A set of isogenic deficiency stocks created by FLP-induced recombination between FRT-carrying transgenic insertions; molecularly defined deletion endpoints correspond to initial location of the progenitor insertions. Initial set of 519 isogenic deletions provides 56% genome coverage.
The current Exelixis collection at the Bloomington Stock Center differs from the original described in FBrf0175003 : a significant number were shown not to carry a deletion and have been removed from the collection; a number of stocks have been lost; a number of additional deletions are included that were generated after publication.
Df(2R)Exel7166 embryos have significantly reduced neuroblast and daughter proliferation in the brain and significantly reduced numbers of neuroblasts, including type II neuroblasts, compared to controls; this does not affect the anterior dorsomedial cluster.
Df(2R)Exel7166 heterozygotes show a dominant electrophysiological impairment in mini amplitude.
Dominantly modifies the size of pupae relative to wild-type controls.