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General Information
Symbol
Dp(1;f)10B
Species
D. melanogaster
Name
FlyBase ID
FBab0024543
Feature type
Also Known As
10B
Computed Breakpoints include
Sequence coordinates
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Class of aberration (relative to wild type)
Class of aberration (relative to progenitor)
Breakpoints
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data
Genetic mapping information
Comments
Comments on Cytology

"Terminal" deletion.

Used in experiments that showed that efficient achiasmate homolog disjunction in female meiosis I requires 1000kb of overlap in the centric heterochromatin and is not affected by homologous euchromatin or overall size differences. Disjunction efficiency decreases linearly as heterochromatic overlap is reduced from 1000 to 430kb. Rescue experiments with nod transgenes showed that heterochromatin does not act solely to promote chromosome movement or spindle attachment. Centric heterochromatin seems to contain multiple pairing elements that act additively to initiate or maintain the proper alignment of achiasmate chromosomes in meiosis I.

Sequence Crossreferences
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
Partially deleted / disrupted
Molecular Data
Completely deleted
Partially deleted
Genes NOT Deleted / Disrupted
Complementation Data
Molecular Data
 
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Phenotypic Data
In combination with other aberrations

Dp(1;f)γ878/Dp(1;f)10B heterozygotes increases y+ expression, to 35% of full Dp(1;f)γ158 trans-suppression. y+ expression is quantitated in triple row bristles.

NOT in combination with other aberrations

Transmission rate through females to progeny is 50% in the first 5 days of egg lay. nod, nod, ncd and Klp3A mutations and mei-S332 ord double mutants cause a mild reduction in transmission. One or two extra copies of nod provided by P{flag-nodhsp} partially rescues transmission.

Stocks (0)
Notes on Origin
Discoverer
 
Balancer / Genotype Variants of the Aberration
 
Separable Components
 
Other Comments
 

Acentric mini-chromosomes are lost at a moderate but elevated rate during male germline mitotic divisions and in female mitosis, but appear to be transmitted efficiently through pre-blastoderm mitoses and male meiosis. mit(1)15 can localise to the mini-chromosome.

Minichromosome is 720bp in length.

Contains 400kb of centric heterochromatin in inverted orientation.

Monosome transmission behaviour from both male and female parents is stable demonstrating normal transmission and normal centromere function.

Synonyms and Secondary IDs (4)
Reported As
Name Synonyms
Secondary FlyBase IDs
  • FBab0026886
References (8)