Aberration Dmel\Df(2L)k07716-V.1

General Information
Symbol	Dmel\Df(2L)k07716-V.1	Species	D. melanogaster
Name		FlyBase ID	FBab0038762
Feature type	chromosomal_deletion

Computed Breakpoints include
Deleted segment	32E2--32E2
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Aberration
Cytological Order
Progenitor	P{lacW}cana^k07716 (Ciapponi et al., 2004)
Mutagen	P-element activity (Ciapponi et al., 2004)
Class of aberration (relative to progenitor)	chromosomal_deletion (Ciapponi et al., 2004)
Breakpoints	[];[] (Ciapponi et al., 2004)
Causes alleles	cana^k07716-V.1 (Ciapponi et al., 2004)
Carries alleles
Transposon Insertions
Formalized genetic data
Genetic mapping information
Comments
Comments on Cytology

Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Molecular Data
Completely deleted	mre11 (Ciapponi et al., 2004) Osi21 (Ciapponi et al., 2004) Ppt2 (Ciapponi et al., 2004) salr (Ciapponi et al., 2004)
Partially deleted	cana (Ciapponi et al., 2004)
Genes NOT Deleted / Disrupted
Complementation Data
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments
	150kb deletion. (Ciapponi et al., 2004)
Phenotypic Data
In combination with other aberrations	Lethal in combination with Df(2L)FCK-20. Df(2L)FCK-20/Df(2L)k07716-V.1 animals die at the pupal stage and no adult escapers are seen. The mutant pharate adults have rough eyes, scalloped wings and bristles are shorter than normal or missing. Wings discs of mutant third instar larvae show high levels of apoptosis compared to control discs. Mitotic neuroblasts from Df(2L)FCK-20/Df(2L)k07716-V.1 larval brains show a high frequency of telomere fusions and chromosome breaks. Single telomeric associations (in which a single telomere fuses with either its sister telomere or a single non-sister telomere) and double telomere associations are seen. Metaphases with rearranged chromosomes and hyperploid/polyploid cells are seen. Chromosome breaks involving either one or both sister chromatids are seen. Df(2L)FCK-20/Df(2L)k07716-V.1 mutant cells are at least one order of magnitude more sensitive than wild-type cells to the induction of chromosome breaks by irradiation. (Ciapponi et al., 2004)
NOT in combination with other aberrations
Stocks ( 0 )

Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	FlyBase curator comment: The combination Df(2L)FCK-20/Df(2L)k07716-V.1 is referred to as "mre11^DC". (Ciapponi et al., 2006)
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	Df(2L)K07716-V.1 (Ciapponi et al., 2004) Df(2L)k07716-V.1
Name Synonym
Secondary FlyBase IDs

References ( 3 )
Research paper	Ciapponi et al., 2006, Genetics 173(3): 1447--1454 The Drosophila Nbs protein functions in multiple pathways for the maintenance of genome stability. [FBrf0194855] Ciapponi et al., 2004, Curr. Biol. 14(15): 1360--1366 The Drosophila Mre11/Rad50 complex is required to prevent both telomeric fusion and chromosome breakage. [FBrf0180055]
FlyBase analysis	FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]