Df(2R)mir-7-Δ1/Df(2R)exu1 suppresses wing notching seen in N55e11/+ flies. N55e11/+, ct6/+, and Scer\GAL4sd.PU>dapHMS01610 suppresses the severity of decreases in wing size seen in Df(2R)mir-7-Δ1/Df(2R)exu1 flies.
Adult Df(2R)mir-7-Δ1/Df(2R)exu1 escapers (around 55% die during embryonic development, 30% during larval development) have wing phenotypes. Wing size is classified into different severities (class 1 show 55-65% size reduction, class 2 a 45-55% reduction, class 3 a 35-45% reduction) and these occur in different frequencies: class 1 32.5%, class 2 45%, class 3 22.5%. The density of trichomes in Df(2R)mir-7-Δ1/Df(2R)exu1 wings
is significantly higher than wild type (mutant wing cells after pupal development are smaller than wild type wing cells). Df(2R)mir-7-Δ1/Df(2R)exu1 wing discs show a shift in cell cycle phasing, with an increased fraction of cells in GO/G1 (problems with transition of G1 to S phase of the cell cycle).
The nascent Johnston's organ appears normal in antennal discs from Df(2R)mir-7-Δ1/Df(2R)exu1 mutants grown under fluctuating temperature conditions, but the arista sensory organ precursor (SOP) group fails to form and the number of SOPs that form the coeloconic sensillae are reduced, with those that do develop being abnormally patterned.