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General Information
Symbol
Dmel\acHw-1
Species
D. melanogaster
Name
FlyBase ID
FBal0000167
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Hw1, Hw
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

gypsy insertion within the ac coding sequences, resulting in a protein truncated 77 amino acids at the C terminus.

gypsy insertion in the ac region of the achaete-scute complex.

gypsy insert into ac coding region (also a 2.6kb jockey insert into y coding region).

Insertion components
gypsy{}acHw-1
Caused by aberration
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Mutant adults have ectopic macrochaetae on the notum, with the sites of the ectopic bristles clustering at sites devoid of sr expression.

acHw-1 mutant flies exhibit an occasional extra macrochaetae on the notum.

acHw-1/+ animals exhibit about 23 extra bristles per wing.

The number of olfactory sensilla on the surface of the third antennal segment is normal. Large bristles resembling macrochaetae are seen on the surface of the third antennal segment.

mod(mdg4)ul causes a partial suppression of the acHw-1 mutant phenotype. Strong su(Hw) mutations have a dominant suppressing effect on acHw-1 in combination with mod(mdg4)ul, weak su(Hw) mutations acquire properties of strong su(Hw) mutations when in combination with mod(mdg4)ul.

Glial cell along the anterior margin of the wing are normal, and additional glial cells are present where ectopic nerves develop. The ectopic nerves and glia develop later than the endogenous nerves and glia.

The total number of bristles on the basitarsi of the second legs is increased.

Double mutant acHw-1,h or acHw-1,emc flies augment the derepression of the ac-sc complex. acHw-1 and h, and acHw-1 and emc interact synergistically.

No significant effect of maternal da genotype on Hairy wing phenotypic expression is seen in triploid intersexes. SxlM1 reduces Hairy wing phenotypic expression in triploid intersexes.

Males and heterozygous females have extra bristles on the head (especially occipitals), the notum and the mesopleurae; also extra bristles, including sensory ones and campaniform sensilla (FBrf0037150), along longitudinal veins and in membrane of wing. Homozygous females more extreme; 110 extra chaetae on wing vs. 49.5 for acHw-1/+; 11 on scutellum and postnotum vs. 0.7 in acHw-1/+ (FBrf0023144). Number of extra bristles inversely correlated with temperature (FBrf0021579). acHw-1/acHw-1 females exhibit 40-80% wild-type viability and are agametic steriles; clones of homozygous germinal cells in acHw-1/+ females capable of producing progeny (FBrf0039441); however, Garcia-Alonso and Garcia-Bellido (FBrf0045360) claim that their strain is no longer homozygous female-sterile. Viability and fertility of acHw-1/Y males and acHw-1/+ females good. RK1 as male or heterozygous female.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

acHw-1 has visible phenotype, enhanceable by sr1

Other
Statement
Reference
Phenotype Manifest In
Enhanced by
Statement
Reference

acHw-1 has mesothoracic tergum & macrochaeta | ectopic phenotype, enhanceable by sr1

acHw-1 has wing margin bristle | ectopic phenotype, enhanceable by ttk[+]/ttk00219

acHw-1 has wing margin bristle | ectopic phenotype, enhanceable by ttk[+]/ttkrM730

Suppressed by
Statement
Reference

acHw-1 has macrochaeta | ectopic phenotype, suppressible by hhs.P1

acHw-1 has phenotype, suppressible by su(Hw)2

Enhancer of
Statement
Reference
Other
Additional Comments
Genetic Interactions
Statement
Reference

acHw-1 ; sr1 double mutant flies have a broader distribution of ectopic bristles over the notum than in flies mutant for acHw-1 alone. This effect is synergistic; the double mutant displays more bristles than the sum of the two single mutants.

acHw-1 mutant; sensScer\UAS.cNa; Scer\GAL4sca-537.4 flies have many more extra macrochaetae than the sum of the two genotypes alone.

The addition of ttkrM730/+ to acHw-1/+ animals leads to an 1.4 enhancement of the ectopic wing margin bristle phenotype. The addition of ttk00219/+ to acHw-1/+ animals leads to an 1.4 enhancement of the ectopic wing margin bristle phenotype. The addition of Df(3R)awd-KRB/+ to acHw-1/+ animals leads to an 1.4 enhancement of the ectopic wing margin bristle phenotype.

hunspecified pydunspecified acHw-1 triple mutants show synergistic increases in the number of bristles on the basitarsi of the second legs.

Ectopic bristle formation can be rescued by the presence of the hhs.P1 construct.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (19)
Notes on Origin
Discoverer

Bridges, 12th March 1923.

Arose on: yunspecified.

Comments
Comments

"Phenotypic class: female sterile | recessive" was stated as tentative. Many rearrangements with breakpoints in the distal portion of the achaeae-scute complex have a weak acHw-1 effect, especially as indicated by microchaetae on the mesopleurae; duplications for rearranged scute loci have enhanced effects.

acHw-1/acHw-1 and +/- are autonomous in somatic clones until 8 hr before puparium formation; altering cellular genotype after that time is without effect owing to perdurance.

Classifiable in a single dose in triploids.

Duplication of ac+ without phenotypic effects except that they suppress h1.

X-ray-induced full and partial revertants are frequently mutant for ac.

The status of this duplication is unclear. FBrf0004676 claimed it to be a tandem duplication for 1B1--1B2, but molecular analysis by Campuzano et al. (FBrf0043905) did not find any evidence for a duplication.

The distribution of expressing cells in the wing disk is much less localized than in wild type. Developmental Northern blots show peak accumulations in early embryos and early pupae.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
References (30)