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General Information
Symbol
Dmel\βTub85DDrv1
Species
D. melanogaster
Name
FlyBase ID
FBal0000034
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

T9409206A

Reported nucleotide change:

T?A

Amino acid change:

L263Q | betaTub85D-PA

Reported amino acid change:

L263Q

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Mutation that destabilises the βTub85DD protein.

Nucleotide substitution: T?A.

Amino acid replacement: L263Q.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The testes of homozygous males are characterised by complete lack of microtubule-dependent function in the postmitotic germ cells; no evidence of meiotic spindle activity; spermatid nuclei remain 4N and the spermatid head remains unshaped; spermatids fail to elongate.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

βTub85DDrv1 heterozygotes partially rescue the male sterile phenotype of βTub60D::βTub85Dstar; only a few motile sperm are present in the seminal vesicles.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
Comments
Comments

Class I allele.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
TB2D+R1
β2tD+R1
βTub85DDrv1
Name Synonyms
Secondary FlyBase IDs
    References (5)