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General Information
Symbol
Df(3R)Exel6191
Species
D. melanogaster
Name
FlyBase ID
FBab0038246
Feature type
Computed Breakpoints include
[94A6-94A6];[94B2-94B2];
Deleted Segment
Sequence coordinates
3R:22,367,973..22,367,973 (Df(3R)Exel6191:bk1)
3R:22,530,780..22,530,780 (Df(3R)Exel6191:bk2)
Member of large scale dataset(s)
Dfs_Exelixis_set1
A set of isogenic deficiency stocks created by FLP-induced recombination between FRT-carrying transgenic insertions; molecularly defined deletion endpoints correspond to initial location of the progenitor insertions. Initial set of 519 isogenic deletions provides 56% genome coverage.
The current Exelixis collection at the Bloomington Stock Center differs from the original described in FBrf0175003 : a significant number were shown not to carry a deletion and have been removed from the collection; a number of stocks have been lost; a number of additional deletions are included that were generated after publication.
Nature of Aberration
Cytological Order
Progenitor
Class of aberration (relative to wild type)
Class of aberration (relative to progenitor)
Breakpoints
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data
Genetic mapping information
Comments
Breakpoint based on release 3 sequence coordinate from Parks et al., 2004 (FBrf0174230), converted to release 5 coordinate.
Comments on Cytology
Sequence Crossreferences
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations
Neuromuscular junction (NMJ) synapses appear relatively normal ultrastructurally in homozygous embryos, except that pre- and postsynaptic densities are incompletely apposed. The number of synaptic vesicles, dense core vesicles, active zone diameter and postsynaptic density diameter are all statistically indistinguishable from wild type. NMJ size and the number of active zones/NMJ are significantly reduced in the homozygous embryos compared to wild type. The amplitude of the evoked excitatory junction current (EJC) is reduced in homozygous embryonic NMJs compared to wild type, while the frequency of spontaneous EJCs is unaffected. There is no change in the amplitude of glutamate-gated currents at the NMJ in these embryos.
Stocks (1)
Notes on Origin
Discoverer
 
Balancer / Genotype Variants of the Aberration
 
Separable Components
 
Other Comments
 
Synonyms and Secondary IDs (4)
References (21)