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General Information
Symbol
Ab(Y)Y146
Species
D. melanogaster
Name
FlyBase ID
FBab0029421
Computed Breakpoints include
Sequence coordinates
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Class of aberration (relative to wild type)
Class of aberration (relative to progenitor)
Breakpoints
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data
Genetic mapping information
Comments
Comments on Cytology

New order: h1-h21 | h4-h1 (a duplication of h1-h4 and a deletion of h22-h25).

Sequence Crossreferences
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
Partially deleted / disrupted
Molecular Data
Completely deleted
Partially deleted
Genes NOT Deleted / Disrupted
Complementation Data
 
Molecular Data
 
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location
    Phenotypic Data
    In combination with other aberrations

    X/Ab(Y)Y146/Dp(1;Y)y+ males are sterile. Testes show a departure from normal development at early postmeiotic stages of spermatid differentiation. Before nuclear elongation, round spermatid nuclei begin to fall apart in a large number of spermatid bundles, resulting in singular nuclei heads that are dispersed throughout the tails. In approximately 10% of males, the testes contain exclusively round spermatids scattered throughout the length of the tails. Many of the spermatid bundles with scattered nuclei are much smaller in diameter than normal, suggesting that some of the spermatid tails fail to develop. However, some spermatid bundles show aligned nuclear heads associated with individualisation complexes, as in wild type. C(1;YS)1/Ab(Y)Y146 males are fertile. Ab(Y)Y146 is not complemented by Ts(1Rt;YSt)V8. Ab(Y)Y146 is complemented by Ts(1Rt;YSt)W19. Ts(1Lt;YSt)P7/Ab(Y)Y146 males produce large numbers of progeny, comparable to wild-type X/Y males. Ts(1Lt;YSt)W27/Ab(Y)Y146 males produce large numbers of progeny, comparable to wild-type X/Y males. Ts(1Lt;YSt)V24/Ab(Y)Y146 males show a significant reduction in male fertility compared to wild type; 19% of males fail to produce any progeny, 46% produce very small numbers of progeny (less than 40/male) and only 10% produce more than 80 progeny/male. Postmeiotic defects are seen in the testes; spermatid bundles with scattered singular nuclear heads are seen frequently, but account only for a small proportion of spermatid bundles. Some individualisation complexes are located away from the nuclear bundles, apparently resulting from caudal movement along the tails (as occurs in wild type). Individualised spermatids are seen in the basal region of the testes and mature sperm are seen in the seminal vesicles.

    NOT in combination with other aberrations
    Stocks (0)
    Notes on Origin
    Discoverer
     
    Balancer / Genotype Variants of the Aberration
     
    Separable Components
     
    Other Comments
     
    Synonyms and Secondary IDs (2)
    Reported As
    Symbol Synonym
    Name Synonyms
    Secondary FlyBase IDs
      References (1)