Aberration Dmel\Df(2L)XE-2750

General Information
Symbol	Dmel\Df(2L)XE-2750	Species	D. melanogaster
Name		FlyBase ID	FBab0024833
Feature type	chromosomal_deletion

Computed Breakpoints include	28A5-28B1;28C1-28C9
Deleted segment	28A5--28C9
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Aberration
Cytological Order
Progenitor
Mutagen	X ray (Wassarman et al., 1996)
Class of aberration (relative to progenitor)	chromosomal_deletion (Wassarman et al., 1996, Prout et al., 1997, Bloomington Drosophila Stock Center, 2003.3.31)
Breakpoints	28A5-28B1;28C1-28C9 (Bloomington Drosophila Stock Center, 2003.3.31) 28B2;28D1 (Prout et al., 1997) 28B2;28D3 (Wassarman et al., 1996)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	bk1 << bub << bk2
Genetic mapping information
Comments
Comments on Cytology
	Likely that 28C7,8 is present. (Bloomington Drosophila Stock Center, 2003.3.31) Limits of break 1 from polytene analysis (FBrf0157294) Limits of break 2 from polytene analysis (FBrf0157294)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	bub (Prout et al., 1997) l(2)k05404 (Spradling et al., 1999, BDGP Project Members, 1994-1999) mts (Spradling et al., 1999, BDGP Project Members, 1994-1999, Wassarman et al., 1996)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	Bsg (BDGP Project Members, 1994-1999, Spradling et al., 1999) Cka (Spradling et al., 1999, BDGP Project Members, 1994-1999) l(2)37Ad (BDGP Project Members, 1994-1999) l(2)k10609 (Spradling et al., 1999, BDGP Project Members, 1994-1999) l(2)k15206 (BDGP Project Members, 1994-1999) l(2)rL220 (BDGP Project Members, 1994-1999) Ndae1 (BDGP Project Members, 1994-1999)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Isolated on the basis of ability to enhance the Ras85D^V12.sev rough eye phenotype. Strong enhancer. Recessive embryonic lethal. (Wassarman et al., 1996)
Stocks ( 2 )
Bloomington	4955 Df(2L)XE-2750/CyO, P{sevRas1.V12}FK1
Kyoto	107968 Df(2L)XE-2750/CyO, P{sevRas1.V12}FK1
Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	The Df(2L)XE-2750 chromosome may act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion), but the eye colour phenotype in the presence of Df(2L)XE-2750 overlaps the eye colour phenotype in a wild-type background so it cannot be unequivocally demonstrated that the deficiency chromosome uncovers a suppressor of telomeric silencing. (Mason et al., 2004) "28A5--B1;28C1--9" was stated as revision. (Bloomington Drosophila Stock Center, 2003.3.31)
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	Df(2L)XE2750 (Prout et al., 1997) Df(2L)XE-2750 (Jordan et al., 2006) Df(2 L)XE-2750 (Munoz-Soriano et al., 2012)
Name Synonym
Secondary FlyBase IDs

References ( 12 )
Research paper	Munoz-Soriano et al., 2012, J. Mol. Neurosci. 48(1): 136--143 Septin 4, the Drosophila Ortholog of Human CDCrel-1, Accumulates in parkin Mutant Brains and is Functionally Related to the Nedd4 E3 Ubiquitin Ligase. [FBrf0219099] Jordan et al., 2006, Genetics 174(1): 271--284 Quantitative trait loci for locomotor behavior in Drosophila melanogaster. [FBrf0193517] Mackay et al., 2005, Genetics 170(4): 1723--1735 Polygenic Mutation in Drosophila melanogaster: mapping Spontaneous Mutations Affecting Sensory Bristle Number. [FBrf0187648] Mason et al., 2004, Genetics 168(3): 1353--1370 A deficiency screen for dominant suppressors of telomeric silencing in Drosophila. [FBrf0180277] Presgraves, 2003, Genetics 163(3): 955--972 A fine-scale genetic analysis of hybrid incompatibilities in Drosophila. [FBrf0158988] Fanara et al., 2002, Genetics 162(3): 1321--1328 Vanaso is a candidate quantitative trait gene for Drosophila olfactory behavior. [FBrf0155481] Spradling et al., 1999, Genetics 153(1): 135--177 The Berkeley Drosophila genome project gene disruption project. Single P-element insertions mutating 25% of vital Drosophila genes. [FBrf0111489] Prout et al., 1997, Genetics 146(1): 275--285 Autosomal mutations affecting adhesion between wing surfaces in Drosophila melanogaster. [FBrf0093664] Wassarman et al., 1996, Genes Dev. 10(3): 272--278 Protein phosphatase 2A positively and negatively regulates Ras1-mediated photoreceptor development in Drosophila. [FBrf0086675]
Personal communication to FlyBase	Bloomington Drosophila Stock Center, 2003.3.31, Revised cytological breakpoints for Df(2L)spd and Df(2L)XE-2750. Revised cytological breakpoints for Df(2L)spd and Df(2L)XE-2750. [FBrf0157294] BDGP Project Members, 1994-1999, BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) [FBrf0067338]
FlyBase analysis	FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]