Aberration Dmel\Df(3R)nau-11a4

General Information
Symbol	Dmel\Df(3R)nau-11a4	Species	D. melanogaster
Name		FlyBase ID	FBab0028104
Feature type	chromosomal_deletion

Computed Breakpoints include
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Aberration
Cytological Order
Progenitor	P{PZ}Hmgcr⁰¹¹⁵² (Keller et al., 1998)
Mutagen	P-element activity (Keller et al., 1998)
Class of aberration (relative to progenitor)
Breakpoints
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data
Genetic mapping information
Comments
Comments on Cytology
	Deficiency breaks upstream of nau and deletes towards the centromere. (Keller et al., 1998)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	l(3)95Ax (Keller et al., 1998) nau (Keller et al., 1998, Keller et al., 1998)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	Hmgcr (Keller et al., 1998) l(3)95Aa (Keller et al., 1998) l(3)95Ay (Keller et al., 1998) l(3)95Az (Keller et al., 1998) l(3)95Ba (Keller et al., 1998) l(3)95BCa (Keller et al., 1998) l(3)95BCb (Keller et al., 1998) l(3)95BCc (Keller et al., 1998) l(3)95Ca (Keller et al., 1998) mbc (Keller et al., 1998) Nup98-96 (Keller et al., 1998, Presgraves et al., 2003)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	Df(3R)nau-11a4/Df(3R)nau-9 females are sterile; they oviposit at rates equivalent to wild-type, but the eggs are unfertilised. (Balagopalan et al., 2001) Df(3R)nau-11a4/Df(3R)nau-9 embryos are missing a subset of dorsal muscles. These animals survive to adulthood and do not appear to have flight defects. (Keller et al., 1998) Df(3R)nau-11a4/Df(3R)nau-9 transheterozygotes survive to adulthood, at a rate approximating that of the heterozygous Df(3R)nau-11a4 or Df(3R)nau-9 siblings. Df(3R)nau-11a4/Df(3R)nau-9 females can lay eggs, but they do not develop further and appear to be unfertilised. Df(3R)nau-11a4/Df(3R)nau-9 adults have normal flight ability. Df(3R)nau-11a4/Df(3R)nau-9 embryos lack subset of muscle fibres, including the dorsal oblique, dorsal acute and lateral longitudinal muscles. Df(3R)nau-11a4/Df(3R)nau-9 embryos expressing nau^Scer\UAS.cKa under the control of Scer\GAL4^how-24B do not show significant absence of these muscle fibres. Novel muscle fibres are occasionally present in Df(3R)nau-11a4/Df(3R)nau-9 embryos. (Keller et al., 1998)
NOT in combination with other aberrations	Homozygotes hatch into crawling larvae. (Keller et al., 1998)
Stocks ( 0 )

Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	Df(3R)nau-11a4 Df(3R)nau^11a4
Name Synonym
Secondary FlyBase IDs
	FBab0027965
References ( 7 )
Research paper	Presgraves et al., 2003, Nature 423: 715--718 Adaptive evolution drives divergence of a hybrid inviability gene between two species of Drosophila. [FBrf0159638] Presgraves, 2003, Genetics 163(3): 955--972 A fine-scale genetic analysis of hybrid incompatibilities in Drosophila. [FBrf0158988] Balagopalan et al., 2001, Dev. Biol. 231(2): 374--382 Loss-of-function mutations reveal that the Drosophila nautilus gene is not essential for embryonic myogenesis or viability. [FBrf0134546] Keller et al., 1998, Dev. Biol. 202(2): 157--171 A role for nautilus in the differentiation of muscle precursors. [FBrf0105257]
Personal communication to FlyBase	Abmayr, 1998.3.26, nau deficiency names. nau deficiency names. [FBrf0102095]
Abstract	Balagopalan et al., 2000, A. Dros. Res. Conf. 41: 479A The mutant phenotype of nautilus. [FBrf0126288] Keller et al., 1998, A. Dros. Res. Conf. 39: 57 The nautilus gene is essential for the formation of a subset of muscles. [FBrf0101095]