Aberration Dmel\Df(2R)en^C

General Information
Symbol	Dmel\Df(2R)en^C	Species	D. melanogaster
Name		FlyBase ID	FBab0026999
Feature type	chromosomal_deletion

Computed Breakpoints include
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Aberration
Cytological Order
Progenitor	P{en-lacZ(Xho)}en^Xho25 (Saenz-Robles et al., 1995)
Mutagen	X ray (Saenz-Robles et al., 1995)
Class of aberration (relative to progenitor)
Breakpoints
Causes alleles	en^C (Siegler and Jia, 1999, Gustavson et al., 1996, Saenz-Robles et al., 1995)
Carries alleles
Transposon Insertions
Formalized genetic data
Genetic mapping information
Comments	Deletes en transcription unit, approximate coordinates -12 to -14 of the inv-en region. The deletion removes the entire P{en-lacZ(Xho)} as well as 36 upstream base pairs and extends through the first exon and to within 3bp of the splice acceptor of the first intron. The homeodomain-encoding section of the gene is not deleted. (Gustavson et al., 1996)
Comments on Cytology

Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	en (Saenz-Robles et al., 1995) inv (Saenz-Robles et al., 1995)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	Transheterozygotes with Df(3L)X37 and Df(3L)10^H produce normal flies, transheterozygotes with Df(3L)E13 or Df(3R)slo8 produce flies with abnormal wings. (Saenz-Robles et al., 1995)
NOT in combination with other aberrations
Stocks ( 0 )

Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	Df(2R)en^C Df(2R)enC (Srivastava et al., 2002)
Name Synonym
Secondary FlyBase IDs

References ( 4 )
Research paper	Srivastava et al., 2002, Genome 45(6): 1077--1082 The relationship between the dominant Additional vein mutant in Drosophila melanogaster and engrailed. [FBrf0155819] Siegler and Jia, 1999, Neuron 22(2): 265--276 Engrailed negatively regulates the expression of cell adhesion molecules connectin and neuroglian in embryonic Drosophila nervous system. [FBrf0107991] Gustavson et al., 1996, Genetics 142(3): 893--906 The Drosophila engrailed and invected genes: Partners in regulation, expression and function. [FBrf0086432] Saenz-Robles et al., 1995, Mech. Dev. 53(2): 185--195 Selection and characterization of sequences with high affinity for the engrailed protein of Drosophila. [FBrf0084332]

Aberration Dmel\Df(2R)enC

Aberration Dmel\Df(2R)en^C