Allele Dmel\abd-A^D24

General Information
Symbol	Dmel\abd-A^D24	Species	D. melanogaster
Name		FlyBase ID	FBal0000080
Feature type	allele	Associated gene	Dmel\abd-A
Also Known As	iab-2^D24, abdA^D24

Allele class	amorphic allele - genetic evidence, loss of function allele
Mutagen	ethyl methanesulfonate
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	amorphic allele - genetic evidence (Capovilla et al., 1994, Hopmann et al., 1995) loss of function allele (Busturia et al., 1989, Karch et al., 1990, Kurant et al., 1998)
Mutagen	ethyl methanesulfonate (Karch et al., 1985)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Point mutation. (Karch et al., 1985)
Cytology	Polytene chromosomes normal. Polytene chromosomes normal. (Karch et al., 1985)
Phenotypic Data
Phenotypic Class
	lethal \| homeotic \| recessive (Busturia et al., 1989) lethal \| recessive (Jijakli and Ghysen, 1992)
Phenotype Manifest In
	abdominal lateral pentascolopidial chordotonal organ lch5 (Inbal et al., 2004) embryonic/larval central nervous system (Jijakli and Ghysen, 1992) embryonic epidermis (with abd-A^JX2) (Hendrickson and Sakonju, 1995) lch5 ligament attachment cell (Inbal et al., 2004) lch5 neuron (Kurant et al., 1998) midgut constriction 2 (Mathies et al., 1994) midgut constriction 3 (Mathies et al., 1994) parasegment 7 (Busturia et al., 1989) parasegment 8 (Busturia et al., 1989) parasegment 9 (Busturia et al., 1989) parasegment 10 (Busturia et al., 1989) parasegment 11 (Busturia et al., 1989) parasegment 12 (Busturia et al., 1989) parasegment 13 (Busturia et al., 1989)
Detailed Description
	Statement Reference lch5 chordotonal organs are frequently mislocalised to the dorsal side of abd-A^D24 mutant embryos. These mislocalised chordotonal organs lack ligament attachment cells. (Inbal et al., 2004) The LCh5 neurons are abnormal in homozygous embryos, and are rarely found in a lateral or dorso-lateral position. The LCh5 neurons exhibit a DCh3-like morphology in abd-A^D24 hth^dtl-S142204 double mutant embryos and are positioned laterally in 17-19% of abdominal segments. (Kurant et al., 1998) Cuticle preparations of embryos heterozygous with abd-A^D24 show transformations of abdominal segments towards an A1 identity. (Hendrickson and Sakonju, 1995) Two posterior midgut constrictions fail to form. (Mathies et al., 1994) First instar larvae exhibit lateral dots (a paired structure found in A1 segment of wild type) in abdominal segment A2 to A5 and rarely in A6. (Jijakli and Ghysen, 1992) Hemizygous embryonic phenotype displays complete transformation of abdominal parasegments 7, 8 and 9 into parasegment 6 and partial transformation of abdominal parasegments 10 to 13 into parasegment 6 (FBrf0043314). (Busturia et al., 1989)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference Dp(3;2)D109; abd-A^D24, Abd-B^D18/Df(3R)Ubx-RS4-8 males are phenotypically indistinguishable from Abd-B^D18/Df(3R)Ubx-RS4-8 males in abdominal segmentation and show A5 and A6 identities. Dp(3;2)D109; Ubx¹, abd-A^D24, Abd-B^D18/Df(3R)Ubx-RS4-8 males show A5 and A6 identities while Dp(3;2)D109; Df(3R)RS1-98/Df(3R)Ubx-RS4-8 lack A5 and A6 identities. (Hopmann et al., 1995)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 2 )
Bloomington	1138 Dp(3;1)P68; abd-A^D24 Abd-B^D18/TM1 1108 Dp(3;1)P68; ss¹ Ubx¹ abd-A^D24 Abd-B^D18/In(3LR)Ubx^U, Sb^sbd-2 ss¹ Ubx^bx-34e Ubx^U
Notes on Origin
Discoverer	Duncan. I. Duncan.

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	abdA^D24 (Karch et al., 1990, Kannan et al., 2010) abd-A^D24 (Kuzin et al., 2011) abd-A^iab-D24 (Inbal et al., 2004) iab-2^D24 (Kurant et al., 1998, Capovilla et al., 1994, Karch et al., 1985) iab2^D24
Name Synonym
Secondary FlyBase IDs

References ( 17 )
Research paper	Kuzin et al., 2011, Mech. Dev. 128(3-4): 165--177 Functional analysis of conserved sequences within a temporally restricted neural precursor cell enhancer. [FBrf0213297] Kannan et al., 2010, Mech. Dev. 127(1-2): 137--145 Abdominal-A mediated repression of Cyclin E expression during cell-fate specification in the Drosophila central nervous system. [FBrf0209859] Inbal et al., 2004, Dev. Cell 7(2): 241--250 Recruitment of ectodermal attachment cells via an EGFR-dependent mechanism during the organogenesis of Drosophila proprioceptors. [FBrf0180120] Wiellette and McGinnis, 1999, Development 126(9): 1985--1995 Hox genes differentially regulate Serrate to generate segment-specific structures. [FBrf0108425] Kurant et al., 1998, Development 125(6): 1037--1048 dorsotonals/homothorax, the Drosophila homologue of meis1, interacts with extradenticle in patterning of the embryonic PNS. [FBrf0101934] Haerry and Gehring, 1997, Dev. Biol. 186(1): 1--15 A conserved cluster of homeodomain binding sites in the mouse Hoxa-4 intron functions in Drosophila embryos as an enhancer that is directly regulated by Ultrabithorax. [FBrf0093491] Cimbora and Sakonju, 1995, Dev. Biol. 169(2): 580--595 Drosophila midgut morphogenesis requires the function of the segmentation gene odd-paired. [FBrf0081623] Hendrickson and Sakonju, 1995, Genetics 139(2): 835--848 Cis and Trans interactions between the iab regulatory regions and abdominal-A and abdominal-B in Drosophila melanogaster. [FBrf0080088] Hopmann et al., 1995, Genetics 139(2): 815--833 Transvection in the iab-5,6,7 region of the bithorax complex of Drosophila: Homology Independent interactions in trans. [FBrf0080101] Capovilla et al., 1994, Cell 76(3): 461--475 Direct regulation of decapentaplegic by Ultrabithorax and its role in Drosophila midgut morphogenesis. [FBrf0068441] Mathies et al., 1994, Development 120(10): 2799--2809 Role of the teashirt gene in Drosophila midgut morphogenesis: secreted proteins mediate the action of homeotic genes. [FBrf0073854] Jijakli and Ghysen, 1992, Int. J. Dev. Biol. 36(1): 93--99 Segmental determination in Drosophila central nervous system: analysis of the abdominal-A region of the Bithorax complex. [FBrf0056377] Lloyd and Sakonju, 1991, Mech. Dev. 36: 87--102 Characterization of two Drosophila POU domain genes, related to oct-1 and oct-2, and the regulation of their expression patterns. [FBrf0054628] Karch et al., 1990, Genes Dev. 4(9): 1573--1587 abdA expression in Drosophila embryos. [FBrf0051832] Busturia et al., 1989, Development 107: 575--583 Genetic structure of the abd-A gene of Drosophila. [FBrf0049558] Karch et al., 1985, Cell 43: 81--96 The abdominal region of the Bithorax complex. [FBrf0042053]
Review	Duncan, 2002, A. Rev. Genet. 36: 521--556 Transvection effects in Drosophila. [FBrf0151731]

Allele Dmel\abd-AD24

Allele Dmel\abd-A^D24