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General Information
Symbol
Df(2R)mir-309-6Δ1
Species
D. melanogaster
Name
FlyBase ID
FBab0046035
Feature type
Also Known As
miR-309-6Δ1
Computed Breakpoints include
Sequence coordinates
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
Class of aberration (relative to wild type)
Class of aberration (relative to progenitor)
Breakpoints
Causes alleles
Carries alleles
Formalized genetic data
Genetic mapping information
Comments

Ends-out homologous recombination has resulted in 1.1kb comprising the "mir-309" cluster containing eight miRNA genes (mir-6-3, mir-6-2, mir-6-1, mir-5, mir-4, mir-286, mir-3 and mir-309) being replaced with a Avic\GFP marker.

Comments on Cytology
Sequence Crossreferences
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
Partially deleted / disrupted
Molecular Data
Partially deleted
Genes NOT Deleted / Disrupted
Complementation Data
 
Molecular Data
 
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Phenotypic Data
In combination with other aberrations

Df(2R)mir-309-6Δ1/Df(2R)ED3728 animals show partial lethality. Df(2R)mir-309-6Δ1/Df(2R)ED3728 embryos show a significant increase in primordial germ cell number compared to controls.

NOT in combination with other aberrations

Homozygotes show partial lethality. Homozygous males and females are fertile.

Homozygous Df(2R)mir-309-6Δ1 animals show a modest reduction in viability to adulthood. Homozygous Df(2R)mir-309-6Δ1 mutants show little or no reduction in the completion of embryogenesis compared to controls.

Homozygotes complete embryogenesis with no apparent defects in patterning, but approximately 20% die as larvae at different larval stages. Some animals stop growing at the size of second instar larvae and arrest at this stage for a few days before dying. Approximately 80% of homozygotes survive to adulthood and are viable and fertile. The mutant animals show a developmental delay during larval stages.

Stocks (1)
Notes on Origin
Discoverer
 
Balancer / Genotype Variants of the Aberration
 
Separable Components
 
Other Comments
 
Synonyms and Secondary IDs (5)
Reported As
Symbol Synonym
Df(2R)mir-309-6Δ1
miR-309-6Δ1
mir-309-C delta 1
Name Synonyms
Secondary FlyBase IDs
    References (5)