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General Information
Symbol
Df(3L)knittrigΔ1
Species
D. melanogaster
Name
FlyBase ID
FBab0047592
Feature type
Also Known As
knittrigΔ1
Computed Breakpoints include
Sequence coordinates
3L:8,768,907..8,768,907 (Df(3L)knittrigDelta1:bk1)
3L:8,825,477..8,825,477 (Df(3L)knittrigDelta1:bk2)
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Class of aberration (relative to wild type)
Class of aberration (relative to progenitor)
Breakpoints
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data
Genetic mapping information
Comments

Imprecise excision of P{lwB}AA142 resulting in complete removal of sequences encoding Fhos isoforms PA, PB, PD, PE, PF and PG and a cluster of small genes mostly encoding predicted chitin-binding proteins.

Comments on Cytology
Sequence Crossreferences
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Genes NOT Deleted / Disrupted
Complementation Data
 
Molecular Data
 
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Phenotypic Data
In combination with other aberrations

Df(3L)knittrigΔ1 embryos transheterozygous with Df(3L)knittrigΔ140, Df(3L)h-i22, Df(3L)Scf-R6, Df(3L)ED4421 or Df(3L)ED4413 show reduced formation of ganglionic tracheal branches with significant penetrance - the majority of embryos show disruption in at least one ganglionic branch. No abnormal phenotype is detected for midline glial cells.

Df(3L)knittrigΔ1 flies transheterozygous with Df(3L)knittrigΔ140, Df(3L)h-i22, Df(3L)Scf-R6, Df(3L)ED4421 or Df(3L)ED4413 show reduced viability and only rare escaper flies are found. Most mutants die during pupal stages or as pharate adults. Most escapers are unable to undergo complete wing inflation, causing wrinkled wings. Some escapers show partially inflated and abnormally opaque wings. Mutant pupal wings appar normal.

Inferred to overlap with: Df(3L)h-i22.

Inferred to overlap with: Df(3L)Scf-R6.

Inferred to overlap with: Df(3L)ED4413.

Inferred to overlap with: Df(3L)ED4421.

Inferred to overlap with: Df(3L)knittrigDelta140.

NOT in combination with other aberrations

Homozygotes show reduced viability and only rare escaper flies are found. Most mutants die during pupal stages or as pharate adults. Most escapers are unable to undergo complete wing inflation, causing wrinkled wings. Some escapers show partially inflated and abnormally opaque wings. Mutant pupal wings appar normal.

Macrophages isolated from Df(3L)knittrigΔ1 larvae show normal lamellapodia formation but display strong defects in cell flattening and spreading.

Following a laser-induced wound in the pupal wing, macrophages in Df(3L)knittrigΔ1 mutants are still able to respond and migrate to wound sites, but their speed and direction of migration are impaired.

Stocks (0)
Notes on Origin
Discoverer
 
Balancer / Genotype Variants of the Aberration
 
Separable Components
 
Other Comments
 
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Df(3L)knittrigΔ1
Name Synonyms
Secondary FlyBase IDs
    References (3)