et al., 2011, PLoS ONE 6(9): e25087 Nucleoporin98-96 Function Is Required for Transit Amplification Divisions in the Germ Line of Drosophila melanogaster. [FBrf0216255] Show all research papers ...