Aberration Dmel\Df(2R)BSC22

General Information
Symbol	Dmel\Df(2R)BSC22	Species	D. melanogaster
Name		FlyBase ID	FBab0029834
Feature type	chromosomal_deletion

Computed Breakpoints include
Deleted segment	56D7--56F12
Sequence coordinates
Member of large scale dataset(s)	Dfs_BSC_set1 A set of ~50 targeted deficiencies created by exploiting hybrid element insertion (HEI) and resolution; designed to fill gaps in deletion coverage. (Parks et al., 2004)
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Aberration
Cytological Order
Progenitor	P{EP}βTub56D^EP2640 (Deal-Herr and Cook, 2002.9.10, Parks et al., 2004) P{PZ}mus209⁰²⁴⁴⁸ (Deal-Herr and Cook, 2002.9.10, Parks et al., 2004)
Mutagen	Delta2-3 (Deal-Herr and Cook, 2002.9.10) recombination (Deal-Herr and Cook, 2002.9.10)
Class of aberration (relative to progenitor)	chromosomal_deletion (Deal-Herr and Cook, 2002.9.10, Parks et al., 2004)
Breakpoints	56D7-56E3;56F9-56F12 (Deal-Herr and Cook, 2002.9.10, Parks et al., 2004)
Causes alleles
Carries alleles	bw⁺ (Deal-Herr and Cook, 2002.9.10)
Transposon Insertions
Formalized genetic data
Genetic mapping information
Comments
Comments on Cytology

Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	18w (Deal-Herr and Cook, 2002.9.10) l(2)k00705 (Deal-Herr and Cook, 2002.9.10) par-1 (McDonald et al., 2008) TBCB (Baffet et al., 2012)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	Inferred to overlap with: Df(2R)BSC782. (Christensen et al., 2009.5.6) Inferred to overlap with: Df(2R)BSC594. (Christensen et al., 2008.9.3)
NOT in combination with other aberrations
Stocks ( 2 )
Bloomington	6647 Df(2R)BSC22/SM6a
Kyoto	130322 Df(2R)BSC22/SM6a
Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	The miniwhite marker from P{EP}βTub56D^EP2640 was deleted or disrupted. (Mason, 2004.11.26) The Df(2R)BSC22 chromosome may act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion), but the eye colour phenotype in the presence of Df(2R)BSC22 overlaps the eye colour phenotype in a wild-type background so it cannot be unequivocally demonstrated that the deficiency chromosome uncovers a suppressor of telomeric silencing. (Mason et al., 2004)
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Df(2R)BSC22 (O'Farrell et al., 2008, Nakamoto et al., 2012, Christensen et al., 2008.9.3, McDonald et al., 2008, Christensen et al., 2009.5.6, Baffet et al., 2012, Yagi et al., 2010, Yuan et al., 2012)
Name Synonym
Secondary FlyBase IDs

References ( 15 )
Research paper	Baffet et al., 2012, Mol. Biol. Cell 23(18): 3591--3601 Drosophila tubulin-binding cofactor B is required for microtubule network formation and for cell polarity. [FBrf0219447] Nakamoto et al., 2012, Immunity 36(4): 658--667 Virus recognition by toll-7 activates antiviral autophagy in Drosophila. [FBrf0218107] Yuan et al., 2012, Dev. Biol. 361(1): 57--67 Regulation of cyclin A localization downstream of Par-1 function is critical for the centrosome orientation checkpoint in Drosophila male germline stem cells. [FBrf0216861] Yagi et al., 2010, Dev. Growth Differ. 52(9): 771--783 Functional analysis of Toll-related genes in Drosophila. [FBrf0212564] McDonald et al., 2008, Curr. Biol. 18(21): 1659--1667 PAR-1 Kinase Regulates Epithelial Detachment and Directional Protrusion of Migrating Border Cells. [FBrf0206227] O'Farrell et al., 2008, Dev. Dyn. 237(1): 196--208 Regulation of the Drosophila lin-41 homologue dappled by let-7 reveals conservation of a regulatory mechanism within the LIN-41 subclade. [FBrf0201979] Mason et al., 2004, Genetics 168(3): 1353--1370 A deficiency screen for dominant suppressors of telomeric silencing in Drosophila. [FBrf0180277] Parks et al., 2004, Nat. Genet. 36(3): 288--292 Systematic generation of high-resolution deletion coverage of the Drosophila melanogaster genome. [FBrf0175003]
Supplementary material	Parks et al., 2004, Nature Genetics 36(3): Supplementary Table 1: Deletions generated at Bloomington between trans-heterozygous P element insertions. [FBrf0179070]
Personal communication to FlyBase	Christensen et al., 2009.5.6, Isolation and characterization of Df(2R)BSC782. Isolation and characterization of Df(2R)BSC782. [FBrf0207868] Christensen et al., 2008.9.3, Isolation and characterization of Df(2R)BSC594. Isolation and characterization of Df(2R)BSC594. [FBrf0205638] Mason, 2004.11.26, Miniwhite in BSC deletions. Miniwhite in BSC deletions. [FBrf0179886] Deal-Herr and Cook, 2002.9.10, Isolation and characterization of Df(2R)BSC22. Isolation and characterization of Df(2R)BSC22. [FBrf0151661]
FlyBase analysis	Millburn et al., 2012.8.1, Lines in aberration datasets (files on ftp site). Lines in aberration datasets (files on ftp site). [FBrf0219195] FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]