Open Close
General Information
Symbol
Df(1)Δ3miR
Species
D. melanogaster
Name
FlyBase ID
FBab0047608
Feature type
Computed Breakpoints include
Sequence coordinates
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
Class of aberration (relative to wild type)
Class of aberration (relative to progenitor)
Breakpoints
Carries alleles
Formalized genetic data
Genetic mapping information
Comments

The miRNA cluster which encodes mir-12, mir-283 and mir-304 has been deleted and replaced by a loxP cassette containing a w+mW.hs marker. This cluster is present in an intron of Gmap, and the expression of Gmap is reduced compared to wild type in the deletion chromosome.

Comments on Cytology
Sequence Crossreferences
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
Partially deleted / disrupted
Molecular Data
Partially deleted
Genes NOT Deleted / Disrupted
Complementation Data
 
Molecular Data
 
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations

Df(1)Δ3miR mutants exhibit 88.3% lethality before the L1 stage. Most mutants die well before the end of embryogenesis. In Df(1)Δ3miR mutant dead embryos, nuclei are observed but cell membranes are lacking. Df(1)Δ3miR escaper embryos present wild type organization. No defects in egg chamber organisation are seen in adult escapers. No differences from wild type are observed in the wings, eyes, legs and abdomen. Rescue experiments demonstrate that the lethality is mainly due to the absence of the miRNA cluster, rather than an effect on Gmap.

Stocks (0)
Notes on Origin
Discoverer
 
Balancer / Genotype Variants of the Aberration
 
Separable Components
 
Other Comments
 
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Df(1)Δ3miR
Name Synonyms
Secondary FlyBase IDs
    References (2)