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General Information
Symbol
Dmel\ac3
Species
D. melanogaster
Name
FlyBase ID
FBal0000162
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Mutagen
Nature of the Allele
Mutagen
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Left breakpoint of In(1)ac3 at DNA coordinate +59 near the transcription start site of the ac.

Lesion maps to: 59.6 to 58.8 kb.

Caused by aberration
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

In ac3 flies, the following thoracic macrochaetae are missing: the posterior dorsocentral, the anterior dorsocentral and the posterior supra-alar. These flies also show a loss of microchaetae on the thorax posteriorly, laterally and centrally.

Homozygotes lack most microchaetae and some macrochaetae on the notum and legs.

Sensory mother cells of bristles pSA, aDC and pDC are absent in the wing disc, but mitotically quiescent centers from which they emerge were present for aDC and pDC and showed no difference from wild type.

No detectable ac protein accumulation. Removes the sc expression from the cells from which the ac-dependent pSA and DC bristles arise.

The total number of bristles on the basitarsi of the second legs is reduced. The number of bractless bristles on the basitarsi remains normal. Significantly more bristles are missing from the anterior side of the basitarsus than from the posterior side. One or the other of the distal sensilla is sometimes missing.

Posterior and usually anterior dorsocentrals lacking; other bristles wild type. Hairs removed from areas across rear and front edges of thorax, through mid-dorsal area and between ocelli.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Statement
Reference

ac3 has macrochaeta & leg phenotype, enhanceable by klu212lR63

ac3 has microchaeta & leg phenotype, enhanceable by klu212lR63

ac3 has macrochaeta & leg phenotype, enhanceable by kluP212

ac3 has microchaeta & leg phenotype, enhanceable by kluP212

ac3 has phenotype, enhanceable by emc[+]/emcD

Suppressed by
Statement
Reference

ac3 has phenotype, suppressible | partially by su(sc)ru1

ac3 has phenotype, suppressible | partially by emc1/emc11

NOT suppressed by
Statement
Reference

ac3 has phenotype, non-suppressible by su(Hw)2

Suppressor of
Statement
Reference

ac3 is a suppressor of phenotype of h1

Additional Comments
Genetic Interactions
Statement
Reference

The ac3 phenotype is strongly enhanced if the flies are also homozygous for klu212lR63, and slightly enhanced if the flies are also homozygous for kluP212.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer

Dubinin, 1929.

Comments
Comments

Transcript levels substantially reduced in both embryos and pupae; the l(1)sc transcript but not the sc transcript also reduced.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
ac2
sc10
sc11
Name Synonyms
Secondary FlyBase IDs
    References (23)