Aberration Dmel\Df(3L)Brd-C1

General Information
Symbol	Dmel\Df(3L)Brd-C1	Species	D. melanogaster
Name		FlyBase ID	FBab0045446
Feature type	chromosomal_deletion

Computed Breakpoints include
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Aberration
Cytological Order
Progenitor	P{XP}d02180 (Bardin and Schweisguth, 2006) PBac{WH}DCX-EMAP^f02655 (Bardin and Schweisguth, 2006)
Mutagen	FLPase (Bardin and Schweisguth, 2006)
Class of aberration (relative to progenitor)	chromosomal_deletion (Bardin and Schweisguth, 2006)
Breakpoints
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data
Genetic mapping information
Comments	A 38Kb deletion generated by 'FLPase' induced recombination between the insertions P{XP}d02180 and PBac{WH}CG42247^f02655. (Bardin and Schweisguth, 2006)
Comments on Cytology

Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Molecular Data
Partially deleted	DCX-EMAP (Bardin and Schweisguth, 2006, Chanet et al., 2009)
Completely deleted	BobA (Chanet et al., 2009) BobB (Chanet et al., 2009) Brd (Chanet et al., 2009) Ocho (Chanet et al., 2009) Tom (Chanet et al., 2009)
Genes NOT Deleted / Disrupted
Complementation Data
Molecular Data
	CG3349 (Chanet et al., 2009)
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	39% of embryos homozygous for the Df(3L)Brd-C1 and Df(3R)E(spl)δ-6 deletions and carrying one copy of Dp(3;2)E(spl)δ-8 fail to hatch and only 2% reach pupal stages. (Chanet et al., 2009) DCX-EMAP[tCa] does not rescue the lethality of Df(3L)Brd-C1. (Chanet et al., 2009) Animals homozygous for the Df(3L)Brd-C1 and Df(3R)E(spl)δ-6 deletions and carrying one copy of Dp(3;2)E(spl)δ-8Δα46 are 100% embryonic lethal. (Chanet et al., 2009) The lethality of Df(3L)Brd-C1 is partially rescued by Dp(3;2)Brd-C; 20% of embryos develop into adult flies that are fertile. (Chanet et al., 2009)
NOT in combination with other aberrations	60% of mutant animals die as embryos, and only 6% reach adulthood. Homozygous clones in the notum do not perturb bristle development. (Chanet et al., 2009)
Stocks ( 0 )

Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	Df(3)Brd-C1 (Chanet et al., 2009) Df(3L)Brd-C1 (Bardin and Schweisguth, 2006)
Name Synonym
Secondary FlyBase IDs

References ( 2 )
Research paper	Chanet et al., 2009, Genetics 182(4): 1101--1108 Genome engineering-based analysis of bearded family genes reveals both functional redundancy and a nonessential function in lateral inhibition in Drosophila. [FBrf0208667] Bardin and Schweisguth, 2006, Dev. Cell 10(2): 245--255 Bearded family members inhibit Neuralized-mediated endocytosis and signaling activity of Delta in Drosophila. [FBrf0190191]