|Computed Breakpoints include|
|Member of large scale dataset(s)|
What does this section display?
This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).
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|Nature of the Aberration|
|Class of aberration (relative to progenitor)|
|Formalized genetic data|
|Genetic mapping information|
|Comments on Cytology|
|Gene Deletion & Duplication Data|
|Genes Deleted / Disrupted|
|Genes NOT Deleted / Disrupted|
|Genes NOT Duplicated|
|In combination with other aberrations|
Df(3R)RhoGAP100F[ex1.2]/Df(3R)RhoGAP100F[ex3.4] adults appear morphologically normal and under optimal culturing conditions, eclose at close to the Mendelian ratio. However, more than 80% of the adults die within one week. The adult flies show severely impaired locomotion (assayed both by walking ability on a flat surface and in a negative geotaxis assay).
Evoked excitatory junctional currents (EJCs) are significantly reduced in amplitude in Df(3R)RhoGAP100F[ex1.2]/Df(3R)RhoGAP100F[ex3.4] third instar larvae compared to controls, while the amplitude of spontaneous miniature EJCs is normal.
The overall size of the neuromuscular junction (NMJ) is reduced in Df(3R)RhoGAP100F[ex1.2]/Df(3R)RhoGAP100F[ex3.4] third instar larvae compared to controls. Ultrastructurally, T bars at the NMJ often appear irregular in shape, with pedestals of very high diameter and multiple, atypically prominent filamentous projections in their distal parts. In addition, atypically small T bar-like assemblies are seen. Ectopic electron-dense material is seen at the mutant NMJ, frequently being seen at the edge of active zones and only loosely, if at all, being associated with the presynaptic plasma membrane. Floating electron-dense material, highly decorated with synaptic vesicles, is seen in the bouton interior.
|NOT in combination with other aberrations|
|Stocks ( 0 )|
|Notes on Origin|
|Balancer / Genotype Variants of the Aberration|
|Synonyms & Secondary IDs ( 2 )|
|Secondary FlyBase IDs|
|References ( 1 )|