FlyBase Allele Report: Dmel\abd-A[iab3-Uab4]

General Information

Symbol

Dmel\abd-A^iab3-Uab4

Species

D. melanogaster

Name

FlyBase ID

FBal0000097

Feature type

allele

Associated gene

Dmel\abd-A

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Karch et al., 1985)

Progenitor genotype

Caused by aberration

In(3LR)iab3⁴

Cytology

Description

Mutation maps outside the 5' end of the transcription unit.

(Macias et al., 1990)

Lesion mapped to: 58.5-61.5 kb.

(Karch et al., 1985)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable

(Jijakli and Ghysen, 1992)

visible | dominant | homeotic

(Karch et al., 1985)

visible | homeotic

(Busturia et al., 1989)

Phenotype Manifest In

adult abdominal segment 1

(Busturia et al., 1989)

adult abdominal segment 2

(Busturia et al., 1989)

adult abdominal segment 3

(Busturia et al., 1989, Karch et al., 1985)

adult abdominal segment 4

(Busturia et al., 1989, Karch et al., 1985)

adult abdominal segment 5

(Busturia et al., 1989, Karch et al., 1985)

adult abdominal segment 6

(Karch et al., 1985)

gonad | female

(Karch et al., 1985)

gonad | male

(Karch et al., 1985)

larval abdominal 3 neuromere (with abd-A^MX1)

(Prokop et al., 1998)

larval abdominal 3 neuromere (with Df(3R)Ubx109)

(Prokop et al., 1998)

larval abdominal 4 neuromere (with abd-A^MX1)

(Prokop et al., 1998)

larval abdominal 4 neuromere (with Df(3R)Ubx109)

(Prokop et al., 1998)

larval abdominal 5 neuromere (with abd-A^MX1)

(Prokop et al., 1998)

larval abdominal 5 neuromere (with Df(3R)Ubx109)

(Prokop et al., 1998)

larval abdominal 6 neuromere (with abd-A^MX1)

(Prokop et al., 1998)

larval abdominal 6 neuromere (with Df(3R)Ubx109)

(Prokop et al., 1998)

larval abdominal 7 neuromere (with abd-A^MX1)

(Prokop et al., 1998)

larval abdominal 7 neuromere (with Df(3R)Ubx109)

(Prokop et al., 1998)

parasegment 8

(Sanchez-Herrero, 1991)

parasegment 9

(Sanchez-Herrero, 1991)

parasegment 10

(Sanchez-Herrero, 1991)

parasegment 11

(Sanchez-Herrero, 1991)

parasegment 12

(Sanchez-Herrero, 1991)

Detailed Description

Statement

Reference

abd-A^iab3-Uab4/Df(3R)Ubx109 and abd-A^iab3-Uab4/abd-A^MX1 larvae have approximately 12 postembryonic neuroblasts in each of the abdominal neuromeres A3 to A7 (compared to 6 in wild-type). Each of these extra neuromeres produces a hundred or more progeny.

(Prokop et al., 1998)

Hemizygous embryos show transformed parasegments 8--12 to parasegment 7 (FBrf0042053).

(Sanchez-Herrero, 1991)

Hemizygotes show A2 transformed to A1 and of A3-A5 to A2.

(Busturia et al., 1989)

Adult abdominal segments 3-6 are transformed towards the second. The Wheeler's organ appears partially formed in segments 3-6. Individuals of both sexes lack gonads. In(3LR)iab3⁴ individuals have a dominant abd-A^iab3-Uab4 phenotype, first abdominal segment partially transformed to the second or third.

(Karch et al., 1985)

Causes A1 to transform toward A2.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Kyoto

107068

In(3LR)iab3⁴, abd-A^iab3-Uab4/Dp(3;3)81-83, Abd-B^Sab-1 Abd-B^Mcp-1

Notes on Origin

Discoverer

Lewis.

E. B. Lewis.

(Karch et al., 1985)

Comments

Reversion studies show that abd-A^iab3-Uab4 causes abnormal expression of abd-A domain functions in A1.

Ectopic expression of the protein during germ band elongation (FBrf0049558).

(Macias et al., 1990)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

Uab⁴

(Lewis, 1998, Duncan, 1982)

abd-A^iab3-Uab4

iab-3^Uab-4

(Jijakli and Ghysen, 1992)

iab3^Uab4

iab3^Uab

iab³Uab⁴

(Prokop et al., 1998)

Name Synonyms

Ultraabdominal

Secondary FlyBase IDs

References (12)

Report Sections

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