Aberration Dmel\Df(2L)x528

General Information
Symbol	Dmel\Df(2L)x528	Species	D. melanogaster
Name		FlyBase ID	FBab0041478
Feature type	chromosomal_deletion

Computed Breakpoints include
Deleted segment	25E1--25E2
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Aberration
Cytological Order
Progenitor	P{PZ}H-15 (Miskolczi-McCallum et al., 2005)
Mutagen	X ray (Buescher et al., 2004, Miskolczi-McCallum et al., 2005)
Class of aberration (relative to progenitor)	chromosomal_deletion (Buescher et al., 2004)
Breakpoints	[];[] (Buescher et al., 2004)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data
Genetic mapping information
Comments
Comments on Cytology

Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	CR31647 (Miskolczi-McCallum et al., 2005) H15 (Miskolczi-McCallum et al., 2005) mid (Miskolczi-McCallum et al., 2005)
Molecular Data
Completely deleted	CR31647 (Buescher et al., 2004, Leal et al., 2009) H15 (Buescher et al., 2004, Leal et al., 2009) mid (Buescher et al., 2004, Leal et al., 2009)
Genes NOT Deleted / Disrupted
Complementation Data
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	Embryos trans-heterozygous for Df(2L)sc19-4 and Df(2L)x528 yield an abnormal neuronal cell fate specification phenotype identical to that observed for embryos homozygous for Df(2L)sc19-4. (Leal et al., 2009) Inferred to overlap with: Df(2L)sc19-4. (Leal et al., 2009) Df(2L)x528/Df(2L)GpdhA embryos show a loss of neuroblasts NB1-1, NB2-5 and NB2-4. This loss is much more pronounced in odd-numbered than even-numbered abdominal segments. However, the loss is similar to mid mutants, suggesting that the it is deletion of the mid gene and not the H15 gene that is causing the phenotype. (Buescher et al., 2006) Inferred to overlap with: Df(2L)GpdhA. (Miskolczi-McCallum et al., 2005) Df(2L)GpdhA/Df(2L)x528 larvae show a loss of denticle belts; denticle rows 1 to 5 are frequently lost in odd-numbered segments, whereas even-numbered segments show milder defects. (Buescher et al., 2004)
NOT in combination with other aberrations
Stocks ( 0 )

Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Df(2L)x528 (Buescher et al., 2006, Leal et al., 2009)
Name Synonym
Secondary FlyBase IDs

References ( 5 )
Research paper	Leal et al., 2009, Dev. Biol. 325(1): 138--150 Neuromancer1 and Neuromancer2 regulate cell fate specification in the developing embryonic CNS of Drosophila melanogaster. [FBrf0207072] Buescher et al., 2006, Dev. Biol. 292(2): 418--429 Functions of the segment polarity genes midline and H15 in Drosophila melanogaster neurogenesis. [FBrf0190096] Miskolczi-McCallum et al., 2005, Dev. Biol. 278(2): 459--472 The Drosophila melanogaster T-box genes midline and H15 are conserved regulators of heart development. [FBrf0183853] Buescher et al., 2004, Curr. Biol. 14(19): 1694--1702 Drosophila T box proteins break the symmetry of hedgehog-dependent activation of wingless. [FBrf0180065]
FlyBase analysis	FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]