Aberration Dmel\Df(3R)HTRI

General Information
Symbol	Dmel\Df(3R)HTRI	Species	D. melanogaster
Name		FlyBase ID	FBab0028923
Feature type	chromosomal_deletion

Computed Breakpoints include
Deleted segment	82C4--82D5
Sequence coordinates
Recent Updates
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FB2012_01
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Aberration
Cytological Order
Progenitor	P{lacW}l(3)j4D1^j4D1 (Colas et al., 1999)
Mutagen	P-element activity (Colas et al., 1999)
Class of aberration (relative to progenitor)	chromosomal_deletion (Colas et al., 1999)
Breakpoints	82C4;82D4-82D5 (Colas et al., 1999)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data
Genetic mapping information
Comments
Comments on Cytology

Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	5-HT2 (Colas et al., 1999, Colas et al., 1999, Schaerlinger et al., 2007) Karyβ3 (Colas et al., 1999, Schaerlinger et al., 2007) l(3)10112 (Colas et al., 1999) Rpp30 (Colas et al., 1999) shk (Colas et al., 1999)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	atms (Colas et al., 1999) l(3)02733 (Colas et al., 1999)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Homozygous lethal. Mutant embryos show abnormal germband extension movements. There is a desynchronization between germband extension and mesodermal and endodermal invaginations, and a premature termination of movements. The ventral midline closure is often incomplete. At apparent stage 7, the ectodermal cells of homozygous embryos have a round apex, presenting only few intercellular connecting structures. Cell adhesion is impaired. The apical projections of the cells are reduced and the apico-basal localisation of junctional structures is altered. (Colas et al., 1999) In homozygous embryos the pushing force generated by ectodermal cell intercalation is impaired or lacking. Germband extension is desynchronized from mesoderm and endoderm invaginations. Germband extension arrests, and defects in ventral midlien closure occur. The phenotype is variable, some embryos arrest at very early stages. Other embryos develop further and show a "double line" denticle belt phenotype. Some embryos hatch to first instar larvae. (Colas et al., 1999)
Stocks ( 1 )
Bloomington	24507 Df(3R)HTRI/TM3, P{Thb8-lacZ}WD1, Sb¹ Ser¹
Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Df(3R)HTRI (Schaerlinger et al., 2007)
Name Synonym
Secondary FlyBase IDs

References ( 4 )
Research paper	Schaerlinger et al., 2007, Dev. Dynamics 236(4): 991--999 Gain of affinity point mutation in the serotonin receptor gene 5-HT(2Dro) accelerates germband extension movements during Drosophila gastrulation. [FBrf0194099] Colas et al., 1999, Mech. Dev. 87(1-2): 77--91 Serotonin synchronises convergent extension of ectoderm with morphogenetic gastrulation movements in Drosophila. [FBrf0111346] Colas et al., 1999, Mech. Dev. 87(1-2): 67--76 Maternal and zygotic control of serotonin biosynthesis are both necessary for Drosophila germband extension. [FBrf0111347]
FlyBase analysis	FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]