Aberration Dmel\Df(3L)ban^Δ1

General Information
Symbol	Dmel\Df(3L)ban^Δ1	Species	D. melanogaster
Name		FlyBase ID	FBab0029992
Feature type	chromosomal_deletion
Also Known As	ban^Δ1, bantam^Δ1

Computed Breakpoints include
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Aberration
Cytological Order
Progenitor	P{EP}ban^EP3622a (Hipfner et al., 2002) P{EP}ban^EP3622b (Hipfner et al., 2002)
Mutagen	P-element activity (Hipfner et al., 2002)
Class of aberration (relative to progenitor)
Breakpoints
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data
Genetic mapping information
Comments
Comments on Cytology

Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	ban (Hipfner et al., 2002, Bilen et al., 2006) EP3219 (Hipfner et al., 2002)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	Fails to complement: Df(3L)Ar11. (Hipfner et al., 2002)
NOT in combination with other aberrations	There is no obvious improvement in axon regeneration of class IV da neurons in the ventral nerve cord (after axon severing at the commissure junction at 48 hours after egg laying) in mutant larvae compared to wild type controls. The dendrites of ddaC neurons of mutant larvae show enhanced regeneration (after dendrite severing at 48 hours after egg laying) compared to wild-type controls. 81.2% of dendrites show regeneration in the mutant larvae (compared to 49.4% in controls). No substantial dendrite regeneration is seen after dendrite severing at 72 hours after egg laying. (Song et al., 2012) Df(3L)ban[Δ1] mutant larvae show a decrease in the number of glial cells in the eye disc and brain. (Reddy and Irvine, 2011) Df(3L)ban[Δ1] mutants display a dendrite overgrowth phenotype with the first sign of larval growth defects at 72 hours after egg laying. Dendrites of individual class IV neurons occupy a larger proportion of the body wall in Df(3L)ban[Δ1] mutant third instar larvae. Dendrites in Df(3L)ban[Δ1] mutants promiscuously cross boundaries that are observed by dendrites of wild-type neurons. The exuberant growth of dendrites in Df(3L)ban[Δ1] mutants is manifested throughout the arbor, not just at the boundaries. In addition to these defects in dendrite coverage, class IV neurons in Df(3L)ban[Δ1] mutants show significant increase in the number of dendrites, the density of dendrites, and overall dendrite length. Class III dendrites are defective in scaling of dendrite growth to hemisegment size in Df(3L)ban[Δ1] mutants. In contrast, larval class I dendrites show no obvious defects in dendrite coverage in Df(3L)ban[Δ1] mutants. Unlike wild-type controls, following ablation at 48 hours after egg laying, dendrites in Df(3L)ban[Δ1] mutants extensively fill unoccupied space. Loss of ban function in homozygous Df(3L)ban[Δ1] mutant sensory neuron clones has no significant effect on dendrite coverage of class IV neurons. (Parrish et al., 2009) Df(3L)ban[Δ1] heterozygotes show significantly reduced eclosion after irradiation with 0-8000 R of X-rays. A W[05014] heterozygous background suppresses lethality found in Df(3L)ban[Δ1] mutants to generate wild-type levels of survival when larvae are irradiated with 0-8000 R of X-rays. (Jaklevic et al., 2008) Df(3L)ban[Δ1] mutant germline stem cells (GSCs) generated during the adult stages show maintenance and cell division defects, with loss of approximately 14% of Df(3L)ban[Δ1] mutant GSCs per day. When Df(3L)ban[Δ1] clones are generated during the larval and pupal stages GSC loss is less severe, with loss of only around 6% of GSCs per day. (Shcherbata et al., 2007) Df(3L)ban^Δ1 mutant clones are very small compared to their sister twinspots when induced at 60 hours of development and examined in the late third instar. Df(3L)ban^Δ1 clones remain relatively small even when given a growth advantage using the Minute technique. These clones do not induce a rough eye phenotype and show no evidence of increased apoptosis when induced in the wing. (Thompson and Cohen, 2006) When Df(3L)ban^Δ1 somatic clones are made in the wing disc, they are on average 1/3 of the size of wild-type twins. No obvious increase in apoptosis is seen in these clones. (Brennecke et al., 2003) The body mass of heterozygotes is 89% that of control flies. The wing blade surface area is 94.9% that of controls. Cell size in the wing blade is 100.5% of controls and cell number in the wing blade is 94.4% that of controls. (Raisin et al., 2003) Homozygotes die at early pupal stages. Homozygous larvae lack detectable imaginal discs. (Hipfner et al., 2002)
Stocks ( 0 )

Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	21,147bp deletion generated by imprecise excision of the P{EP}EP1090 elements in the "EP(3)3622" line (P{EPg}ban^EPg30491a and P{EPg}ban^EPg30491b). (Hipfner et al., 2002)
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	ban¹ (Richter et al., 2011) ban^delta1 (Nolo et al., 2006) ban^Δ1 (Raisin et al., 2003, Brennecke et al., 2003, Hipfner et al., 2002, Thompson and Cohen, 2006, Becam et al., 2011, Parrish et al., 2009, Jaklevic et al., 2008, Kagey et al., 2012, Reddy and Irvine, 2011, Song et al., 2012) bantam^D1 (Becam et al., 2011) bantam^Δ1 (Becam et al., 2011, Herranz et al., 2010) banΔ1 (Thompson and Cohen, 2006) Df(3L)ban^Δ1 (Bilen et al., 2006, Shcherbata et al., 2007)
Name Synonym
Secondary FlyBase IDs

References ( 15 )
Research paper	Kagey et al., 2012, Mech. Dev. 129(9-12): 339--349 Regulation of Yorkie activity in Drosophila imaginal discs by the Hedgehog receptor gene patched. [FBrf0219794] Song et al., 2012, Genes Dev. 26(14): 1612--1625 Regeneration of Drosophila sensory neuron axons and dendrites is regulated by the Akt pathway involving Pten and microRNA bantam. [FBrf0218927] Becam et al., 2011, Development 138(17): 3781--3789 Notch-mediated repression of bantam miRNA contributes to boundary formation in the Drosophila wing. [FBrf0214603] Reddy and Irvine, 2011, Development 138(23): 5201--5212 Regulation of Drosophila glial cell proliferation by Merlin-Hippo signaling. [FBrf0216584] Richter et al., 2011, Nat. Cell Biol. 13(9): 1029--1039 The tumour suppressor L(3)mbt inhibits neuroepithelial proliferation and acts on insulator elements. [FBrf0215050] Herranz et al., 2010, EMBO J. 29(10): 1688--1698 The miRNA machinery targets Mei-P26 and regulates Myc protein levels in the Drosophila wing. [FBrf0210816] Parrish et al., 2009, Neuron 63(6): 788--802 The microRNA bantam functions in epithelial cells to regulate scaling growth of dendrite arbors in drosophila sensory neurons. [FBrf0208858] Jaklevic et al., 2008, Dev. Biol. 320(1): 122--130 Modulation of ionizing radiation-induced apoptosis by bantam microRNA in Drosophila. [FBrf0207139] Shcherbata et al., 2007, Cell Stem Cell 1(6): 698--709 Stage-specific differences in the requirements for germline stem cell maintenance in the Drosophila ovary. [FBrf0202622] Bilen et al., 2006, Mol. Cell 24(1): 157--163 MicroRNA pathways modulate polyglutamine-induced neurodegeneration. [FBrf0192284] Nolo et al., 2006, Curr. Biol. 16(19): 1895--1904 The bantam microRNA is a target of the hippo tumor-suppressor pathway. [FBrf0194704] Thompson and Cohen, 2006, Cell 126(4): 767--774 The hippo pathway regulates the bantam microRNA to control cell proliferation and apoptosis in Drosophila. [FBrf0193861] Brennecke et al., 2003, Cell 113(1): 25--36 bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila. [FBrf0158764] Raisin et al., 2003, Genetics 164(3): 1015--1025 A new genetic locus controlling growth and proliferation in Drosophila melanogaster. [FBrf0160859] Hipfner et al., 2002, Genetics 161(4): 1527--1537 The bantam gene regulates Drosophila growth. [FBrf0152024]

Aberration Dmel\Df(3L)banΔ1

Aberration Dmel\Df(3L)ban^Δ1