Allele Dmel\Abd-B^iab9-48

General Information
Symbol	Dmel\Abd-B^iab9-48	Species	D. melanogaster
Name		FlyBase ID	FBal0000137
Feature type	allele	Associated gene	Dmel\Abd-B
Also Known As	48, Abd-B^.48

Allele class	loss of function allele
Mutagen	X ray
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	loss of function allele (Celniker et al., 1990)
Mutagen	X ray (Kuhn et al., 1993)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Breakpoint maps to between coordinates +159 and +165kb. (Kuhn et al., 1993) Lesion maps to between coordinates 160kb and 165kb of Karch et al. (FBrf0042053). (Karch et al., 1990) Lesion mapped to: +163-166.5 kb. (Karch et al., 1985)
Caused by aberration	In(3R)Abd-B^iab9-48 (Kuhn et al., 1993, Kuhn et al., 1995)
Cytology
Phenotypic Data
Phenotypic Class
	visible \| homeotic \| somatic clone (Sanchez-Herrero and Crosby, 1988) visible \| recessive (Kuhn et al., 1993)
Phenotype Manifest In
	abdominal segment 4 \| ectopic \| somatic clone (Sanchez-Herrero and Crosby, 1988) abdominal segment 5 \| somatic clone (Sanchez-Herrero and Crosby, 1988) abdominal segment 6 \| somatic clone (Sanchez-Herrero and Crosby, 1988) abdominal segment 7 \| somatic clone (Sanchez-Herrero and Crosby, 1988) abdominal segment 8 \| somatic clone (Sanchez-Herrero and Crosby, 1988) denticle & embryonic abdominal segment 9 \| somatic clone (Sanchez-Herrero and Crosby, 1988) denticle \| somatic clone (Sanchez-Herrero and Crosby, 1988) embryonic/first instar larval cuticle (Kuhn et al., 1995) embryonic/larval posterior spiracle \| embryonic stage (Kuhn et al., 1995) embryonic abdominal segment 8 \| somatic clone (Sanchez-Herrero and Crosby, 1988) embryonic abdominal segment 9 \| somatic clone (Sanchez-Herrero and Crosby, 1988) genitalia (Kuhn et al., 1993) genitalia \| female \| somatic clone (Sanchez-Herrero and Crosby, 1988) parasegment 9 \| ectopic \| somatic clone (Sanchez-Herrero and Crosby, 1988) parasegment 10 \| somatic clone (Sanchez-Herrero and Crosby, 1988) parasegment 11 \| somatic clone (Sanchez-Herrero and Crosby, 1988) parasegment 12 \| somatic clone (Sanchez-Herrero and Crosby, 1988) parasegment 13 \| somatic clone (Sanchez-Herrero and Crosby, 1988) sclerite & abdominal segment 8 & embryo \| somatic clone (Sanchez-Herrero and Crosby, 1988) sclerite \| somatic clone (Sanchez-Herrero and Crosby, 1988)
Detailed Description
	Statement Reference Third instar larvae have a large naked cuticle region posterior to the 8th denticle band and a rather complete 9th denticle band. Embryos lack posterior spiracles. (Kuhn et al., 1995) Homozygous males and homozygous females have eight abdominal segments. Suppresses penetrance of head defect phenotype when in trans with Abd-B^iab9-tuh-3. Heterozygotes with Abd-B^iab9-tuh-3 exhibit genital defects with relatively high penetrance. Abd-B^iab9-tuh-3. Heterozygotes with Abd-B^iab9-tuh-3 exhibit genital defects with relatively high penetrance. (Kuhn et al., 1993) A5-A8 (including female genitalia) transformed to A4 in mosaics. Embryos have extra denticles in A9, and parasegments 10-13 are transformed to parasegment 9. (Sanchez-Herrero and Crosby, 1988)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	Abd-B³⁸⁰ (Sanchez-Herrero and Crosby, 1988) Abd-B^F (Sanchez-Herrero and Crosby, 1988) Abd-B^iab8-D6 (Sanchez-Herrero and Crosby, 1988) Abd-B^iab8-D14 (Sanchez-Herrero and Crosby, 1988) Abd-B^iab8-D15 (Sanchez-Herrero and Crosby, 1988) Abd-B^iab8-rv82 (Sanchez-Herrero and Crosby, 1988) Abd-B^iab8-rv89 (Sanchez-Herrero and Crosby, 1988) Abd-B^iab8-rv96 (Sanchez-Herrero and Crosby, 1988) Abd-B^iab8-rv100 (Sanchez-Herrero and Crosby, 1988) Abd-B^iab8-rv107 (Sanchez-Herrero and Crosby, 1988) Abd-B^iab8-rv111 (Sanchez-Herrero and Crosby, 1988) Abd-B^iab8-rv114 (Sanchez-Herrero and Crosby, 1988) Abd-B^iab8-rv175 (Sanchez-Herrero and Crosby, 1988) Abd-B^iab8-rv185 (Sanchez-Herrero and Crosby, 1988) Abd-B^iab9-Tab (Sanchez-Herrero and Crosby, 1988) Abd-B^iab9-tuh-3 (Sanchez-Herrero and Crosby, 1988) Abd-B^iab9-x23-1 (Sanchez-Herrero and Crosby, 1988) Abd-B^M2 (Sanchez-Herrero and Crosby, 1988) Abd-B^M3 (Sanchez-Herrero and Crosby, 1988) Abd-B^M4 (Sanchez-Herrero and Crosby, 1988) Abd-B^M5 (Sanchez-Herrero and Crosby, 1988) Abd-B^M6 (Sanchez-Herrero and Crosby, 1988) Abd-B^M7 (Sanchez-Herrero and Crosby, 1988) Abd-B^M9 (Sanchez-Herrero and Crosby, 1988) Abd-B^R (Sanchez-Herrero and Crosby, 1988) Abd-B^S1 (Sanchez-Herrero and Crosby, 1988) Abd-B^S2 (Sanchez-Herrero and Crosby, 1988) Abd-B^S5 (Sanchez-Herrero and Crosby, 1988) Abd-B^S8 (Sanchez-Herrero and Crosby, 1988) Abd-B^S9 (Sanchez-Herrero and Crosby, 1988) Abd-B^Uab-1 (Sanchez-Herrero and Crosby, 1988)
Comments	Fails to complement all mutations in the Abd-B domain. Interactions with Abd-B domain mutations may be variable & weak. (Sanchez-Herrero and Crosby, 1988)
Stocks ( 0 )

Notes on Origin
Discoverer	R.H. Baker.

Comments
	Abd-B m^-(+)r^- mutation. (Kuhn et al., 1995) Both m and r function affected to some degree. (Kuhn et al., 1993) Less extreme than Abd-B^iab8-D16 or Abd-B^iab8-D3. See also Celinker et al. (FBrf0049804). (Karch et al., 1990)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	48 (Kuhn et al., 1995, Kuhn et al., 1993) Abd-B⁴⁸ (Estrada et al., 2002) Abd-B^.48 (Kuhn et al., 1993, Karch et al., 1990) Abd-B^iab9-48 iab-7⁴⁸ (Sanchez-Herrero and Crosby, 1988) iab9⁴⁸
Name Synonym
Secondary FlyBase IDs
	FBal0028654
References ( 9 )
Research paper	Estrada et al., 2002, Development 129(22): 5195--5204 Genetic and molecular characterization of a novel iab-8 regulatory domain in the Abdominal-B gene of Drosophila melanogaster. [FBrf0151935] Kuhn et al., 1995, Mech. Dev. 53(1): 3--13 Analysis of the genes involved in organizing the tail segments of the Drosophila melanogaster embryo. [FBrf0084100] Kuhn et al., 1993, Genetics 133(3): 593--604 Tumorous-head (tuh-1; tuh-3) modulates Abd-B Bithorax-complex functions in Drosophila melanogaster. [FBrf0058571] Kuhn et al., 1992, Development 116(1): 11--20 Development of the Drosophila melanogaster caudal segments involves suppression of the ventral regions of A8, A9 and A10. [FBrf0055839] Celniker et al., 1990, EMBO J. 9(13): 4277--4286 The molecular genetics of the Bithorax complex of Drosophila: cis-regulation in the Abdominal-B domain. [FBrf0051665] Karch et al., 1990, Genes Dev. 4(9): 1573--1587 abdA expression in Drosophila embryos. [FBrf0051832] Celniker et al., 1989, Genes Dev. 3: 1424--1436 The molecular genetics of the Bithorax complex of Drosophila: characterization of the products of the Abdominal-B domain. [FBrf0049804] Sanchez-Herrero and Crosby, 1988, EMBO J. 7(7): 2163--2173 The Abdominal-B gene of Drosophila melanogaster: overlapping transcripts exhibit two different spatial distributions. [FBrf0047933] Karch et al., 1985, Cell 43: 81--96 The abdominal region of the Bithorax complex. [FBrf0042053]

Allele Dmel\Abd-Biab9-48

Allele Dmel\Abd-B^iab9-48