Aberration Dmel\Df(3R)23D1

General Information
Symbol	Dmel\Df(3R)23D1	Species	D. melanogaster
Name		FlyBase ID	FBab0026863
Feature type	chromosomal_deletion

Computed Breakpoints include	94A3-94A4;94D1-94D4
Deleted segment	94A3--94D4
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Aberration
Cytological Order
Progenitor	P{lacZ-un1}loco^rC56 (Klaembt, 1996.12.4, Granderath et al., 1999)
Mutagen	P-element activity (Klaembt, 1996.12.4)
Class of aberration (relative to progenitor)	chromosomal_deletion (Klaembt, 1996.12.4, Granderath et al., 1999, Cook, 2002.1.18)
Breakpoints	94A3-94A4;94D1-94D4 (Cook, 2002.1.18)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	bk1 << pnt << bk2
Genetic mapping information
Comments
Comments on Cytology
	The deletion removes most of 94D1-4, leaving only a thin portion from the distal edge of the quadruplet. The 94A3,4 doublet is nearly intact. (Cook, 2002.1.18) Breakpoints stated as: 93F;94F (Klaembt, 1996.12.4, Granderath et al., 1999)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	CG34376 (Wang and Montell, 2005) l(3)S091306 (Szeged Stock Center, 1998-) l(3)S092405 (Szeged Stock Center, 1998-) l(3)S101712 (Szeged Stock Center, 1998-) lmd (Ruiz-Gomez et al., 2002) loco (Granderath et al., 1999) pnt (Klaembt, 1996.12.4)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	EP3303 (Wang and Montell, 2005) l(3)S086802 (Szeged Stock Center, 1998-) pinta (Wang and Montell, 2005) pnt (Szeged Stock Center, 1998-) rumi (Acar et al., 2008) tws (Szeged Stock Center, 1998-)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	The distal half of the salivary gland turns but the proximal half does not in embryos homozygous for Df(3R)23D1 by stage 14. (Jattani et al., 2009) Heterozygosity for Df(3R)23D1 results in 3.0% X chromosome nondisjunction and 3.0% fourth chromosome nondisjunction in In(1)FM7/X ; sv^spa-pol females. (Harris et al., 2003) Has a partially penetrant dominant cuticle phenotype. (Cox et al., 2000) Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome. (Coyne et al., 1998)
Stocks ( 1 )
Bloomington	2586 Df(3R)23D1, ry⁵⁰⁶/TM3, Sb¹ Ser¹
Notes on Origin
Discoverer	S. Granderath. (Klaembt, 1996.12.4)

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	"94A3--4;94D1--4" was stated as revision. (Cook, 2002.1.18)
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	Df3R) 23 D1 (Harris et al., 2003) Df(3R)23D1 (Wang and Montell, 2005, Jattani et al., 2009, Lahr et al., 2012)
Name Synonym
Secondary FlyBase IDs

References ( 17 )
Research paper	Lahr et al., 2012, J. Neurosci. 32(20): 6819--6829 Genetic analysis of ecdysis behavior in Drosophila reveals partially overlapping functions of two unrelated neuropeptides. [FBrf0218345] Jattani et al., 2009, Dev. Dyn. 238(4): 853--863 Deficiency screen identifies a novel role for beta 2 tubulin in salivary gland and myoblast migration in the Drosophila embryo. [FBrf0207774] Acar et al., 2008, Cell 132(2): 247--258 Rumi is a CAP10 domain glycosyltransferase that modifies Notch and is required for Notch signaling. [FBrf0204793] Wang and Montell, 2005, J. Neurosci. 25(21): 5187--5194 Rhodopsin formation in Drosophila is dependent on the PINTA retinoid-binding protein. [FBrf0187905] Bach et al., 2003, Genetics 165(3): 1149--1166 A sensitized genetic screen to identify novel regulators and components of the Drosophila janus kinase/signal transducer and activator of transcription pathway. [FBrf0167623] Harris et al., 2003, Genetics 165(2): 637--652 A deficiency screen of the major autosomes identifies a gene (matrimony) that is haplo-insufficient for achiasmate segregation in Drosophila oocytes. [FBrf0167662] Presgraves, 2003, Genetics 163(3): 955--972 A fine-scale genetic analysis of hybrid incompatibilities in Drosophila. [FBrf0158988] Smulders-Srinivasan and Lin, 2003, Genetics 165(4): 1971--1991 Screens for piwi suppressors in Drosophila identify dosage-dependent regulators of germline stem cell division. [FBrf0167655] Ruiz-Gomez et al., 2002, Development 129(1): 133--141 myoblasts incompetent encodes a zinc finger transcription factor required to specify fusion-competent myoblasts in Drosophila. [FBrf0141504] Ashton et al., 2001, Genetics 157(1): 283--294 Quantitative trait loci for the monoamine-related traits heart rate and headless behavior in Drosophila melanogaster. [FBrf0132335] Cox et al., 2000, Genetics 155(4): 1725--1740 A screen for mutations that suppress the phenotype of Drosophila armadillo, the beta-catenin homolog. [FBrf0129777] Granderath et al., 1999, Development 126(8): 1781--1791 loco encodes an RGS protein required for Drosophila glial differentiation. [FBrf0108191] Coyne et al., 1998, Genetics 150(3): 1091--1103 Relative paucity of genes causing inviability in hybrids between Drosophila melanogaster and D. simulans. [FBrf0105213]
Personal communication to FlyBase	Cook, 2002.1.18, Revised cytology of Df(3R)23D1. Revised cytology of Df(3R)23D1. [FBrf0145627] Klaembt, 1996.12.4, Df(3R)23D1 and Df(3R)5C1. Df(3R)23D1 and Df(3R)5C1. [FBrf0091283]
FlyBase analysis	FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]
Stock list	Szeged Stock Center, 1998-, Szeged Stock Center P-element collection. (Computer file) Szeged Stock Center P-element collection. (Computer file) [FBrf0111308]