hypomorphic allele - genetic evidence
amorphic allele - genetic evidence
P348S | alphaTub84B-PA
Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.
Amino acid replacement: P348S.
lethal | recessive
male semi-sterile (with αTub84Bunspecified)
Transheteroallelic combinations produce males that are sterile or weakly fertile.
alphaTub84B[+]/αTub84B5 is an enhancer of visible phenotype of Scer\GAL4GMR.PF/Scer\GAL4GMR.PF, bchsEP2299
αTub84B5, TBCB[+]/TBCB1 has semi-fertile | recessive phenotype
αTub84B5, TBCB[+]/TBCB1 has abnormal cell polarity | recessive | adult stage phenotype
alphaTub84B[+]/αTub84B5 is an enhancer of eye phenotype of Scer\GAL4GMR.PF/Scer\GAL4GMR.PF, bchsEP2299
αTub84B5, TBCB[+]/TBCB1 has follicle cell phenotype
Flies double heterozygous for αTub84B5 and TBCB1 are viable, but display strongly reduced fertility and follicle cell polarity defects.
Expression of αTub85EβTub85D.PH partially rescues the defective αTub84B function in spermatogenesis: most spermatids have complete axonemes.