Allele Dmel\Abd-B^Mcp-1

General Information
Symbol	Dmel\Abd-B^Mcp-1	Species	D. melanogaster
Name		FlyBase ID	FBal0000145
Feature type	allele	Associated gene	Dmel\Abd-B
Also Known As	Mcp¹, Mcp, Abd-B^Mcp

Allele class	gain of function allele
Mutagen	spontaneous
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	gain of function allele (Karch et al., 1994, Jeong et al., 2006)
Mutagen	spontaneous (Karch et al., 1985)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name X78982

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference The deletion uncovers the nuclease hypersensitive region of the Mcp, continuing distally towards the iab-5 region. (Muller et al., 1999) 3.5kb deletion in the cis regulatory region, removing a silencer element MCP725. (Busturia et al., 1997) Deletion of a 3.6kb DNA segment from the region in between iab-4 and iab-5 cis-regulatory domains (from map position +94 to +97.6kb in the bithorax complex). (Karch et al., 1994) Alteration at coordinate +94-97.6kb, proximal to the Abd-B transcript. (Kuhn et al., 1993) 94-97.6 kb deleted. (Karch et al., 1985)
Cytology	Polytene chromosomes normal. Polytene chromosomes normal. (Karch et al., 1985) Polytene chromosomes normal. (Kuhn et al., 1993)
Phenotypic Data
Phenotypic Class
	body color defective \| male \| recessive (Kopp et al., 2000) visible \| dominant (Karch et al., 1994) visible \| male \| recessive (Kopp et al., 2000)
Phenotype Manifest In
	abdominal segment 4 (Bejarano and Busturia, 2004, Karch et al., 1994) abdominal segment 5 \| ectopic (Bejarano and Busturia, 2004) adult cuticle & abdominal segment 3 \| male (Kopp et al., 2000) adult cuticle & abdominal segment 4 \| male (Kopp et al., 2000)
Detailed Description
	Statement Reference heterozygous mutant adults have a pigments abdominal segment 4, showing a transformation of the a4 to a5. This is seen in 100% of mutants, with constant and high expressivity. (Bejarano and Busturia, 2004) Heterozygous males show a decrease in the total amount of both monoene and 7,11-diene cuticular hydrocarbons compared to wild-type males. Heterozygous females show a significant increase in the level of monoene cuticular hydrocarbons and a significant decrease in the level of 7,11-diene cuticular hydrocarbons compared to wild-type females. (Wicker-Thomas and Jallon, 2001) In males homozygous for Abd-B^Mcp-1,Abd-B^Sab-1, male specific pigmentation is expanded into A3 and A4. (Kopp et al., 2000) A4 is transformed to A5 identity and is a darkly pigmented. (Karch et al., 1994)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement Reference Abd-B^Mcp-1/Abd-B^Mcp-1 is a suppressor \| partially of visible \| recessive phenotype of brk^Mcp (Kyrchanova and Georgiev, 2010, Kyrchanova and Georgiev, 2010)
Phenotype Manifest In
Enhanced by
Statement Reference Abd-B^Mcp-1 has phenotype, enhanceable by Pcl¹ (Duncan, 1982)
Suppressed by
Statement Reference Abd-B^Mcp-1 has abdominal segment 4 phenotype, suppressible \| partially by Trl^R85 (Bejarano and Busturia, 2004) Abd-B^Mcp-1 has abdominal segment 5 \| ectopic phenotype, suppressible \| partially by Trl^R85 (Bejarano and Busturia, 2004)
Suppressor of
Statement Reference Abd-B^Mcp-1/Abd-B^Mcp-1 is a suppressor \| partially of wing phenotype of brk^Mcp (Kyrchanova and Georgiev, 2010, Kyrchanova and Georgiev, 2010)
Other
Statement Reference Abd-B^Mcp-1, ph-d¹ has abdominal segment 3 phenotype (Dura et al., 1985) Abd-B^Mcp-1, ph-d² has abdominal segment 3 phenotype (Dura et al., 1985)
Additional Comments
Genetic Interactions
Statement Reference The penetrance of the wing defect phenotype caused by brk[Mcp] is decreased to 7.7% if the animals are also homozygous for Abd-B[Mcp-1]. (Kyrchanova and Georgiev, 2010) 96% of Abd-B^Mcp-1, Trl^R85 double heterozygotes have a partially de-pigmented abdominal segment 4. (Bejarano and Busturia, 2004) The third abdominal segment is transformed towards segment five or six in males also carrying ph-d¹ or ph-d². (Dura et al., 1985)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 5 )
Bloomington	3440 Abd-B^Mcp-1/TM1 3497 Abd-B^Sab-1 Abd-B^Mcp-1 24618 w^*; P{neoFRT}82B Abd-B^Mcp-1 Sce¹/TM6C, Sb¹ Tb¹
Kyoto	109082 Abd-B^Mcp-1/ TM6B, Tb¹ 107068 In(3LR)iab3⁴, abd-A^iab3-Uab4/Dp(3;3)81-83, Abd-B^Sab-1 Abd-B^Mcp-1
Notes on Origin
Discoverer	Crosby. M. Crosby.

Comments
	DNase hypersensitivity assays reveal the deletion contains one very prominent nuclease sensitive region as well as several minor hypersensitive sites. Mcp appears to be associated with an unusual chromatin structure. (Karch et al., 1994) The phenotype of Abd-B^Mcp-1/Abd-B^Mcp-1 closely resembles that of Abd-B^Cst/+. (Crosby et al., 1993) m^- r⁺ mutant, with defect in spatial regulation of Abd-B function. No effect on penetrance of head defect phenotype when in trans with Abd-B^iab9-tuh-3. (Kuhn et al., 1993)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	Abd-B^Mcp-1 Abd-B^Mcp (Kopp et al., 2000, Jeong et al., 2006) Mcp (Drewell et al., 2002, Duncan and Montgomery, 2002, Lewis, 1998, Crosby et al., 1993, Kuhn et al., 1993, Sanchez-Herrero, 1991, Duncan, 1986, Dura et al., 1985, Duncan, 1982) Mcp1 (Wicker-Thomas and Jallon, 2001) Mcp¹ (Bejarano and Busturia, 2004, Duncan, 2002, Muller et al., 1999, Busturia et al., 1997, Hopmann et al., 1995, Karch et al., 1994, Karch et al., 1985, Bantignies et al., 2011, Kyrchanova and Georgiev, 2010, Kyrchanova and Georgiev, 2010)
Name Synonym
Secondary FlyBase IDs

References ( 22 )

Generate a list of	All references relating to this allele ( 22 )

List References by type	Research paper ( 19 ) Review ( 2 ) Biography ( 1 )
Recent research papers ( 1 )
	Bantignies et al., 2011, Cell 144(2): 214--226 Polycomb-Dependent Regulatory Contacts between Distant Hox Loci in Drosophila. [FBrf0212775] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...

Allele Dmel\Abd-BMcp-1

Allele Dmel\Abd-B^Mcp-1