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General Information
Symbol
Df(3L)Ssk
Species
D. melanogaster
Name
FlyBase ID
FBab0047333
Feature type
Sequence coordinates
3L:20,186,656..20,186,656 (Df(3L)Ssk:bk1)
3L:20,198,453..20,198,453 (Df(3L)Ssk:bk2)
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Class of aberration (relative to wild type)
Class of aberration (relative to progenitor)
Breakpoints
Causes alleles
Carries alleles
Formalized genetic data
Genetic mapping information
Comments

Df(3L)Ssk lacks the whole Ssk gene and the first and second exons included in the majority of CG42674 transcripts.

Comments on Cytology
Sequence Crossreferences
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
Partially deleted / disrupted
Molecular Data
Completely deleted
Genes NOT Deleted / Disrupted
Complementation Data
 
Molecular Data
 
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location
Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations

Gross midgut morphogenesis during embryonic development is not impaired in Df(3L)Ssk animals.

Only a small number of Df(3L)Ssk embryos hatch to first instar larvae, and those that do are sluggish in their movements and do not survive to the second instar stage.

The anterior midgut epithelial cells of late stage 17 Df(3L)Ssk embryos are more elongated in the apical-basal direction than those of wild type. While the wild type cells are cuboidal with a slightly rounded apical surface composed of microvilli, Df(3L)Ssk anterior midgut cells have apical membranes with microvilli often protruding into the lumen, though these cells do retain their apicobasal polarity.

In the midgut of late stage 17 Df(3L)Ssk embryos, parallel plasma membranes between cells are markedly reduced and intercellular spaces of irregular width are often observed. The intercellular space lacks electron-dense material and septa are observed at a much lower frequency than in wild type. The characteristic septa of smooth septate junctions is barely detectable.

The morphology of pleated septate junctions in the hindgut of late stage 17 Df(3L)Ssk embryos is normal, with parallel plasma membranes containing clear septa.

Stocks (0)
Notes on Origin
Discoverer
 
Balancer / Genotype Variants of the Aberration
 
Separable Components
 
Other Comments
 
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (4)