FlyBase Aberration Report: Dmel\Df(2R)wun-GL

General Information

Symbol

Df(2R)wun-GL

Species

D. melanogaster

Name

FlyBase ID

FBab0024400

Feature type

chromosomal_deletion

Also Known As

Df(2R)wun^GL, wun^GL

Computed Breakpoints include

45C8;45D8

Features within 45C8--45D8

Sequence coordinates

Member of large scale dataset(s)

Nature of Aberration

Cytological Order

Progenitor

Mutagen

Class of aberration (relative to wild type)

chromosomal_deletion

(FlyBase, 2007)

Class of aberration (relative to progenitor)

chromosomal_deletion

(Zhang et al., 1996)

Breakpoints

45C8;45D8

(Zhang et al., 1996)

Causes alleles

Carries alleles

Transposon Insertions

Formalized genetic data

Pkn << bk1 << l(2)03659 << wun << bk2 << wun

Genetic mapping information

Comments

Comments on Cytology

Deficient for 45C8;45D8

(Matthews, 1996.2.2)

All limits from polytene analysis (FBrf0089219)

Sequence Crossreferences

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

Gene Deletion and Duplication Data

Genes Deleted / Disrupted

Complementation Data

Completely deleted / disrupted

l(2)03659

(Matthews, 1996.2.2, Zhang et al., 1996)

Myd88

(Charatsi et al., 2003, Tauszig-Delamasure et al., 2002)

Pkn

(Matthews, 1996.2.2, Zhang et al., 1996)

wun

(Sano et al., 2005, Matthews, 1996.2.2, Zhang et al., 1996)

wun2

(Sano et al., 2005, Hanyu-Nakamura et al., 2004)

Partially deleted / disrupted

Molecular Data

Completely deleted

CG12158

(Georgiev et al., 2012)

CG13739

(Georgiev et al., 2012)

CG13954

(Georgiev et al., 2012)

Myd88

(Tauszig-Delamasure et al., 2002)

Non1

(Georgiev et al., 2012)

wun

(Georgiev et al., 2012)

Partially deleted

Genes NOT Deleted / Disrupted

Complementation Data

l(2)gl

(Mason et al., 2004)

Pkn

(Zhang et al., 1996)

su(rdgA)40

(Georgiev et al., 2012)

wun

(Zhang et al., 1996)

Molecular Data

ced-6

(Georgiev et al., 2012)

Pdk

(Georgiev et al., 2012)

Wnt2

(Georgiev et al., 2012)

Genes Duplicated

Complementation Data

Completely duplicated

Partially duplicated

Molecular Data

Completely duplicated

Partially duplicated

Genes NOT Duplicated

Complementation Data

Molecular Data

Affected Genes Inferred by Location (0)

If no genes are listed here, it may be because the affected region is very large. The JBrowse insert above may show an error for the same reason, and other FlyBase tools such as CytoSearch may also fail for large regions. You can contact FlyBase for more help.
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Related Comments

Phenotypic Data

In combination with other aberrations

Df(2R)wun-GL/Df(2R)NYX-D15 double mutants do not exhibit a significant reduction in primordial germ cells (PGCs) during stage 10 of embryogenesis, whereas sibling control embryos exhibit a significant reduction of PGCs during stage 10.

(Sano et al., 2005)

NOT in combination with other aberrations

Primordial germ cells (PGCs) do not form lateral clusters in Df(2R)wun-GL mutants. Instead, PGCs are scattered across the midline and throughout the embryo. PGCs behave differently in Df(2R)wun-GL mutants depending on their location. PGCs in the middle portion of the PMG move toward the mesoderm, but fail to change their position with respect to the midline. PGCs in more lateral regions continue to migrate laterally into the epidermis. PGCs wander for more than 1 hour and fail to form bilateral clusters (in wild-type they form clusters within 40 minutes). Eventually, at a stage when wild-type PGCs have associated with the SGPs, mutant PGCs stop wandering and remain in one location during germ band retraction. While the PGCs do not migrate normally, they form cytoplasmic extensions and migrate as fast as wild-type PGCs.

The morphology of Df(2R)wun-GL PGCs is different to wild-type. PGCs in the middle of Df(2R)wun-GL embryos show more cytoplasmic extensions, including small protrusions, as well as broad cytoplasmic extensions. In Df(2R)wun-GL mutant PGCs, cytoplasmic extensions are transient compared with extensions in wild-type.

(Sano et al., 2005)

Pole cells occasionally aggregate and form pseudo-gonads at the level of the fifth abdominal segment in mutant embryos.

(Marhold et al., 2003)

Hemizygotes are temperature sensitive semi-lethal. Mosaic flies with wild type germ cells and mutant soma have an empty somatic gonad and dispersed germ cells.

(Zhang et al., 1996)

Stocks (2)

Bloomington

w¹¹⁸; Df(2R)wun-GL/CyO

Kyoto

105712

w¹¹⁸; Df(2R)wun-GL/CyO

Notes on Origin

Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

The Df(2R)wun-GL chromosome acts as a dominant weak suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion), but this is a false positive result (the suppressor is not within the bounds of the deficient region) because the region of the deficiency is covered by one or more nonsuppressing deficiencies.

(Mason et al., 2004)

Isolated from the In(2LR)TE35B-15^LL2^R+Df(2R)wun-GL chromosome.

(Matthews, 1996.2.2)

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Df(2R)wun-GL

(Tan et al., 2020, Georgiev et al., 2012, Renault et al., 2010)

Df(2R)wun^GL

(Kenwrick et al., 2019, Haack et al., 2014, Sass and Ostrow, 2014, Ile et al., 2012, Sano et al., 2005, Marhold et al., 2003, Starz-Gaiano et al., 2001, Mukai et al., 1999, Zhang et al., 1996)

Df(2R)wunGL

(Renault et al., 2004, Renault et al., 2004)

Df68

(Tauszig-Delamasure et al., 2002)

wun^GL

(Stepanik et al., 2016, Sano et al., 2005, Ligoxygakis et al., 2001)

Name Synonyms

Secondary FlyBase IDs

References (23)

Report Sections

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