Aberration Dmel\Df(3L)Exel6106

General Information
Symbol	Dmel\Df(3L)Exel6106	Species	D. melanogaster
Name		FlyBase ID	FBab0038126
Feature type	chromosomal_deletion

Computed Breakpoints include	[64D6-64D6];[64E2-64E2];
Deleted segment	64D6--64E2
Map ( GBrowse )	Untitled Document
Sequence coordinates	3L:5,601,375..5,601,375 (Df(3L)Exel6106:bk1) (Bloomington Drosophila Stock Center, 2008.8.7) 3L:5,684,102..5,684,102 (Df(3L)Exel6106:bk2) (Bloomington Drosophila Stock Center, 2008.8.7)
Member of large scale dataset(s)	Dfs_Exelixis_set1 A set of isogenic deficiency stocks created by FLP-induced recombination between FRT-carrying transgenic insertions; molecularly defined deletion endpoints correspond to initial location of the progenitor insertions. Initial set of 519 isogenic deletions provides 56% genome coverage. The current Exelixis collection at the Bloomington Stock Center differs from the original described in FBrf0175003: a significant number were shown not to carry a deletion and have been removed from the collection; a number of stocks have been lost; a number of additional deletions are included that were generated after publication. (Parks et al., 2004, Cook, 2012.9.12)
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Aberration
Cytological Order
Progenitor	P{XP}Eaf6^d06605 (Parks et al., 2004) P{XP}sif^d08550 (Parks et al., 2004)
Mutagen	FLPase (Parks et al., 2004)
Class of aberration (relative to progenitor)	chromosomal_deletion (Parks et al., 2004)
Breakpoints	64D6;64E2 (Parks et al., 2004, FlyBase Curators, 2008)
Causes alleles
Carries alleles	w⁺ (Parks et al., 2004)
Transposon Insertions	P{XP-U}Exel6106 (Parks et al., 2004)
Formalized genetic data
Genetic mapping information
Comments
Comments on Cytology
	Limits computationally determined from location of progenitor P insertion on genome sequence between P{PZ}sinu⁰⁶⁵²⁴ and P{PZ}Bre1⁰¹⁶⁴⁰
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Molecular Data
Completely deleted	Blimp-1 (Ryder, 2004.4.26) lin-28 (Ryder, 2004.4.26) Sse (Ryder, 2004.4.26)
Genes NOT Deleted / Disrupted
Complementation Data
	l(3)psg2 (Wang et al., 2008)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Mutants show embryonic lethality. Mutant embryos do not show any significant defects in segmentation or in the development of the peripheral nervous system. However, the mutant embryos show a striking tracheal phenotype at stage 16; the dorsal tracheal trunk is severely misshapen and appears like a string of sausages instead of the regular tube that is characteristic of wild-type embryos. The taenidial folds of the lumenal surface of the dorsal trunk are dramatically reduced compared to wild type and are irregular in the mutant embryos. The gross organisation of the epithelial layer of the dorsal trunk is perturbed in homozygous mutant embryos, particularly at the junctions and the tracheal cells have a larger and rounder shape in the mutant embryos compared to wild type. (Ng et al., 2006)
Stocks ( 1 )
Bloomington	7585 w¹¹¹⁸; Df(3L)Exel6106, P{XP-U}Exel6106/TM6B, Tb¹
Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Df(3L)Exel6106 (Ng et al., 2006, FlyBase Curators, 2008, Edwards and Mackay, 2009, Wang et al., 2008, Slack et al., 2006)
Name Synonym
Secondary FlyBase IDs

References ( 12 )
Research paper	Edwards and Mackay, 2009, Genetics 182(3): 889--897 Quantitative Trait Loci for Aggressive Behavior in Drosophila melanogaster. [FBrf0208371] Wang et al., 2008, Genetics 180(1): 269--281 A genetic screen identifies new regulators of steroid-triggered programmed cell death in Drosophila. [FBrf0207097] Ng et al., 2006, Dev. Genes Evol. 216(5): 243--252 A homologue of the vertebrate SET domain and zinc finger protein Blimp-1 regulates terminal differentiation of the tracheal system in the Drosophila embryo. [FBrf0190256] Slack et al., 2006, BMC Genet. 7: 33 A mosaic genetic screen for novel mutations affecting Drosophila neuroblast divisions. [FBrf0192335] Parks et al., 2004, Nat. Genet. 36(3): 288--292 Systematic generation of high-resolution deletion coverage of the Drosophila melanogaster genome. [FBrf0175003]
Supplementary material	Parks et al., 2004, Nature Genetics 36(3): Supplementary Table 2. [FBrf0174230]
Personal communication to FlyBase	Cook, 2012.9.12, Notes on the Exelixis deletion collection. Notes on the Exelixis deletion collection. [FBrf0219608] Bloomington Drosophila Stock Center, 2008.8.7, Release 5 sequence coordinates of Exelixis deficiencies. Release 5 sequence coordinates of Exelixis deficiencies. [FBrf0205061] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
FlyBase analysis	Millburn et al., 2012.8.1, Lines in aberration datasets (files on ftp site). Lines in aberration datasets (files on ftp site). [FBrf0219195] FlyBase Curators, 2008, Release 5 estimated cytology of aberrations with sequence-defined breakpoints. Release 5 estimated cytology of aberrations with sequence-defined breakpoints. [FBrf0206255] FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]