Aberration Dmel\Df(2R)ex8

General Information
Symbol	Dmel\Df(2R)ex8	Species	D. melanogaster
Name		FlyBase ID	FBab0037749
Feature type	chromosomal_deletion

Computed Breakpoints include
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Aberration
Cytological Order
Progenitor	P{lacW}3A2 (Davis et al., 2003) P{lacW}F5 (Davis et al., 2003)
Mutagen	Delta2-3 (Davis et al., 2003)
Class of aberration (relative to progenitor)
Breakpoints
Causes alleles	Act57B^ex8 (Davis et al., 2003)
Carries alleles
Transposon Insertions
Formalized genetic data
Genetic mapping information
Comments
Comments on Cytology

Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	Rx (Davis et al., 2003)
Partially deleted / disrupted	Act57B (Davis et al., 2003)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	The majority of Df(2R)ex8 homozygotes fail to eclose, and die as pharate adults. Rare escaper adults fail to unfold their wings and do not survive beyond 48 hours. However, artificial unfolding of these wings shows that they have no gross structural defects. The eyes and ocelli of these escaper adults are normal, but these animals lack a clypeus. Sectioning of the heads of escaper adults reveals that cibarial plates are present, as well as the anterior apodeme. However, the musculature is disorganized and does not appear to be consistently attached to the apodeme. In the brains of Df(2R)ex8 homozygous larvae, the ellipsoid body (EB) is abnormal. The observed phenotypes fall into three classes: The most severe "unfused" phenotype, where termini fail to intersect at the midline, is observed in over half of the mutants (57%); A less severe "elongated" phenotype is seen in one-third of the mutants, where the EB processes cross the midline, but are abnormal in width (28%); The least severe "ventral" phenotype, where the EB width is normal, but the ventral processes fail to close the rings, is also the least frequent (15%). Df(2R)ex8 homozygous larvae behave normally in phototaxis assays. (Davis et al., 2003)
Stocks ( 0 )

Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	Deletion generated by Δ2-3 induced excision of P{lacW}F5 and P{lacW}3A2 present on the same chromosome. Loss of Rx sequence has been confirmed by PCR. Southern blots and PCR analyses are consistent with deletion of all sequence between these two P-elements, but not of flanking sequence (CG9235 and Act57B remain intact.) (Davis et al., 2003)
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	Df(2R)ex8 Rx^ex8 (Davis et al., 2003)
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Davis et al., 2003, Dev. Biol. 259(2): 272--287 Drosophila retinal homeobox (drx) is not required for establishment of the visual system, but is required for brain and clypeus development. [FBrf0160472]