Aberration Dmel\Df(2R)Pcl^XM82

General Information
Symbol	Dmel\Df(2R)Pcl^XM82	Species	D. melanogaster
Name		FlyBase ID	FBab0024380
Feature type	chromosomal_deletion
Also Known As	Df(2R)Pcl-XM82, Df(2R)XM82

Computed Breakpoints include	55A1;55C1
Deleted segment	55A1--55C1
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Aberration
Cytological Order
Progenitor
Mutagen
Class of aberration (relative to progenitor)	chromosomal_deletion (Tearle, 1996.5.14, Moore, 1999.4.29)
Breakpoints	54D3-54D6;55B7-55B12 (Moore, 1999.4.29) 55A;55B (Tearle, 1996.5.14)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	bk1 << l(2)PC4-D << mama << bk2 << l(2)PC4-R
Genetic mapping information
Comments
Comments on Cytology
	Left limit of break 1 from polytene analysis (FBrf0086812) Right limit of break 1 from inclusion of grh (FBrf0086812) Left limit of break 2 from inclusion of mama (FBrf0086812) Right limit of break 2 from non-inclusion of l(2)PC4-R (FBrf0086812)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	adp (Doane, 1999) eay (Tearle, 1996.5.14) grh (Tearle, 1996.5.14) hal (Tearle, 1996.5.14) l(2)PC4-51 (Tearle, 1996.5.14) l(2)PC4-427 (Tearle, 1996.5.14) l(2)PC4-A (Tearle, 1996.5.14) l(2)PC4-B (Tearle, 1996.5.14) l(2)PC4-C (Tearle, 1996.5.14) l(2)PC4-D (Tearle, 1996.5.14) l(2)PC4-E (Tearle, 1996.5.14) l(2)PC4-F (Tearle, 1996.5.14) l(2)PC4-G (Tearle, 1996.5.14) l(2)PC4-H (Tearle, 1996.5.14) l(2)PC4-K (Tearle, 1996.5.14) l(2)PC4-M (Tearle, 1996.5.14) l(2)PC4-N (Tearle, 1996.5.14) mama (Doane, 1999, Tearle, 1996.5.14) nopo (Merkle et al., 2009) Pcl (Tearle, 1996.5.14) stau (Tearle, 1996.5.14) sub (Giunta et al., 2002, Tearle, 1996.5.14) thr (D'Andrea et al., 1993, Tearle, 1996.5.14)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	fs(2)PC4-U (Tearle, 1996.5.14) l(2)PC4-P (Tearle, 1996.5.14) l(2)PC4-Q (Tearle, 1996.5.14) l(2)PC4-R (Tearle, 1996.5.14) l(2)PC4-S (Tearle, 1996.5.14)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	Fails to complement Df(2R)PC4, Df(2R)Pcl7B and Df(2R)Pcl11B, complements Df(2R)PC29, Df(2R)P34 and Df(2R)PC66. (Tearle, 1996.5.14)
NOT in combination with other aberrations	Completion of mitosis 15 is abnormal, anaphase and telophase figures are not found. CycA and CycB staining reveals chromosome separation (chromosome disjunction) is defective. Entry into the next S phase occurs normally but staining reveals abnormal anaphase and telophase figures. Increase in cell size results from the polyploidisation during the progression through multiple cell cycles lacking chromosome separation and cytokinesis. Despite these abnormalities, major developmental events, such as germband retraction, proceed normally. Cell death occurs at very late stage with a higher frequency in mutants than wild type. The mitotic spindle is not defective in promoting the congression of the mitotic chromosomes into the metaphase plate. Later in mitosis only rudimentary signs of spindle elongation are detected. These irregular extended spindles are not accompanied by separation of the chromosomes. The centriole cycle is not affected. (D'Andrea et al., 1993)
Stocks ( 1 )
Kyoto	101407 CyO, Cy¹ dp^lv1 pr¹ cn² / Df(2R)Pcl^XM82
Notes on Origin
Discoverer	C. Nusslein-Volhard; G. Jurgens. G. Jurgens. (Tearle, 1996.5.14)

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	Df(2R)Pcl^XM82 Df(2R)Pcl-XM82 (Moore, 1999.4.29, Moore, 1997, Tearle, 1996.5.14, Merkle et al., 2009) Df(2R)XM82 (Giunta et al., 2002, D'Andrea et al., 1993) Pcl^XM82
Name Synonym
Secondary FlyBase IDs
	FBal0045001
References ( 9 )
Research paper	Merkle et al., 2009, Development 136(3): 449--459 no poles encodes a predicted E3 ubiquitin ligase required for early embryonic development of Drosophila. [FBrf0206570] Giunta et al., 2002, Genetics 160(4): 1489--1501 subito encodes a kinesin-like protein required for meiotic spindle pole formation in Drosophila melanogaster. [FBrf0147060] Doane, 1999, D. I. S. 82: 53--56 Why is mama not adipose? [FBrf0111850] D'Andrea et al., 1993, Mol. Biol. Cell 4(11): 1161--1174 The three rows gene of Drosophila melanogaster encodes a novel protein that is required for chromosome disjunction during mitosis. [FBrf0065368]
Personal communication to FlyBase	Moore, 1999.4.29, Df(2R)Pcl-XM82 and Df(2R)PC4. Df(2R)Pcl-XM82 and Df(2R)PC4. [FBrf0108500] Tearle, 1996.5.14, [title not yet available] [title not yet available] [FBrf0086812]
FlyBase analysis	FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]
Thesis	Moore, 1997, Ph.D. Thesis, Massachusetts Institute of Technology, MA: 249pp The mechanism of chromosome segregation: genetics and cytology of the Drosophila mutants Dub, mei-S332 and ord. [FBrf0099407]
Stock list	Umea University, 1992-, Umea stocklist. Umea stocklist. [FBrf0084465]

Aberration Dmel\Df(2R)PclXM82

Aberration Dmel\Df(2R)Pcl^XM82