Aberration Dmel\Df(2L)His^C

General Information
Symbol	Dmel\Df(2L)His^C	Species	D. melanogaster
Name		FlyBase ID	FBab0047224
Feature type	chromosomal_deletion

Computed Breakpoints include
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Aberration
Cytological Order
Progenitor	P{RS3}CB-5033-3 (Günesdogan et al., 2010) P{RS5}Lamp1^5-HA-1581 (Günesdogan et al., 2010)
Mutagen	FLPase (Günesdogan et al., 2010)
Class of aberration (relative to progenitor)	chromosomal_deletion (Günesdogan et al., 2010)
Breakpoints
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data
Genetic mapping information
Comments	Scer\FRT-mediated recombination between the two progenitor insertions has resulted in the deletion of the genomic sequence between them. This deletion removes the entire histone complex. (Günesdogan et al., 2010)
Comments on Cytology

Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Molecular Data
Completely deleted	His1 (Günesdogan et al., 2010) His2A (Günesdogan et al., 2010) His2B (Günesdogan et al., 2010) His3 (Günesdogan et al., 2010) His4 (Günesdogan et al., 2010) HIS-C (Günesdogan et al., 2010)
Partially deleted	Lamp1 (Günesdogan et al., 2010)
Genes NOT Deleted / Disrupted
Complementation Data
Molecular Data
	nrv3 (Günesdogan et al., 2010)
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Homozygotes die during embryogenesis. The embryos complete the first 14 cycles of embryogenesis with no scorable defects and undergo mitosis 14 similarly to wild type. However, the embryos do not undergo mitosis 15. Increasing copy numbers of the histone gene repeat unit provided by transgenic constructs can rescue the Df(2L)His[C] phenotype: Df(2L)His[C] homozygotes that are also homozygous for M{1xHisGU.wt} develop a defective cuticle (Df(2L)His[C] homozygotes do not develop a cuticle). Df(2L)His[C] homozygotes that are also homozygous for M{3xHisGU.wt} develop a wild-type cuticle pattern but fail to hatch. Df(2L)His[C] homozygotes that carry four copies of M{3xHisGU.wt} (homozygous for two different insertions of M{3xHisGU.wt}) are rescued to become fertile adults with no visible morphological defects. (Günesdogan et al., 2010)
Stocks ( 0 )

Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Df(2L)His^C (Günesdogan et al., 2010)
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Günesdogan et al., 2010, EMBO Rep. 11(10): 772--776 A genetic system to assess in vivo the functions of histones and histone modifications in higher eukaryotes. [FBrf0211922]

Aberration Dmel\Df(2L)HisC

Aberration Dmel\Df(2L)His^C