Aberration Dmel\Df(1)ED7364

General Information
Symbol	Dmel\Df(1)ED7364	Species	D. melanogaster
Name		FlyBase ID	FBab0030975
Feature type	chromosomal_deletion

Computed Breakpoints include	[14A8-14A8];[14C6-14C6];
Deleted segment	14A8--14C6
Map ( GBrowse )	Untitled Document
Sequence coordinates	X:15,985,520..15,985,520 (Df(1)ED7364:bk1) (DrosDel Project, 2007.6.25) X:16,340,978..16,340,978 (Df(1)ED7364:bk2) (DrosDel Project, 2007.6.25)
Member of large scale dataset(s)	Dfs_DrosDel_set1 A set of isogenic deficiency stocks created by FLP-induced recombination between FRT-carrying transgenic insertions; molecularly defined deletion endpoints correspond to initial location of the progenitor insertions. Initial core set of 209 isogenic deletions provides ~60% euchromatic genome coverage. (Ryder et al., 2007)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Nature of the Aberration
Cytological Order
Progenitor
Mutagen
Class of aberration (relative to progenitor)	chromosomal_deletion (Ryder, 2003.6.17)
Breakpoints	14A8;14C6 (FlyBase Curators, 2008)
Causes alleles
Carries alleles
Transposon Insertions	P{3'.RS5+3.3'}ED7364 (FlyBase, 1992-)
Formalized genetic data
Genetic mapping information
Comments
Comments on Cytology
	Limits of break 1 computationally determined from location of progenitor P insertion on genome sequence between P{EP}Gβ13F^EP1071 and P{EP}EP1458&P{EP}EP1522 Limits of break 2 computationally determined from location of progenitor P insertion on genome sequence between P{EP}EP1547^EP1547 and P{EP}CG4928^EP1341
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Molecular Data
Completely deleted	eIF-2α (Marygold et al., 2007) rngo (Marygold et al., 2007)
Genes NOT Deleted / Disrupted
Complementation Data
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	The Minute phenotype of Df(1)ED7364/+ flies can be rescued using Dp(1;1)FDDP-0024486. (Marygold et al., 2007)
NOT in combination with other aberrations	Heterozygous Df(1)ED7364 mutant females exhibit a dilated cardiomyopathy phenotype, including an increased end-systolic dimension (EDD) and a decreased fractional shortening (FS) compared to controls. Bristles appear short and thin compared to wild type (Minute phenotype). (Casad et al., 2011) Df(1)ED7364/+ flies show a Minute phenotype. (Marygold et al., 2007)
Stocks ( 3 )
Bloomington	9905 Df(1)ED7364, w¹¹¹⁸ P{3'.RS5+3.3'}ED7364/FM7h 32529 Dp(1;Y)BSC240, y⁺ P{3'.RS5+3.3'}BSC33, B^S/Df(1)ED7364, w¹¹¹⁸ P{3'.RS5+3.3'}ED7364/C(1)RA, In(1)sc^J1, In(1)sc⁸, l(1)1Ac¹, sc^J1 sc⁸
Kyoto	150258 w¹¹¹⁸ Df(1)ED7364 / FM7h
Notes on Origin
Discoverer
	Potential deficiency; could be generated as the recombinant product between the reduced derivatives of P{RS3}CB-0360-3 and P{RS5}5-HA-1790. (Ryder, 2003.6.17)
Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Df(1)ED7364 (FlyBase Curators, 2008, Marygold et al., 2007, Casad et al., 2011)
Name Synonym
Secondary FlyBase IDs

References ( 10 )
Research paper	Casad et al., 2011, Genetics 189(3): 861--870 Cardiomyopathy Is Associated with Ribosomal Protein Gene Haplo-Insufficiency in Drosophila melanogaster. [FBrf0216591] Marygold et al., 2007, Genome Biol. 8(10): R216 The ribosomal protein genes and Minute loci of Drosophila melanogaster. [FBrf0205398] Ryder et al., 2007, Genetics 177(1): 615--629 The DrosDel deletion collection: a Drosophila genomewide chromosomal deficiency resource. [FBrf0202170]
Personal communication to FlyBase	DrosDel Project, 2007.6.25, DrosDel deletion data mapped to Release 5.1 (updated 2007-06-25). DrosDel deletion data mapped to Release 5.1 (updated 2007-06-25). [FBrf0205060] Ryder and Roote, 2005.11.4, Update from DrosDel Database - Release 4 mappings - November 2005. Update from DrosDel Database - Release 4 mappings - November 2005. [FBrf0188738] Ryder, 2003.6.17, Drosdel deletions. Drosdel deletions. [FBrf0161091]
FlyBase analysis	Millburn et al., 2012.8.1, Lines in aberration datasets (files on ftp site). Lines in aberration datasets (files on ftp site). [FBrf0219195] FlyBase Curators, 2008, Release 5 estimated cytology of aberrations with sequence-defined breakpoints. Release 5 estimated cytology of aberrations with sequence-defined breakpoints. [FBrf0206255] FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808] FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]