Aberration Dmel\Df(3R)RhoGAP100F^ex3.4

General Information
Symbol	Dmel\Df(3R)RhoGAP100F^ex3.4	Species	D. melanogaster
Name		FlyBase ID	FBab0047211
Feature type	chromosomal_deletion

Computed Breakpoints include
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Aberration
Cytological Order
Progenitor	P{XP}heph^d09905 (Owald et al., 2010) PBac{WH}f02651 (Owald et al., 2010)
Mutagen	FLPase (Owald et al., 2010)
Class of aberration (relative to progenitor)	chromosomal_deletion (Owald et al., 2010)
Breakpoints
Causes alleles	heph^ex3.4 (Owald et al., 2010)
Carries alleles
Transposon Insertions
Formalized genetic data
Genetic mapping information
Comments	Scer\FRT-mediated recombination between the two progenitor insertions has deleted the sequence between them. (Owald et al., 2010)
Comments on Cytology

Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Molecular Data
Completely deleted	RhoGAP100F (Owald et al., 2010)
Partially deleted	heph (Owald et al., 2010)
Genes NOT Deleted / Disrupted
Complementation Data
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	Df(3R)RhoGAP100F[ex1.2]/Df(3R)RhoGAP100F[ex3.4] adults appear morphologically normal and under optimal culturing conditions, eclose at close to the Mendelian ratio. However, more than 80% of the adults die within one week. The adult flies show severely impaired locomotion (assayed both by walking ability on a flat surface and in a negative geotaxis assay). (Owald et al., 2010) Evoked excitatory junctional currents (EJCs) are significantly reduced in amplitude in Df(3R)RhoGAP100F[ex1.2]/Df(3R)RhoGAP100F[ex3.4] third instar larvae compared to controls, while the amplitude of spontaneous miniature EJCs is normal. (Owald et al., 2010) The overall size of the neuromuscular junction (NMJ) is reduced in Df(3R)RhoGAP100F[ex1.2]/Df(3R)RhoGAP100F[ex3.4] third instar larvae compared to controls. Ultrastructurally, T bars at the NMJ often appear irregular in shape, with pedestals of very high diameter and multiple, atypically prominent filamentous projections in their distal parts. In addition, atypically small T bar-like assemblies are seen. Ectopic electron-dense material is seen at the mutant NMJ, frequently being seen at the edge of active zones and only loosely, if at all, being associated with the presynaptic plasma membrane. Floating electron-dense material, highly decorated with synaptic vesicles, is seen in the bouton interior. (Owald et al., 2010)
NOT in combination with other aberrations
Stocks ( 0 )

Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	Df(3R)RhoGAP100F^ex3.4 dsyd-1^ex3.4 (Owald et al., 2010)
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Owald et al., 2010, J. Cell Biol. 188(4): 565--579 A Syd-1 homologue regulates pre- and postsynaptic maturation in Drosophila. [FBrf0210057]

Aberration Dmel\Df(3R)RhoGAP100Fex3.4

Aberration Dmel\Df(3R)RhoGAP100F^ex3.4