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General Information
Symbol
Dmel\βTub85D3
Species
D. melanogaster
Name
FlyBase ID
FBal0000025
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
B2t3
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

C9409979T

Reported nucleotide change:

C?T

Amino acid change:

S25L | betaTub85D-PA

Reported amino acid change:

S25L

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: S25L. Nucleotide substitution: TCG to TTG.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The testes of homozygous males are characterised by complete lack of microtubule-dependent function in the postmitotic germ cells. There is also no evidence of meiotic spindle activity, the spermatid nuclei remain 4N and the spermatid head remains unshaped. The spermatid fails to elongate.

Affects microtubule function during spermatogenesis.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

βTub85D3 has male sterile | dominant phenotype, enhanceable by wrl1

Suppressor of
Statement
Reference
Other
Statement
Reference
Phenotype Manifest In
Enhanced by
Statement
Reference

βTub85D3 has phenotype, enhanceable by haync2

Additional Comments
Genetic Interactions
Statement
Reference

βTub85D3 heterozygotes partially rescue the male sterile phenotype of males carrying βTub60D::βTub85Dstar; only a few motile sperm are present in the seminal vesicles.

Mutant males carrying one copy of αTub84B7.tHa and heterozygous for βTub85D3 display reduced fertility in mating tests: the aberrant protein from βTub85D3 retains a residual function.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
Comments
Comments

Class I allele.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (8)