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General Information
Symbol
Dmel\Ace1
Species
D. melanogaster
Name
FlyBase ID
FBal0000182
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Acel26, l(3)26
Key Links
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Linked to:
HindIII-HindIII restriction fragment
Comment:

5kb of unknown DNA inserted within a HindIII fragment within the fifth intron; position of restriction fragment on reference sequence inferred by FlyBase curator

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology

Polytene chromosomes normal.

Nature of the lesion
Statement
Reference
Carried on aberration
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Lethal phase is late embryonic/early larval.

Lethality at end of embryonic stage. AChE-minus tissues survive in mosaics unless enzyme absent from posterior midbrain; surviving mosaics have defective visual physiology, optomotor behavior, or courtship depending on location of mutant clone. Such clones associated with defective morphology of neuropil of various ganglia in central nervous system.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by
Comments

Acelm38/Ace1 flies rescued by Ace+mFa occasionally show a bang-sensitive phenotype; flies subjected to mechanical shock sometimes produce a burst of uncoordinated motor activity followed by paralysis, from which they recover in approximately 30 seconds. Ace1/Acelm38 flies carrying two copies of AceTM.T:Hsim\gC are viable, although adults are often bang-sensitive.

Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer

Schalet, Kernaghan and Chovnick, 1964.

Induced with: ry26.

FlyBase curator comment: FBrf0050439 states that Ace1 is caused by the insertion of unknown DNA into the fifth intron at coordinate +30, however, FBrf0046381 shows that this insertion of DNA is separable from the Ace1 mutation by recombination.

The Ace1 chromosome contains an insertion of approximately 5kb that is not present in Canton-S or Oregon-R flies. The parental chromosome for Ace1 was never isolated and recombination analysis shows that the 5kb insertion is separable from the Ace1 mutation by recombination.

Comments
Comments

Greatly reduced levels of acetylcholinesterase.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (7)
References (14)