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General Information
Symbol
Df(3R)Exel6198
Species
D. melanogaster
Name
FlyBase ID
FBab0038253
Feature type
Computed Breakpoints include

[95E1-95E1];[95F8-95F8];

Deleted Segment
Sequence coordinates
3R:24,141,369..24,141,369 (Df(3R)Exel6198:bk1)
3R:24,271,205..24,271,205 (Df(3R)Exel6198:bk2)
Member of large scale dataset(s)
Dfs_Exelixis_set1

A set of isogenic deficiency stocks created by FLP-induced recombination between FRT-carrying transgenic insertions; molecularly defined deletion endpoints correspond to initial location of the progenitor insertions. Initial set of 519 isogenic deletions provides 56% genome coverage.

The current Exelixis collection at the Bloomington Stock Center differs from the original described in FBrf0175003 : a significant number were shown not to carry a deletion and have been removed from the collection; a number of stocks have been lost; a number of additional deletions are included that were generated after publication.

Nature of Aberration
Cytological Order
Class of aberration (relative to wild type)
Class of aberration (relative to progenitor)
Breakpoints
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data
Genetic mapping information
Comments

Breakpoint from FlyBase's release 5 sequence location of progenitor insertion.

This deletion removes a single ribosomal protein-coding gene (though other genes are also removed).

Comments on Cytology

Limits computationally determined from location of progenitor P insertion on genome sequence between P{PZ}Syx1A06737/P{PZ}Syx1A10660 and P{PZ}crb07207&P{PZ}BRWD305842

Sequence Crossreferences
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Genes NOT Deleted / Disrupted
Complementation Data
Molecular Data
 
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations

The fertility of ms(3)K81T:Avic\GFP/+;Df(3R)ms(3)K81-2/Df(3R)ms(3)K81-2 as well as cavHipHop.T:Avic\GFP/Y;cav1/+ adult males is normal, males of the combined genotype cavHipHop.T:Avic\GFP/Y;ms(3)K81T:Avic\GFP/+;cav1,Df(3R)ms(3)K81-2/Df(3R)ms(3)K81-2 display only slight decrease in fertility but this is dramatically enhanced by combination with Df(3R)Exel6198 - cavHipHop.T:Avic\GFP/Y;ms(3)K81T:Avic\GFP/+;cav1,Df(3R)ms(3)K81-2/Df(3R)Exel6198,Df(3R)ms(3)K81-2 males are almost completely sterile.

The slightly reduced fertility of cavHipHop.T:Avic\GFP/Y;cav1/Df(3R)Exel6198 adult (cav1 rescue) males is significantly enhanced by combination with Df(3R)ms(3)K81-2 and also by combination with HipHop1 albeit less strongly. The fertility of cavHipHop.T:Avic\GFP/Y;cav1,Df(3R)ms(3)K81-2/HipHop1,Df(3R)Exel6198 males is intermediate to that of cavHipHop.T:Avic\GFP/Y;cav1/Df(3R)Exel6198 males combined with either the Df(3R)ms(3)K81-2 or the HipHop1 allele alone.

The increased number of abnormal spermatid nuclei (showing chromatin bridges) characteristic for adult cavHipHop.T:Avic\GFP;cav1/Df(3R)Exel6198 males is strongly enhanced by combination with Df(3R)ms(3)K81-2 in homozygous or, to a lesser degree, in heterozygous state. Enhancement of the abnormal nuclear phenotype is also observed upon combination with single copy of HipHop1 as well as verS147910 but the phenotype is not aggravated further by combination with heterozygous moi1 allele.

Flies heterozygous for the deletion do not show a Minute bristle phenotype.

Stocks (1)
Notes on Origin
Discoverer
 
Balancer / Genotype Variants of the Aberration
 
Separable Components
 
Other Comments
 
Synonyms and Secondary IDs (1)
References (18)