Aberration Dmel\Df(1)ase-1

General Information
Symbol	Dmel\Df(1)ase-1	Species	D. melanogaster
Name		FlyBase ID	FBab0024326
Feature type	chromosomal_deletion

Computed Breakpoints include
Sequence coordinates
Recent Updates
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FB2012_01
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Aberration
Cytological Order
Progenitor
Mutagen	X ray (Hinz et al., 1994, Carramolino et al., 1982, Gonzalez et al., 1989)
Class of aberration (relative to progenitor)
Breakpoints
Causes alleles	sc^ase-1 (Golovnin et al., 2003, Lindsley and Zimm, 1992)
Carries alleles
Transposon Insertions
Formalized genetic data
Genetic mapping information
Comments	17kb deletion. (Jarman et al., 1993) Deletion of ase and 17kb of flanking sequence. (Gonzalez et al., 1989) Left breakpoint maps between coordinates -10.8 and -13.1 on the ASC map and right breakpoints between -25.8 and -30.7. (Carramolino et al., 1982) 17-19 kb deletion between -11.5 and -30 Df(1)ase-1 mutation is a small deletion from coordinates -11.5 to -30 kb that includes the ase transcription unit, which is located at approximately coordinate -25 kb.
Comments on Cytology
	Deletion of 19kb ASC DNA: the ase coding region and 17kb flanking DNA. (Dominguez and Campuzano, 1993) 17-18kb deletion. (Campuzano et al., 1985) Reported to be a transposition of tip of X to X heterochromatin (Dubinin, 1929). The sc² studied by Sturtevant was not a transposition and mapped as a point mutation at the left end of the X.
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	anon-1Bc (Alonso and Cabrera, 1988) ase (Campuzano et al., 1985, Alonso and Cabrera, 1988, Gonzalez et al., 1989, Dominguez and Campuzano, 1993)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	ac (Campuzano et al., 1985, Alonso and Cabrera, 1988, Gonzalez et al., 1989) anon-1Ba (Alonso and Cabrera, 1988) Cyp4g1 (Campuzano et al., 1985, Alonso and Cabrera, 1988, Gonzalez et al., 1989) l(1)sc (Campuzano et al., 1985, Alonso and Cabrera, 1988, Gonzalez et al., 1989) pcl (Campuzano et al., 1985, Alonso and Cabrera, 1988, Gonzalez et al., 1989) sc (Campuzano et al., 1985, Alonso and Cabrera, 1988, Gonzalez et al., 1989) y (Campuzano et al., 1985, Alonso and Cabrera, 1988, Gonzalez et al., 1989)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Mutant embryos show a low frequency (7% of segments) loss of one chordotonal organ from the lch5 lateral cluster of five chordotonal organs. (zur Lage and Jarman, 2010) Mutants are viable and have normal bristle pigmentation. (Golovnin et al., 2003) Df(1)ase-1 flies have a reduced number of bristles on the anterior wing margin and abdomen, and some wing bristles show differentiation defects. (Klein and Campos-Ortega, 1997) Number of glial cells in Df(1)ase-1 pupal wings is reduced by around 15%. At 13 hours AP several glial cells are evident, unlike for sc^10-1. (Giangrande, 1995) Reduction in number of wing bristles. Remaining bristles may develop abnormally giving rise to split shafts, multiple shafts or empty sockets. The orientation of remaining recurved bristles is often abnormal. Df(1)ase-1;h¹ double mutants have four-fold fewer bristles in the L2 vein than h¹ mutants alone. (Dominguez and Campuzano, 1993) Reduced viability. Reduced number of scutellar and abdominal bristles. Mechanosensory bristles of wing margin deformed, twinned and socketless bristles and bristleless sockets are all observed. Wing blade can be buckled in extremely affected cases. Embryos that lack ase are viable but are missing specific subset of sense organs. (Jarman et al., 1993) Not suppressed by su(Hw)² (E.B. Lewis in FBrf0020044) ase embryos lack a subset of peripheral neurons (FBrf0046281); third instar larvae show disrupted optic-lobe development; in adults almost all abdominal chaetae are removed as are the extra chaetae induced by Tft. Abdomen tends to be swollen; wings poorly expanded; viability of homozygous and hemizygous females low (FBrf0033191). Gene expression first detectable neural primordium, presumably in the neuroblasts. In later embryos, RNA is detected in most cells of the CNS primordium as well as in the labrum, optic lobe rudiment, procephalic neurogenic region and the posterior midgut rudiment. Expression lasts into germ-band retraction. Also expressed sparsely in third instar larvae; scarce in imaginal discs except for one large cell cluster in each leg disk; strong in the CNS, especially in a cap of cells over each optic lobe, which are destined to generate ganglion mother cells of the lamina and medulla; expression also seen in inner anlagen of optic lobes, which give rise to cells of the medulla and lobula complex. Otherwise expression in brain and ventral ganglion occurs in isolated clusters of cells and single cells. Expression thought to identify actively proliferating cells (FBrf0049898).
Stocks ( 3 )
Bloomington	104 Df(1)ase-1, sc^ase-1 pn¹/C(1)DX, y¹ f¹
Kyoto	105737 Df(1)ase-1, sc^ase-1 pn¹/C(1)DX, y¹ f¹ 102029 Df(1)ase-1, sc^ase-1 pn¹ / C(1)DX, y¹ f¹
Notes on Origin
Discoverer	Dubinin, 1928. A. Garcia-Bellido. (Hinz et al., 1994)

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	Df(1)ase-1 was formerly known as sc². (Dominguez and Campuzano, 1993) The adult phenotype, except for the mechanosensory bristle aspect, is due to a perturbation of the nearby sc gene: the defect is not complemented by sc^10-1. The mechanosensory bristle aspect of the phenotype is rescued by the P{ase-G:4.8} and P{ase-G:3.5} constructs. The ventral sensillum campaniformium phenotype is partly rescued. (Jarman et al., 1993)
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	ase¹ (Rawlins et al., 2003, Villa-Cuesta et al., 2003, Klein and Campos-Ortega, 1997, Gomez-Skarmeta et al., 1995, zur Lage and Jarman, 2010) Df(1)ase-1 (Stagg et al., 2011) Df(1)sc² (Skaer and Simpson, 2000, Hinz et al., 1994, Duffy and Gergen, 1991, ) sc² (Golovnin et al., 2003, Gonzalez et al., 1989, Campuzano et al., 1985, Carramolino et al., 1982, Ruiz-Gomez and Ghysen, 1993, )
Name Synonym
Secondary FlyBase IDs
	FBal0000730
References ( 22 )

Generate a list of	All references relating to this aberration ( 22 )

List References by type	Research paper ( 21 ) Book ( 1 )
Recent research papers ( 2 )
	Stagg et al., 2011, Development 138(11): 2171--2183 Dual role for Drosophila lethal of scute in CNS midline precursor formation and dopaminergic neuron and motoneuron cell fate. [FBrf0213671] zur Lage and Jarman, 2010, BMC Dev. Biol. 10: 34 The function and regulation of the bHLH gene, cato, in Drosophila neurogenesis. [FBrf0210540] Show all research papers ...