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General Information
Symbol
Dmel\acHw-49c
Species
D. melanogaster
Name
FlyBase ID
FBal0000172
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Hw49c
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

One breakpoint between 14.8 kb and 13.5 kb in the walk of Campuzano et al. (FBrf0042024) and the other between 111 kb and 122 kb in the walk of Chao and Guild.

Caused by aberration
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

acHw-49c/+ animals exhibit about 60 extra bristles per wing.

acHw-49c animals have a higher density of notal microchaetae, however these bristles still approximately align into rows as seen in wild-type.

Ectopic neural precursors form along the longitudinal vein primordia.

Multiple bristles develop instead of a single anterior sternopleural bristle in acHw-49c flies. In acHw-49c; kluP212 double mutants, no bristles develop in the anterior sternopleural position.

Grooming behavior normal.

Two rows of ectopic sensory organ mother cells (SMCs) are seen on the presumptive posterior wing margin in acHw-49c wing imaginal discs. A few extra SMCs also emerge in the dorsocentral notum region during the third larval instar period.

Ectopic sense organs appear on the notum and wing.

The total number of bristles on the basitarsi of the second legs is increased. An enlarged bracted bristle is seen near position 5d1 in 22% of cases.

Often lack one or more ocellar or postvertical macrochaetae.

Width of mesonotum in region between dorsocentral bristles increased leading to increased numbers of acrostichal rows as well as extraneous extra microchaetae. Low degree of nonautonomy reported at junction between acHw-49c/acHw-49c and +/+ twin spots.

Homozygous female has doubling and tripling of many bristles, three or four extra dorsocentral bristles per side, extra wing veins, gap in posterior crossvein and extra hairs on vein L2 and in wing cells. Heterozygous female has normal bristles, extra hairs on L2 and L3 and in wing cells and often an extra free vein from posterior crossvein; also extra acrostichal rows. acHw-49c male much like homozygous female but bristle duplication less extreme. RK1. Not suppressed by su(Hw).

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Statement
Reference
Suppressed by
Statement
Reference
Other
Statement
Reference

emc11/Df(3L)emc-E12, acHw-49c has dorsal mesothoracic disc & sensory mother cell | ectopic phenotype

acHw-49c, emc11 has dorsal mesothoracic disc & sensory mother cell | ectopic phenotype

Oceunspecified, acHw-49c has macrochaeta & head phenotype

Oceunspecified, acHw-49c has macrochaeta & thorax phenotype

Additional Comments
Genetic Interactions
Statement
Reference

The addition of ttkrM730/+ to acHw-49c/+ animals leads to an 1.35 enhancement of the ectopic wing margin bristle phenotype. The addition of ttk00219/+ to acHw-49c/+ animals leads to an 1.2 enhancement of the ectopic wing margin bristle phenotype. The addition of Df(3R)awd-KRB/+ to acHw-49c/+ animals leads to an 1.5 enhancement of the ectopic wing margin bristle phenotype. The addition of ttk69.hs/+ to acHw-49c/+ animals leads slight suppression of the ectopic wing margin bristle phenotype (80% of the bristles seen in ttk69.hs/+ alone are seen in double mutants..

Bristles of variable size are formed in the otherwise naked lateral region of the notum of ara1 caup1/Df(3L)iro-2 flies that are also carrying acHw-49c, at a position corresponding to that of the posterior supraalar bristle. This bristle has a contralateral axon branch in about 70% of cases.

acHw-49c/+ ; emc11/Df(3L)emc-E12 wing discs have many ectopic SMCs, mostly in the presumptive notum and dorsal wing blade and base.

Double mutants with su(sc)1 are sterile and have crumpled wings.

The extra chaetae found over the wing veins in heterozygous acHw-49c/+ females are removed or reduced in number from the dorsal veins LIII and LV, but not from the LII and LIV ventral veins, by homozygous Egfrf37 clones in these regions.

hunspecified pydunspecified acHw-49c triple mutants show synergistic increases in the number of bristles on the basitarsi of the second legs.

Acts synergistically with Oce in removing head bristles but cancel each other's effects on thorax in acHw-49c/Oceunspecified females.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer

King, 21st March 1949.

Induced with: sc49c.

Comments
Comments

More extreme than acHw-1.

Double mutant acHw-49c, h1 or acHw-49c, emcunspecified flies augments the derepression of the achaete-scute complex.

Revertants of acHw-49c lose their dominant phenotypes; however they remain sc and may exhibit a weak ac phenotype or be lethal in combination with Df(1)sc19.

ac, sc and l(1)sc transcripts considerably more abundant than in wild type; also more generally expressed in wing discs than normal.

The expression of l(1)sc protein is reduced in mutant embryos.

Overexpression of the ac and sc proteins. The global pattern of h is unchanged but the level of expression is increased.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
References (26)