Aberration Dmel\Df(2R)Exel6065

General Information
Symbol	Dmel\Df(2R)Exel6065	Species	D. melanogaster
Name		FlyBase ID	FBab0038003
Feature type	chromosomal_deletion

Computed Breakpoints include	[53D14-53D14];[53F8-53F8];
Deleted segment	53D14--53F8
Map ( GBrowse )	Untitled Document
Sequence coordinates	2R:12,744,683..12,744,683 (Df(2R)Exel6065:bk1) (Bloomington Drosophila Stock Center, 2008.8.7) 2R:12,985,001..12,985,001 (Df(2R)Exel6065:bk2) (Bloomington Drosophila Stock Center, 2008.8.7)
Member of large scale dataset(s)	Dfs_Exelixis_set1 A set of isogenic deficiency stocks created by FLP-induced recombination between FRT-carrying transgenic insertions; molecularly defined deletion endpoints correspond to initial location of the progenitor insertions. Initial set of 519 isogenic deletions provides 56% genome coverage. The current Exelixis collection at the Bloomington Stock Center differs from the original described in FBrf0175003: a significant number were shown not to carry a deletion and have been removed from the collection; a number of stocks have been lost; a number of additional deletions are included that were generated after publication. (Parks et al., 2004, Cook, 2012.9.12)
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Aberration
Cytological Order
Progenitor	P{XP}d07507 (Parks et al., 2004) P{XP}Dek^d07106 (Parks et al., 2004)
Mutagen	FLPase (Parks et al., 2004)
Class of aberration (relative to progenitor)	chromosomal_deletion (Parks et al., 2004)
Breakpoints	53D14;53F8 (FlyBase Curators, 2008) 53D14;53F9 (Parks et al., 2004)
Causes alleles
Carries alleles	w⁺ (Parks et al., 2004)
Transposon Insertions	P{XP-U}Exel6065 (Parks et al., 2004)
Formalized genetic data
Genetic mapping information
Comments
Comments on Cytology

Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	Ehbp1 (Giagtzoglou et al., 2012) mute (Bulchand et al., 2010)
Molecular Data
Completely deleted	Ark (Ryder, 2004.4.26) Cbp53E (Ryder, 2004.4.26) CG6421 (Ryder, 2004.4.26) CG6426 (Ryder, 2004.4.26) CG6429 (Ryder, 2004.4.26) CG6435 (Ryder, 2004.4.26) CG6472 (Ryder, 2004.4.26) CG6665 (Ryder, 2004.4.26) CG6796 (Ryder, 2004.4.26) CG6805 (Ryder, 2004.4.26) CG6967 (Ryder, 2004.4.26) CG6984 (Ryder, 2004.4.26) CG8910 (Ryder, 2004.4.26) CG8950 (Ryder, 2004.4.26) CG8963 (Ryder, 2004.4.26) CG9010 (Ryder, 2004.4.26) CG9640 (Ryder, 2004.4.26) CG9642 (Ryder, 2004.4.26) CG9646 (Ryder, 2004.4.26) CG15614 (Ryder, 2004.4.26) CG30460 (Ryder, 2004.4.26) CR30461 (Ryder, 2004.4.26) Ef1β (Ryder, 2004.4.26) Ehbp1 (Ryder, 2004.4.26) fat-spondin (Ryder, 2004.4.26) GstS1 (Ryder, 2004.4.26) inaC (Ryder, 2004.4.26) NiPp1 (Ryder, 2004.4.26) Pkc53E (Ryder, 2004.4.26) Psi (Ryder, 2004.4.26) RhoGEF2 (Ryder, 2004.4.26) Sply (Ryder, 2004.4.26) ste24a (Ryder, 2004.4.26) ste24b (Ryder, 2004.4.26) ste24c (Ryder, 2004.4.26) tef (Ryder, 2004.4.26) tRNA:G3:53E (Ryder, 2004.4.26) Vha16-4 (Ryder, 2004.4.26)
Genes NOT Deleted / Disrupted
Complementation Data
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	In Df(2R)Exel6065 homozygous embryos, a significant proportion of migrating germ cells fail to associate with the developing somatic gonad. (Ricardo and Lehmann, 2009)
Stocks ( 1 )
Bloomington	7547 w¹¹¹⁸; Df(2R)Exel6065, P{XP-U}Exel6065/CyO
Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	Df(2R)Dmel\ste24 (Ricardo and Lehmann, 2009) Df(2R)Exel6065 (FlyBase Curators, 2008, Giagtzoglou et al., 2012, Adolphsen et al., 2012, Ricardo and Lehmann, 2009) Df(2R)Exel 6065 (Bulchand et al., 2010)
Name Synonym
Secondary FlyBase IDs

References ( 13 )
Research paper	Adolphsen et al., 2012, G3 (Bethesda) 2(6): 629--642 Type-I Prenyl Protease Function Is Required in the Male Germline of Drosophila melanogaster. [FBrf0218548] Giagtzoglou et al., 2012, J. Cell Biol. 196(1): 65--83 dEHBP1 Controls Exocytosis and Recycling of Delta During Asymmetric Divisions. [FBrf0217836] Bulchand et al., 2010, J. Cell Sci. 123(16): 2697--2707 Muscle wasted: a novel component of the Drosophila histone locus body required for muscle integrity. [FBrf0211459] Ricardo and Lehmann, 2009, Science 323(5916): 943--946 An ABC transporter controls export of a Drosophila germ cell attractant. [FBrf0206762] Parks et al., 2004, Nat. Genet. 36(3): 288--292 Systematic generation of high-resolution deletion coverage of the Drosophila melanogaster genome. [FBrf0175003]
Supplementary material	Ricardo and Lehmann, 2009, Science 323(5916): An ABC Transporter Controls Export of a Drosophila Germ Cell Attractant. [FBrf0207632] Parks et al., 2004, Nature Genetics 36(3): Supplementary Table 2. [FBrf0174230]
Personal communication to FlyBase	Cook, 2012.9.12, Notes on the Exelixis deletion collection. Notes on the Exelixis deletion collection. [FBrf0219608] Bloomington Drosophila Stock Center, 2008.8.7, Release 5 sequence coordinates of Exelixis deficiencies. Release 5 sequence coordinates of Exelixis deficiencies. [FBrf0205061] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
FlyBase analysis	Millburn et al., 2012.8.1, Lines in aberration datasets (files on ftp site). Lines in aberration datasets (files on ftp site). [FBrf0219195] FlyBase Curators, 2008, Release 5 estimated cytology of aberrations with sequence-defined breakpoints. Release 5 estimated cytology of aberrations with sequence-defined breakpoints. [FBrf0206255] FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]