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General Information
Symbol
Df(2R)Exel6070
Species
D. melanogaster
Name
FlyBase ID
FBab0038008
Feature type
Computed Breakpoints include
[57A6-57A6];[57B3-57B3];
Deleted Segment
Sequence coordinates
2R:20,582,780..20,582,780 (Df(2R)Exel6070:bk1)
2R:20,836,033..20,836,033 (Df(2R)Exel6070:bk2)
Member of large scale dataset(s)
Dfs_Exelixis_set1
A set of isogenic deficiency stocks created by FLP-induced recombination between FRT-carrying transgenic insertions; molecularly defined deletion endpoints correspond to initial location of the progenitor insertions. Initial set of 519 isogenic deletions provides 56% genome coverage.
The current Exelixis collection at the Bloomington Stock Center differs from the original described in FBrf0175003 : a significant number were shown not to carry a deletion and have been removed from the collection; a number of stocks have been lost; a number of additional deletions are included that were generated after publication.
Nature of Aberration
Cytological Order
Progenitor
Class of aberration (relative to wild type)
Class of aberration (relative to progenitor)
Breakpoints
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data
Genetic mapping information
Comments
Breakpoint based on release 3 sequence coordinate from Parks et al., 2004 (FBrf0174230), converted to release 5 coordinate.
Comments on Cytology
Limits computationally determined from location of progenitor P insertion on genome sequence between P{lacW}l(2)k06409k06409&P{PZ}insc05475 and P{PZ}l(2)0780607806
Sequence Crossreferences
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Genes NOT Deleted / Disrupted
Complementation Data
 
Molecular Data
 
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Phenotypic Data
In combination with other aberrations
Lethal in combination with Df(2R)BSC402.
Df(2R)KT40/Df(2R)Exel6070 transheterozygotes show excessive or disorganized basal stalk cells, mis-shaped follicle cells, a multilayered follicular epithelium and/or aberrant nurse cell number, as compared to controls; the multilayering is virtually absent under starvation conditions. Under starvation, these transheterozygotes show a significant increase in the mitotic index of the follicular epithelium, as compared to controls.
The aforementioned defects are strongly rescued by the adulthood-only expression of either hhHMS00492 or Rab23JF02859 under the control of Scer\GAL4bab1-Pgal4-2 (and Gal80[ts] for temporal control of expression).
Df(2R)KT40/Df(2R)Exel6070 mutant brains contain an increased number of M-phase neuroblasts per lobe compared to controls.
Inferred to overlap with: Df(2R)BSC403.
NOT in combination with other aberrations
Stocks (1)
Notes on Origin
Discoverer
 
Balancer / Genotype Variants of the Aberration
 
Separable Components
 
Other Comments
 
Synonyms and Secondary IDs (3)
References (13)