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General Information
Symbol
Dmel\αTub84B5
Species
D. melanogaster
Name
FlyBase ID
FBal0000017
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

C7088272T

Amino acid change:

P348S | alphaTub84B-PA

Reported amino acid change:

P348S

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: P348S.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Transheteroallelic combinations produce males that are sterile or weakly fertile.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference

alphaTub84B[+]/αTub84B5 is an enhancer of visible phenotype of Scer\GAL4GMR.PF/Scer\GAL4GMR.PF, bchsEP2299

Other
Phenotype Manifest In
Enhancer of
Statement
Reference

alphaTub84B[+]/αTub84B5 is an enhancer of eye phenotype of Scer\GAL4GMR.PF/Scer\GAL4GMR.PF, bchsEP2299

Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

Flies double heterozygous for αTub84B5 and TBCB1 are viable, but display strongly reduced fertility and follicle cell polarity defects.

Expression of αTub85EβTub85D.PH partially rescues the defective αTub84B function in spermatogenesis: most spermatids have complete axonemes.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer

K. Matthews.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
Alpha-Tubulin84B5
α-tubulin 84B5
α-tubulin84B5
Name Synonyms
Secondary FlyBase IDs
    References (6)